Navigation Links
Study hints at role of stem cell genes in testicular, breast cancers

tion of sperm-producing germ cells.

Next, turning to cancerous tissue outside of the reproductive system, in this case breast tissue, the team determined, to their surprise, that the expression of the genes was active there, too.

"We thought this was going to be a phenomenon unique to germ cell tumors," says the senior author of the study, Amander Clark, PhD, assistant research geneticist in the laboratory of co-author Renee Reijo Pera, PhD, associate professor of obstetrics, gynecology and reproductive sciences and co-director of the UCSF Human Embryonic Stem Cell Center.

"This is the first indication that these genes are markers of breast cancer. The finding might lead to information about where breast cancers come from," Clark adds. "Are they derived from an original stem cell population, one that is expressing these genes, or do the cells in the tumor represent normal cells that have reverted to a more embryonic state that would express these genes?"

The suggestion that embryonic stem cell genes play a role in some cancers is not surprising. Embryonic stem cells, which emerge in the first five to seven days of the embryo's development, undergo a series of steps in which they selectively "turn on," or "express," genes that cause the cells progressively to assume the characteristics of a particular cell type, such as that of the skin, heart or brain. Cancers, meanwhile, develop when particular genes that regulate cell growth become misregulated, leading a cell to begin proliferating excessively. Misregulated embryonic stem cell genes, scientists have reasoned, could cause or advance cancer.

Substantial evidence already suggests, in fact, that genes in adult stem cells ?which reside in many tissues of the body ?cause some leukemias, and that they may cause gliomas, the most common form of brain tumor (UCSF - Nature, Feb. 19, 2004 ; UCSF - New England Journal of Medicine, Aug. 25, 2005).

The current study evolved from
'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study hints role stem cell genes testicular breast cancers

(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
(Date:7/11/2014)... brains of all vertebrates, information is transmitted through ... chemical signal to be passed from one brain ... most abundant type of synapse, can be either ... learning, memory, perception and cognition, and the balance ... function. For instance, every time we learn ...
(Date:7/10/2014)... 2014  Pomerantz LLP has filed a class ... the "Company")(NYSE-MKT: PVCT) and certain of its officers.  ... Court, Middle District of Tennessee ... class consisting of all persons or entities who ... 17, 2013 and May 22, 2014, both dates ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... newly identified human bocavirus was found in nearly 5 ... very young children. Researchers from the Centers for ... the International Conference on Emerging Infectious Diseases , "Our ... with pneumonia in Thailand, especially among young children," says ...
... by the National Institute of Allergy and Infectious Diseases ... have identified a defect in the immune response of ... them at risk of developing serious complications following smallpox ... the National Jewish Medical and Research Center in Denver, ...
... experts who attended a national avian flu conference last fall ... able to manufacture and stockpile enough vaccine or antiviral medication ... into a form that can be spread easily from human ... Carnegie Mellon University. The results of the survey will be ...
Cached Biology News:Bocavirus infection may be associated with pneumonia in Thailand, especially in children 2Defective immune system response to smallpox vaccine detailed in new study 2Defective immune system response to smallpox vaccine detailed in new study 3Medical experts: US unlikely to have enough vaccines to stop avian flu 2
(Date:7/10/2014)... even geckos and spiders can sit upside down forever. Nanophysics ... demonstrated this in an article just published in Physical ... benefit. , Geckos and spiders that seem to be able ... fascinated researchers worldwide for many years. We will soon be ... way as the gecko,s foot. But the fact is, sooner ...
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... Using an approach akin to assembling a club ... and Technology (NIST) researchers have succeeded in crafting ... the flammability of foam commonly used in upholstered ... of the nanotube-coated polyurethane foam was reduced 35 ...
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group ... is teaming up with the Heartland Blood Center and offering ... drive. The drive takes place Saturday, Jan. 18 at the ... 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
Breaking Biology Technology:Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... its recent analysis of the elastic nonwovens market, Frost & ... Frost & Sullivan Technology Leadership of the Year Award for ... styrenic block copolymers (SBCs). Already established as an innovator in ... of SBCs, the MD6705, G1643, and MD6717 grades are in ...
... Inc. (Nasdaq: CRTX ), a specialty pharmaceutical ... primarily for the respiratory market, today announced that Craig ... presenting a corporate overview at BioCentury,s 16th Annual Future ... EDT on Thursday, April 2, 2009, at the Millennium ...
... important provisional patent applicationsTAMPA, Fla., March 31 ... in cancer immunotherapy, has recently filed two provisional ... immunotherapy. The company,s research is focused on the ... specifically, iLRP - immature Laminin Receptor Protein, as ...
Cached Biology Technology:Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 2Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 3Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 4Frost & Sullivan Recognizes Kraton Polymers for Developing a New Generation of Polymer Grades Suitable for High-Speed Processing in Nonwoven Manufacture 5Cornerstone Therapeutics to Present at BioCentury's 2009 Future Leaders in the Biotech Industry Conference 2Immunotherapy-Based Provisional Patents Mark Significant Discovery 2Immunotherapy-Based Provisional Patents Mark Significant Discovery 3
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
Rabbit polyclonal to LCAT ( Abpromise for all tested applications). entrezGeneID: 3931 SwissProtID: P04180...
Sheep polyclonal to Malate Dehydrogenase ( Abpromise for all tested applications). Antigen: Full length protein - Pig heart malate dehydrogenase. Entrez Gene ID: 4190 Swiss Protein ID: P...
Mouse monoclonal [7E10] to C Peptide ( Abpromise for all tested applications). entrezGeneID: 3630 SwissProtID: P01308...
Biology Products: