Navigation Links
Study finds how organs monitor themselves during early development

How are you? In biological terms this question could involve a feedback loop that lets the body check in on itself and then act on that information. Although feedback loops are essential and they abound in biology, they aren't well understood. Feedback loops enable an organ such as the liver to detect if it is injured, ascertain if it is growing and developing normally, and if it needs to regenerate itself. When such loops derail, cancer and other diseases can arise.

Scientists at NYU School of Medicine have unraveled the signals in a feedback loop governing ovarian development. This work has been several years in the making and is being published on 27 August in the Advance Online issue of the journal Nature.

"I think our study has indeed important implications that extend beyond understanding of how a gonad such as the ovary develops," explains Dr. Ruth Lehmann, Ph.D., Julius Raynes Professor of Developmental Genetics and Howard Hughes Medical Investigator. "In every organ, may it be a gonad, a liver, or a thymus, different tissues contribute to the organ, and the growth of the different tissues has to be coordinated both during normal development and during regeneration."

Tapping into that kind of powerful feedback loop could help treat many kinds of disorders and show how the power of stem cells could be harnessed to help organs call different cell types into action and regenerate, the researchers said. Stem cells are cells that have not yet specialized and can develop into any number of different cell types. They also have the remarkable ability to self-renew indefinitely.

The organism studied is one that does not enjoy much public appreciation but is favored in many genetics labs: Drosophila melanogaster, the fruit fly. Dr. Lehmann and post-doctoral fellow Lilach Gilboa, Ph.D., decoded the process in the developing fruit fly ovary that allows the ovary to monitor the number of germ cells it contains and to correct that n
'"/>

Source:New York University Medical Center and School of Medicine


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:12/17/2014)... 15, 2014  HITLAB SM announced today ... audit to confirm its adherence to current U.S. ... enables HITLAB to conduct regulated smart device and ... for patient safety and research quality. ... quality, and delivery with innovative technology," said ...
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... from the north-central U.S. and beyond will convene in Kalamazoo, ... and discuss new science, expand on existing science, and explore ... a special emphasis on the Great Lakes. Events include a ... by William F. Ruddiman titled, "When Did We Transform Earth,s ...
... York, NY (April 18, 2013) An excess of ... psychosis in people who are at risk for schizophrenia, ... Center (CUMC) published in the current issue of ... diagnostic tool for identifying those at risk for schizophrenia ...
... IOF Medal of Achievement has been presented today to ... Department of Internal Medicine, Hospital del Mar, Director of ... Institute of Medical Research and Professor of Medicine at ... Foundation (IOF) awards the IOF Medal of Achievement every ...
Cached Biology News:Kalamazoo center of geologic focus this May 2High levels of glutamate in brain may kick-start schizophrenia 2IOF Medal of Achievement awarded to Professor Adolfo Diez-Perez 2
(Date:12/24/2014)... The report expects global cell isolation and expansion ... provides a carefully analyzed data about the vital drivers, ... , Full Copy of Report @ http://bit.ly/1yUxy0T ... cell expansion will keep witnessing growth at an impressive ... be driven by rapid technological advancements, government funding and ...
(Date:12/24/2014)... 23, 2014 China Biologic Products, Inc. ... leading fully integrated plasma-based biopharmaceutical company in ... majority-owned subsidiary, Shandong Taibang Biological Products Co. Ltd., ... the China Food and Drug Administration (the "CFDA") ... previously disclosed in the Company,s public filings, the ...
(Date:12/24/2014)... -- PharmaBoardroom,s new report, , Healthcare ... for free download , digs deep into this vibrant ... the sector today. One area where ... developing a homegrown pharmaceutical manufacturing base, even if the government,s ... way off. A cursory comparison with neighboring Morocco ...
(Date:12/24/2014)... SARASOTA, Fla. , Dec. 23, 2014  Rock ... today that it has filed a Clinical Trial Application ... Medicines Healthcare products Regulatory Agency (MHRA) seeking regulatory approval ... its lead molecule, Anatabine Citrate. Contingent on ... to conduct a Phase I trial to assess the ...
Breaking Biology Technology:The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3
... CryoLife, Inc. (NYSE: CRY ),a biomaterials, medical device ... to participate in the 19th Annual Piper Jaffray,Health Care ... on Tuesday,November 27, 2007. Steven G. Anderson, president ... beginning at approximately 1:30 p.m. EST. CryoLife,s live ...
... pm ET on November 27, 2007, CAMBRIDGE, Mass., ... today announced its participation,in the Lazard Capital Markets Fourth ... at the New York Palace Hotel in New York,City. ... be presenting at 2:00 pm ET on Tuesday, November ...
... Scientists have announced,that they successfully reprogrammed adult ... of patient-specific medical treatments and,research without the need ... the Discovery Institute,s Senior Fellow in Bioethics,and author ... hailed the,breakthrough as demonstrating that ethical science is ...
Cached Biology Technology:CryoLife to Present at 19th Annual Piper Jaffray Health Care Conference in New York 2Targanta to Present at Lazard Capital Markets Fourth Annual Healthcare Conference 2
... new product number, created to easily match ... yet, please order under the old Sigma-Aldrich ... assistance. ID clarifier: tissue-culture treated ... cm 2 D H 245 ...
... Novagens PhageMaker System is optimized for maximum ... ligated with any bacteriophage l vector. Using a ... > 10^7 pfu/g arms (> 4 x 10^8 ... This one-tube system is extremely easy to use; ...
Mouse monoclonal [7B9] to beta II Tubulin ( Abpromise for all tested applications). Antigen: Synthetic peptide, CEEEEGEDEA found at the c-terminus of beta II tubulin. Entrez GeneID: 10383 ...
Polymerase (RNA) II (DNA directed) polypeptide L...
Biology Products: