Navigation Links
Study finds how organs monitor themselves during early development

How are you? In biological terms this question could involve a feedback loop that lets the body check in on itself and then act on that information. Although feedback loops are essential and they abound in biology, they aren't well understood. Feedback loops enable an organ such as the liver to detect if it is injured, ascertain if it is growing and developing normally, and if it needs to regenerate itself. When such loops derail, cancer and other diseases can arise.

Scientists at NYU School of Medicine have unraveled the signals in a feedback loop governing ovarian development. This work has been several years in the making and is being published on 27 August in the Advance Online issue of the journal Nature.

"I think our study has indeed important implications that extend beyond understanding of how a gonad such as the ovary develops," explains Dr. Ruth Lehmann, Ph.D., Julius Raynes Professor of Developmental Genetics and Howard Hughes Medical Investigator. "In every organ, may it be a gonad, a liver, or a thymus, different tissues contribute to the organ, and the growth of the different tissues has to be coordinated both during normal development and during regeneration."

Tapping into that kind of powerful feedback loop could help treat many kinds of disorders and show how the power of stem cells could be harnessed to help organs call different cell types into action and regenerate, the researchers said. Stem cells are cells that have not yet specialized and can develop into any number of different cell types. They also have the remarkable ability to self-renew indefinitely.

The organism studied is one that does not enjoy much public appreciation but is favored in many genetics labs: Drosophila melanogaster, the fruit fly. Dr. Lehmann and post-doctoral fellow Lilach Gilboa, Ph.D., decoded the process in the developing fruit fly ovary that allows the ovary to monitor the number of germ cells it contains and to correct that n
'"/>

Source:New York University Medical Center and School of Medicine


Page: 1 2 3 4

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:7/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ... "Global Outlook of the Biometrics Industry 2015 " ... The global biometrics market is likely to witness ... owing to the uptake of multiple technologies available. ... enhances the growth of biometrics in existing applications ...
(Date:7/13/2015)... SAN JOSE, Calif. , July 13, 2015 ... the leading developer of human interface solutions, today ... second generation touch and display driver integration (TDDI) ... solution is the first to combine Synaptics , ... expertise with proven display driver technology developed in ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... the breakdown of cognition processes and typical emotional and ... believe that several genes are associated with an increased ... the disease by itself. It is likely that interactions ... to develop and that epigenetic change also plays a ...
... Studies and the Woodrow Wilson International Center for Scholars ... Science Foundation (NSF) to help realize potential benefits and ... The grant is supported jointly by three ... Biology, the Division of Environmental Biology, and the Engineering ...
... generally deleterious, even in flowering plants. Since inbreeding raises ... be expressed, inbred progeny suffer from reduced viability. ... reject their own pollen, thereby preventing inbreeding despite the ... that involves the interaction of a gene that tags ...
Cached Biology News:How does inbreeding avoidance evolve in plants? 2
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... , the Company,s Chief Financial Officer has resigned.  The ... Chief Financial Officer who retired in December 2014, as ... for a permanent successor.     Andy Ashworth ... Laurin and ensure a smooth transition.  Andy was the ...
(Date:7/29/2015)... DUBLIN , July 29, 2015 ... ) has announced the addition of the ... to their offering. The Global Biosimilars ... study of the rapidly growing biosimilars market. With ... industry striving to minimize costs, biosimilars are being ...
(Date:7/29/2015)... , July 29, 2015  Pfenex Inc. (NYSE ... financial results will be released on Thursday, August 13, ... Eastern Time, Pfenex management will host a conference call ... update.  A press release outlining the financial results and ... call. Please call 1-866-376-8058 (US) or 1-412-542-4131 ...
(Date:7/29/2015)... 29, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... selected an optimized Erk inhibitor molecule for development, ... of a new class of potential cancer therapies. ... prime target for therapeutic intervention in cancer. Recently ... benefits for B-Raf and Mek inhibitors. Erk inhibitors ...
Breaking Biology Technology:BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3
... supply ordering system that allows users to create a ... order. ProSource then provides these items in one location ... order. ProSource eliminates the need to order from multiple ... from the same location, all while helping to eliminate ...
... CALGARY, Sept. 16 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc.,(TSX:SBS), ... for metabolic and cardiovascular diseases, today announced that ... I/II human clinical trial of,plant-produced insulin now that ... (IND) application has passed. SemBioSys submitted,the application in ...
... Development of influenza VLP vaccines gains momentum with launch of ... IIa study of ... Inc.,(Nasdaq: NVAX ) announced today vaccination of healthy volunteers ... based seasonal influenza,vaccine. The Phase IIa randomized, placebo controlled clinical ...
Cached Biology Technology:ProSource 2.0 Offers Value, Savings for Lab Supplies 2SemBioSys eligible to proceed with Phase I/II plant-produced insulin trial after submission of IND 2SemBioSys eligible to proceed with Phase I/II plant-produced insulin trial after submission of IND 3Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 2Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 3Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 4Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate 5
... ovens are designed to create the ideal environment ... (ambient to 99.9C) , Variable speed control ... samples, whether it be for washing or hybridizing ... current temperature inside the chamber, ,is situated above ...
... magnetic particle based purification systems provide high ... any sample. They offer increased throughput and ... systems- KingFisher, KingFisher mL and KingFisher 96, ... l. Each system consists of an instrument, ...
... is the latest edition to the famous ... an extra large diameter exhaust port for ... panel allows precise setting and control of ... handling large quantities and samples , ...
... Thermo Savant SpeedVac Concentrators set the standard ... SC110A SpeedVac uses a combination of centrifugal force, ... a single run., SC110A comes equipped with:, , ... chemical compatibility , ...
Biology Products: