Navigation Links
Study hints at role of stem cell genes in testicular, breast cancers

tion of sperm-producing germ cells.

Next, turning to cancerous tissue outside of the reproductive system, in this case breast tissue, the team determined, to their surprise, that the expression of the genes was active there, too.

"We thought this was going to be a phenomenon unique to germ cell tumors," says the senior author of the study, Amander Clark, PhD, assistant research geneticist in the laboratory of co-author Renee Reijo Pera, PhD, associate professor of obstetrics, gynecology and reproductive sciences and co-director of the UCSF Human Embryonic Stem Cell Center.

"This is the first indication that these genes are markers of breast cancer. The finding might lead to information about where breast cancers come from," Clark adds. "Are they derived from an original stem cell population, one that is expressing these genes, or do the cells in the tumor represent normal cells that have reverted to a more embryonic state that would express these genes?"

The suggestion that embryonic stem cell genes play a role in some cancers is not surprising. Embryonic stem cells, which emerge in the first five to seven days of the embryo's development, undergo a series of steps in which they selectively "turn on," or "express," genes that cause the cells progressively to assume the characteristics of a particular cell type, such as that of the skin, heart or brain. Cancers, meanwhile, develop when particular genes that regulate cell growth become misregulated, leading a cell to begin proliferating excessively. Misregulated embryonic stem cell genes, scientists have reasoned, could cause or advance cancer.

Substantial evidence already suggests, in fact, that genes in adult stem cells ?which reside in many tissues of the body ?cause some leukemias, and that they may cause gliomas, the most common form of brain tumor (UCSF - Nature, Feb. 19, 2004 ; UCSF - New England Journal of Medicine, Aug. 25, 2005).

The current study evolved from
'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study hints role stem cell genes testicular breast cancers

(Date:5/22/2013)... feared Legionella pneumophila bacteria is responsible for ... In order to infect us, this pathogen has developed ... go unnoticed in our cells, thus avoiding these acting ... Basque biosciences research centre, CIC bioGUNE, in which teams ... USA and the National Supercomputation Centre in Barcelona (BSC) ...
(Date:5/22/2013)... May 22, 2013. Plastic additives known as phthalates ... everywhere: They turn up in flooring, plastic cups, ... the Centers for Disease Control and Preventionthe bodies ... have come under increasing scrutiny. A growing collection ... can leech from packaging and mix with food) ...
(Date:5/21/2013)... A new analysis shows that the nation,s land ... enough algae to produce up to 25 billion gallons ... one-twelfth of the country,s yearly needs. , The findings ... that would be needed to grow significant amounts of ... were published in the May 7 issue of ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 4
... burned your finger on a hot stove? Imagine what it's ... feet all the time and know there's virtually nothing you ... it's a common complication of many diseases and medical conditions, ... pain, which is caused by damage to sensory neurons that ...
... biochemists reveal the first structural details of a family ... present in a variety of bacteria. The discovery was ... is the first look at how microcompartments are built, ... Yeates, UCLA professor of chemistry and biochemistry, and a ...
... The recent discovery of citrus greening (huanglongbing) in samples ... threat to Florida's $9 billion commercial citrus industry. Proper ... amount of crop loss caused by this disease, say ... greening is a bacterial disease that affects the phloem ...
Cached Biology News:Scientists use gene transfer technology and common virus to block neuropathic pain 2Scientists use gene transfer technology and common virus to block neuropathic pain 3Scientists use gene transfer technology and common virus to block neuropathic pain 4Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss 2Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss 3
(Date:5/22/2013)... 22, 2013   Oligomerix, Inc. , a ... modifying therapeutics for Alzheimer,s disease (AD) and related ... Series B financing, which includes both issuance of ... represent approximately $2.8M in new investments in the ... the raise. Funding from the ...
(Date:5/22/2013)... NEW ORLEANS , May 22, 2013 /PRNewswire/ ... regenerative medicine, presented new data generated in collaboration with ... leading health economics consultancy) demonstrating the significant healthcare resource ... venous leg ulcers (VLU) place upon the US healthcare ... which reveal annual costs of up to $15 billion ...
(Date:5/22/2013)... May 22, 2013 AudioNotch ... therapy for tinnitus treatment. AudioNotch is pleased to ... With clinic locations in both British Columbia and ... audiology and hearing services. AudioNotch's tinnitus treatment program ... Upon entering a Destination Hearing clinic, patients have ...
(Date:5/22/2013)... Alton Housing Authority was hit by bed ... that their presence has already caused the company $35,000 ... such big spending, My Cleaning Products shared a way ... said in the report that to clear the infestation ... that, its employees also attended a mandatory training on bed ...
Breaking Biology Technology:Oligomerix, Inc. Completes Series B Financing 2Oligomerix, Inc. Completes Series B Financing 3Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 2Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 3Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 4AudioNotch Tinnitus Treatment Launches Partnership With Destination Hearing 2Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2
... ) today announced the Webcast of its fourth quarter and year-end 2008 ... on Tuesday, February 10, and will include remarks by Peer M. Schatz, ... What: Webcast of QIAGEN,s fourth quarter ... results call, When: ...
... Commence Tender Offer for All Shares of Common StockAt ... Feb. 3 PharmaNet Development Group, Inc. (the "Company" ... provider of clinical development services, today announced that it ... affiliates of JLL Partners, Inc. ("JLL"). Under the terms ...
... Therapeutic Approach Provides HIV-Resistant Immune CellsRICHMOND, Calif., Feb. 3 ... announced today that its collaborators at the University ... trial to evaluate SB-728-T for the treatment of HIV/AIDS. ... technology, SB-728-T has been shown in an animal ...
Cached Biology Technology:Webcast of QIAGEN N.V.'s (Nasdaq: QGEN) Fourth Quarter and Year-End 2008 Financial Results Call Set for February 10 2PharmaNet Development Group Agrees to be Acquired by JLL Partners 2PharmaNet Development Group Agrees to be Acquired by JLL Partners 3PharmaNet Development Group Agrees to be Acquired by JLL Partners 4PharmaNet Development Group Agrees to be Acquired by JLL Partners 5PharmaNet Development Group Agrees to be Acquired by JLL Partners 6PharmaNet Development Group Agrees to be Acquired by JLL Partners 7Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS 2Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS 3Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS 4Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS 5Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS 6Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS 7
... DNA Ladder is suitable for ... to 16 kb by agarose ... can be visualized by ethidium ... be detected on Southern blots ...
...
... Hormone Receptor 2 ( Abpromise ... Antigen: Synthetic peptide: AFRHCNPNGTWDFMHSLN, ... of Human Parathyroid Hormone Receptor 2 ... 5746 Swiss ...
... 5 ml Dynabeads Mouse pan ... anti-B220 monoclonal antibody. For the efficient ... B cells directly from spleen or ... is expressed on mouse B cells ...
Biology Products: