Navigation Links
Study hints at role of stem cell genes in testicular, breast cancers

UCSF scientists have discovered that the activity of several embryonic stem cell genes is elevated in testicular and breast cancers, providing some of the first molecular evidence of a link between embryonic stem cells and cancer.

The finding, reported in the November issue of Cancer, suggests that the genes may play a role in the development of tumors or serve as valuable markers of tumor progression, the researchers say. As such, the genes ultimately could lead to new targets for therapy or markers for diagnosis.

A next step, according to the researchers, will be to "dig deeper" to determine the functions of the genes in the cells that make up the tumors.

Another step will be to explore whether the genes are expressed in other cancers, such as prostate cancer.

The genes are known as OCT 4, NANOG, STELLAR and GDF3.

The researchers focused on seminomas ?tumors that account for 50 percent of the cases of testicular cancer, the most frequent cancer in Caucasian males ages 15-40 -- and breast cancers, as represented by a sample of breast cancer cells grown in the culture dish and tissue from a Stage 3 breast tumor.

Previously, the team had discovered that expression of the genes was elevated in two samples of seminomas (Stem Cells, March 2004). In the current study, they expanded their investigation, determining that the expression of the genes was elevated, at varying levels, in nine seminomas.

In the process, they identified the "window" during which seminomas begin to develop. Scientists have known that seminomas arise in sperm-producing germ cells, which are located in the testis and produce sperm in boys following puberty. Germ cells, like all cells of the body, develop from embryonic stem cells, and go through a multi-stage evolution in their structure and genetic activity before attaining their mature state. The study revealed that the genetic misregulation leading to seminomas begins very early in the forma
'"/>

Source:University of California - San Francisco


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study hints role stem cell genes testicular breast cancers

(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... 7, 2014  In conjunction with the Glendale ... The Community Foundation of the Verdugos has announced the " ... PROJECT," a $250,000 initiative to keep the Verdugo Regional Crime ... first six months of existence, the Lab has processed more ... local law enforcement. "Because our number one priority ...
(Date:11/6/2014)... 6, 2014 - Insilico Medicine, Inc, a Baltimore-based ... age related diseases announced a research collaboration with ... Champions Oncology, Inc (OTC: CSBR). , "There are ... medicine, but Champions Oncology,s TumorGraft technology is unique ... chemotherapy regimen experimentally generating vast amounts of valuable ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... shady pursuit of endangered bird eggs made international headlines ... most notorious illegal egg collector, died after falling from ... The Royal Society for the Protection of Birds estimates ... are targeted by collectors. Classical economics theory predicts that ...
... world's oceans to land about 415 million years ago, then ... record contains few examples of animals with backbones for the ... again, this time for good. , The mysterious lull in ... for the Yale University paleontologist, Alfred Romer, who first recognized ...
... games this holiday season because the fun of playing ... , Psychologists at the University of Rochester, in collaboration ... 1,000 gamers what motivates them to keep playing. The ... month suggest that people enjoy video games because they ...
Cached Biology News:A human taste for rarity spells disaster for endangered species 2A human taste for rarity spells disaster for endangered species 3Steep oxygen decline halted first land colonization by Earth's sea creatures 2A reason why video games are hard to give up 2
(Date:11/26/2014)... NJ (PRWEB) November 25, 2014 ... has officially joined the Morris County (New Jersey) ... which is a leading business organization in the ... opportunity to further engage some key clients in ... operations in the geographic area. Membership enables Whitehouse ...
(Date:11/26/2014)... The Pittcon marketing department is pleased to announce ... app, Pittcon 2015 . The ... for iOS and Android devices and the Kindle Fire, ... after the event. It acts as an all-inclusive real-time ... Conferee Networking sessions and short courses. , The Pittcon ...
(Date:11/26/2014)... and WILMINGTON, DE (PRWEB) November 26, 2014 ... Annual MPN Heroes recognition reception on December 5, 2014, ... Hematology’s annual meeting. The MPN Heroes event will honor ... in the field of myeloproliferative neoplasms (MPNs). , ... "Nashville," will discuss his family's cancer journey at the ...
(Date:11/26/2014)... TOKYO , 25 novembre 2014 /PRNewswrie/ -- Theravalues ... per il mercato europeo in occasione di Hi Europe ... ). Si tratta della curcumina con ... tecnologia amorfa (senza cristalli) e ingredienti approvati dalle norme ... presente nella spezia della pianta curcumina ( Curcuma longa ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... October 20 Speaking in Rome, Italy today ... Foundation,(IOF) CEO Patrice McKenney called for individuals and ... osteoporosis. "Osteoporosis is a common but,devastating disease which ... taken to reduce the burden of osteoporotic fractures ...
... Air Force-funded researcher, Dr. scar Custance from the National Institute ... 2009 Feynman Prize for Experimental Work in Nanotechnology for his ... research could someday lead to more effective catalysts for the ... experimental work will be awarded in January 2010 near Palo ...
... Neurobiological Technologies, Inc. (Nasdaq: NTII ) ("NTI") announced ... Market LLC ("NASDAQ") that NTI intends to file a Form ... about October 28, 2009 to effect the voluntary delisting of ... dissolution of the company pursuant to a Plan of Complete ...
Cached Biology Technology:World Osteoporosis Day Call for Immediate Action to Prevent Fractures 2Researcher honored for experimental work in nanotechnology 2
... a DNA sequencing service. We can sequence ... products, BACs, etc. Our DNA sequencing service ... plasmids or purified PCR products. We use ... automated reaction setup and dye terminator removal. ...
... The BD FACSAria cell sorter sets ... cytometry. Based on a revolutionary new ... delivers high-speed sorting and multicolor analysis. The ... sorter that incorporates a fixed-alignment cuvette flow ...
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
...
Biology Products: