Navigation Links
Study identifies new role for breast cancer susceptibility gene

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression. The findings demonstrate that, in addition to an impaired DNA damage response associated with cancer initiation, mutation of BRCA1 is also linked to manipulation of the tumor microenvironment. The research appears in the July issue of Cancer Cell, published by Cell Press.

Mutations in the breast cancer susceptibility gene BRCA1 account for up to 50% of hereditary breast cancers. BRCA1 is known to serve as a tumor suppressor by regulating DNA damage repair and maintaining genomic stability. Although the mechanism is not fully understood, reduced BRCA1 expression is also often correlated with accelerated growth and progression of breast tumors and with increased tumor blood vessel formation. In order to better understand the link between BRCA1 and tumor progression, Dr. Wen-Hwa Lee and colleagues from the Department of Biological Chemistry at the University of California, Irvine, designed a series of experiments to search for genes that are regulated by BRCA1.

The researchers used microarray analyses to identify genes repressed by BRCA1 or a related tumor suppressor, CtIP, in mammary epithelial cells (MECs). Among the 12 genes inhibited by BRCA1 or CtIP was the gene for a secreted factor, called ANG1, that enhances blood vessel growth and maturation. The researchers found that a defect in a repressor complex formed by BRCA1, CtIP, and another known transcription repressor, ZBRK1, released the gene for ANG1 from repression and promoted survival of neighboring blood vessel cells and formation of capillary-like structures. Further studies demonstrated that mouse mammary tumors deficient in BRCA1 display high levels of ANG1 expression, prominent vascularization, and accelerated growth.

"Our study finds that BRCA1 possesses a role in tumor suppression bey ond maintaining genomic stability by regulating intercellular signaling within the tissue microenvironment. This view will extend BRCA1's tumor suppression function to the surroundings that influence the fate of neighboring cells and fortify the pathogenic relevance of its defect to neoplastic growth," concludes Dr. Lee.


'"/>

Source:Cell Press


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... Prairie, WI (PRWEB) , ... June 23, 2016 ... ... consultancy focused on quality, regulatory and technical consulting, provides a free webinar ... is presented on July 13, 2016 at 12pm CT at no charge. , ...
(Date:6/22/2016)... 22, 2016 Cell Applications, Inc. and ... to produce up to one billion human induced ... one week. These high-quality, consistent stem cells enable ... and spend more time doing meaningful, relevant research. ... high-volume manufacturing process that produces affordable, reliable HiPSC ...
Breaking Biology Technology: