Navigation Links
Study illuminates how the plague bacteria causes disease

ing cell shape, Stebbins said.

Mutations that prevented the bacterial proteins' interaction with the host protein significantly impaired YpkA's ability to disrupt the cytoskeleton. Moreover, a mutant strain of Y. pseudotuberculosis that lacked the GDI activity caused significantly fewer problems for infected mice compared to normal bacteria.

"Earlier studies that focused only on the protein's kinase activity had missed half the picture," Stebbins said. "The GDI domain seems to have an even bigger effect on host cells in culture, and a significant impact on virulence."

The results also add to broader themes in the evolution of bacterial diseases, the researchers added.

"It is becoming increasingly clear that a common strategy used by bacterial pathogens to manipulate host cell biology is the mimicry of their own biochemical processes," Stebbins said.


'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:12/1/2008)... , , PROVIDENCE, R.I. [Brown University] Gray mo...wn by its scientific name Botrytis cinerea , is a...tal plant species, including staples such as tomat...ettuce and endive, peas, peppers, and potatoes. Gr...easing a toxin that poisons the host plants, cells...
(Date:12/1/2008)... , CHICAGO The December issue of the Journal of...rch studies focusing on the everyday eating habits...continue to be a popular meal choice and methods f... Studies published in the December 2008 Journal o...hy Eat at Fast-Food Restaurants: Reported Reasons ...
(Date:12/1/2008)... , Leuven (Belgium), Stockholm (Sweden) Permissi...tolerability trial on patients for a remedy for AL...ve disorder that strikes 5 persons in every 100,00...the most active period of their lives − with...n have previously shown the possibilities for the ...
(Date:12/1/2008)... , A stunning discovery based on epigenetics (the... reveals that consuming cholinea nutrient found in...antly affect breast cancer outcomes for a mother,s...t Boston University is the first to link choline c...lso is the first to identify possible choline-rela...
Breaking Biology News(10 mins):Brown chemist finds gray mold's killer gene 2News from the December 2008 Journal of the American Dietetic Association 2First trial in patients with a potential treatment of the incurable ALS muscle disease 2First trial in patients with a potential treatment of the incurable ALS muscle disease 3Eating eggs when pregnant affects breast cancer in offspring 2Depression Obesity Coexist in Many Middle Aged Women 9511 1Depression Obesity Coexist in Many Middle Aged Women 9511 2Heavy metal slips down UK air quality charts 9509 1Heavy metal slips down UK air quality charts 9509 2LifeVantage Corporation Appoints Industry Veteran David Brown as President 26 CEO 9508 1LifeVantage Corporation Appoints Industry Veteran David Brown as President 26 CEO 9508 2LifeVantage Corporation Appoints Industry Veteran David Brown as President 26 CEO 9508 3LifeVantage Corporation Appoints Industry Veteran David Brown as President 26 CEO 9508 4Natural Harmony Foods Works to Reduce Childhood Obesity 9506 1Natural Harmony Foods Works to Reduce Childhood Obesity 9506 2Natural Harmony Foods Works to Reduce Childhood Obesity 9506 3
...ery much greater rate of chromosomal abnormalities...ntist told the 22nd annual conference of the Europ...n Prague, Czech Republic on Wednesday 21 June 2006...of Obstetrics and Gynaecology, Chulalongkorn Unive... to be aware of this problem and monitor carefully...
...f time perception in the animal kingdom, researche...bumble bee, can estimate the duration of time inte... rhythms of behavior, the more sophisticated abili...als had previously been known only in humans and o... Michael Boisvert and David Sherry of the Universi...
...f regarding the cultural spread of tool use among ...n the Ebo forest, Cameroon, use stone hammers to c...-rich seeds. The findings are significant because ...ly in a distant chimpanzee population in extreme w...geographical boundaries that prevented cultural sp...
...lict and natural disaster, many people in countrie...of the same nutrition problems as those in crisis....Gross, PhD, UNICEF,s chief of nutrition, and Patri...edman School of Nutrition Science and Policy at Tu...ger, children and wasting, a condition that repres...
Other Biology News:Chromosomal abnormalities in sperm higher after vasectomy reversal 2Use of stone hammers sheds light on geographic patterns of chimpanzee tool use 2Five surprising facts about starvation that could change the international agenda 2Five surprising facts about starvation that could change the international agenda 3
(Date:12/1/2008)...N -- Plastics are everywhere in our modern world, ...s tough and durable, but lightweight and easily wo...r - the ability to bend rather than break when put..., This property, described as "plastic flow", allo...rather than breaking apart, says University of Wis...
(Date:12/1/2008)... The U.S. Pharmacopeial (USP) Co...n joined the organization as vice president of ext...r 1, 2008. , Rockville, M...eial (USP) Convention is pleased to announce that...esident of external affairs and strategic integrat...
(Date:12/1/2008)...for Siemens Biograph mCT supports need for new way...AGO, Dec. 1 First introduced at t...in October , Siemens Biograph mCT hits the ground...the current economical situation demands maximum u...Biograph mCT reaches the United States as a pion...
(Date:12/1/2008)...LE, Md., Dec. 1 Novavax,...company, announced today that Dr.,Rahul Singhvi, ...senting at,the Piper Jaffray 20th Annual Healthca...2008 in New York. Dr. Singhvi will provide an over...lopment progress. A link to the live,presentation...
Breaking Biology Technology:Fast molecular rearrangements hold key to plastic's toughness 2Fast molecular rearrangements hold key to plastic's toughness 3USP Names Matthew Heyman Vice President of External Affairs and Strategic Integration 2USP Names Matthew Heyman Vice President of External Affairs and Strategic Integration 3Imaging in Living Color with Siemens Molecular CT 2Imaging in Living Color with Siemens Molecular CT 3Imaging in Living Color with Siemens Molecular CT 4
... , , , , , , Now that w... the functions,of proteomes, the sum of all,pr...,Assembling the protein puzzle,presents an even...e,genome. The reason for this is the complexity ...tivity of these proteins,to environmental condit...
... , , , , , , Protocol ... , , , Below, a standard protocol f...,FuGENE 6 is presented that has been specially des...n. , , , 1. Prepare cells the day ...sure the cells are growing well and are in log pha...
... , , , , , , Troublesh...than 5 - ,10 % Cell Death) , , , F...ually nontoxic to most cell ,types. If you obser...sfection ,experiments, or if selection of perman...ow for possible causes. , , , ,...
..., , Serial Analysis of Gene Expression (S... profiling technology. Agencourt offers , a...g of both SAGE and LongSAGE , libraries to ...s. Agencourt,s , SAGE sequencing service pr... turnaround , , Long Phred20 read ...
Other Biology Technology:Tools for Proteomic Science II 2Tools for Proteomic Science II 3Tools for Proteomic Science II 4Uses and Applications of FuGENE 6 Transfection Reagent 2Uses and Applications of FuGENE 6 Transfection Reagent 3Uses and Applications of FuGENE 6 Transfection Reagent 4Uses and Applications of FuGENE 6 Transfection Reagent 2Uses and Applications of FuGENE 6 Transfection Reagent 3SAGE & LONGSAGE SEQUENCING 2
Although each Beacon 2000 System includes one preinstalled sample chamber (size specified at time of order), optional chambers are available and easily retrofit by the user.
...Engineered with new technology incorporating the s... for unsurpassed flexibility, the new Varian NMR S... available today., ,The Varian NMR System feat... receiver channel, providing pulse sequence progra...
Pro-mix l-[35S]in vitro cell labeling mix, 92.5 MBq, 2.5 mCi. *Aqueous solution stabilized with 0.1% 2-mercaptoethanol and 15 mM pyridine 3,4-dicarboxylic acid. *Amino acid mixture for in vitro pro
...MMP-3, Human, Assay, 96 wells. ELISA.Specific for...d complexed MMP-3. No cross-reactivity with MMP-1,...ng/ml.Suitable for use with cell culture supernata...l.Store at -15 to -30 C. Category: Drug Screening...
Biology Products: