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Study hints at role of stem cell genes in testicular, breast cancers

breast carcinoma expressed all four genes.

The scientists suspect that expression of the genes may be elevated in other non-reproductive cancers, as well, such as those of the prostate. Studies have shown, says Clark, that OCT 4, which works with NANOG to regulate the capacity of cells to specialize, causes dysplatic lesions in the intestines, skin and stomach. "It would be useful to look at NANOG in those places where we know over expression of OCT 4 results in tumor progression," she says. "It may be playing a role there, too."

Other co-authors of the study were Uche I. Ezeh, MD, UCSF clinical instructor of physiology, and Paul J. Turek, MD, UCSF associate professor of urology.


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Source:University of California - San Francisco


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