Navigation Links
Study identifies new role for breast cancer susceptibility gene

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression. The findings demonstrate that, in addition to an impaired DNA damage response associated with cancer initiation, mutation of BRCA1 is also linked to manipulation of the tumor microenvironment. The research appears in the July issue of Cancer Cell, published by Cell Press.

Mutations in the breast cancer susceptibility gene BRCA1 account for up to 50% of hereditary breast cancers. BRCA1 is known to serve as a tumor suppressor by regulating DNA damage repair and maintaining genomic stability. Although the mechanism is not fully understood, reduced BRCA1 expression is also often correlated with accelerated growth and progression of breast tumors and with increased tumor blood vessel formation. In order to better understand the link between BRCA1 and tumor progression, Dr. Wen-Hwa Lee and colleagues from the Department of Biological Chemistry at the University of California, Irvine, designed a series of experiments to search for genes that are regulated by BRCA1.

The researchers used microarray analyses to identify genes repressed by BRCA1 or a related tumor suppressor, CtIP, in mammary epithelial cells (MECs). Among the 12 genes inhibited by BRCA1 or CtIP was the gene for a secreted factor, called ANG1, that enhances blood vessel growth and maturation. The researchers found that a defect in a repressor complex formed by BRCA1, CtIP, and another known transcription repressor, ZBRK1, released the gene for ANG1 from repression and promoted survival of neighboring blood vessel cells and formation of capillary-like structures. Further studies demonstrated that mouse mammary tumors deficient in BRCA1 display high levels of ANG1 expression, prominent vascularization, and accelerated growth.

"Our study finds that BRCA1 possesses a role in tumor suppression bey ond maintaining genomic stability by regulating intercellular signaling within the tissue microenvironment. This view will extend BRCA1's tumor suppression function to the surroundings that influence the fate of neighboring cells and fortify the pathogenic relevance of its defect to neoplastic growth," concludes Dr. Lee.


'"/>

Source:Cell Press


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... , ... Any expert in stem cell research or stem cell medicine knows ... a century. Despite their essential roles in human health and regenerative medicine, adult ... developed for this purpose also tag other, more abundant, non-stem tissue cells ( See ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... threatened by various biotic and abiotic factors. During this educational webinar, participants will ... coffee, as well as gain a better understanding of how genomics is important ...
(Date:8/14/2017)... ... August 14, 2017 , ... Opal Kelly, a leading ... PCI Express, announced the release of SYZYGY™, a new open standard for connecting ... for a compact, low cost, low pin-count, high-performance connectivity solution between FPGAs and ...
(Date:8/11/2017)... ... 11, 2017 , ... A staple in the community for more than 60 ... key elements including a new digital marketing strategy and updated logo. , As part ... has partnered with the South Texas Blood & Tissue Center for the month of ...
Breaking Biology Technology: