Navigation Links
Study finds 60 new genes controlled by DNA snippet

three million times throughout the human DNA blueprint.

CArG boxes exert their influence over genes because they are "shaped" to partner with a nuclear factor called serum response factor (SRF) and several other proteins within a genetic regulatory network. Throughout a human life, such networks are believed to "decide" the timing and location of all gene expression, the process through which genetic information is converted into templates for protein construction.

The current study, funded through a grant from the National Heart, Lung and Blood Institute, sought to survey the human and mouse genome databases created by the Human Genome Project to find all CArG boxes that regulate genes. The sheer amount of information involved requires that such studies use high-powered computer programs to screen data. In this case, researchers used a high-speed screening to expand the definition of the functional mammalian CarGome, the complete set of CArG boxes that regulate genes.

In collaboration with Christian Stoeckert, Ph.D., associate professor of Genetics at the University of Pennsylvania, Miano's team designed a set of criteria that a given piece of DNA had to meet in order to be considered a functional CArG box. Thanks to their work and that of several other labs, they knew going in all the CArG box variations and how close they typically lie to the genes they regulate (within 4,000 base pairs).

The data-screening tool also employed comparative genomics, the study of relationships between the DNA of different species. When a piece of genetic material, gene or regulatory segment, is conserved by evolution from mice to humans it suggests that the segment has a valuable function. Miano's screen required that CArG boxes shared by humans and mice be included in his expanded version of the CarGome. CArG boxes identified by the computer screen were then tested to see if they indeed interacted with SRF and changed the behavior of genes as pred
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4 5

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
(Date:10/6/2008)... October 6, 2008 -- A research study funded by JDR...rovide some protection from developing type 1 diab...ds understanding how and why type 1 diabetes devel..., The study, reported this week in Nature Magaz...sis," that exposure to an appropriate amount and c...
(Date:10/6/2008)... LA Dr. Eugene Woltering, the James D. Rives Prof...ciences Center New Orleans School of Medicine, and...ysiology, have been awarded a US Patent for a comp...tical to the growth of cancerous tumors and diseas...is. , Apolipoprotein A-I is the major protein co...
(Date:10/6/2008)...ct. 6, 2008 Putting together the Who,s Who of bat...nown mammals was a gigantic task ably assisted by ...of the planet,s most extensive and diverse mammal ...ational Union for Conservation of Nature) is relea...ls, including assessments of diversity, threat and...
(Date:10/6/2008)... (Oct. 6, 2008) − The American Physiological...Fund to provide unrestricted grants of up to $2,00...doctoral fellows who suffered losses as a result o...coast on Sept. 13 and also affected other areas of...nts and fellows who are either APS members or work...
Breaking Biology News(10 mins):JDRF funded study links 'hygiene hypothesis' to diabetes prevention 2LSUHSC awarded patent for compound inhibiting cancer and other diseases 2Field Museum provides gold standard for mammal survey 2Field Museum provides gold standard for mammal survey 3Mental health linked to amputation risk in diabetic veterans 8601 1Mental health linked to amputation risk in diabetic veterans 8601 2Parents Smoking Boosts Childs Allergy Risk 8600 1Parents Smoking Boosts Childs Allergy Risk 8600 2The Long Term Care Insurance Explosion 3B January Conference to Celebrate Rapid Growth of LTC Protection and Light Fuse of Further Expansion 8598 1The Long Term Care Insurance Explosion 3B January Conference to Celebrate Rapid Growth of LTC Protection and Light Fuse of Further Expansion 8598 2Life Denied 3A California Nurses Family of Sick Teen March on Health Insurance Company Thursday 8596 1Life Denied 3A California Nurses Family of Sick Teen March on Health Insurance Company Thursday 8596 2
...dings with implications for pandemic influenza, a ...irulent strain of avian influenza virus can spread...the October 1 issue of The Journal of Infectious D...ies barrier is an important step in the developmen... studies have focused on the ability of highly pat...
... of the largest adult vaccine clinical trials ever...ine against shingles (zoster vaccine) prevented ab... skin infection--and dramatically reduced its seve...ot the disease. The findings appear in the June 2 ...e Shingles Prevention Study, conducted over 5 ½-ye...
...as in a pod may not be so friendly when planted in...once separated may treat the former conjoined twin...searcher. , "We were looking at how plants determi...oots for limited resources," says Dr. Omer Falik, ...s no reason for roots to fight if they belong to t...
...ists at the MUHC have made an important discovery ...ale hormone estrogen causes growth of breast cance...tists at the Institut de Recherches Cliniques de M...o estrogen and one in particular that can be used ...dy, published in today,s Proceedings of the Nation...
Other Biology News:Transplanting Animal Organs Could Soon Be A Reality 2Experimental shingles vaccine proves effective in nationwide study 2Experimental shingles vaccine proves effective in nationwide study 3Experimental shingles vaccine proves effective in nationwide study 4Plants discriminate between self and non self 2Scientists discover genetic pathway responsible for breast cancer cell growth 2
(Date:10/6/2008)... based in Los Angeles, California is anticipated t...ny,s ability to supply its new, generation of in...ure., LOS ANGELES, Oct. 6 /- Today, ...based in Barcelona, Spain, broke ground on a new,9...IG) production facility,at its manufacturing compl...
(Date:10/6/2008)...ST , Belgium, AHMEDABAD, India and GOTTINGEN, Germ...Research, genae associates,Cardiovascular Center ...to,form a Core Laboratories joint venture, called ...rmance of medical images,analysis for clinical res...titative coronary and peripheral angiography (QCA,...
(Date:10/6/2008)...and, Oct. 6 /- deCODE genet...mber 30, 2008 it received a,notice from the Nasdaq...ing,days the market value of deCODE,s common stock...uired for continued listing on The Nasdaq Global,M...(b)(1)(A). The notice,further stated that deCODE a...
(Date:10/6/2008).../- PAREXEL International,Co... be presenting at the,William Blair Small-Cap Grow...l, Senior Vice President and Chief Financial Offic... at 11:20 a.m. EDT on Tuesday, October 7,2008., ...ble under the,"Upcoming Events" section on PAREXEL...
Breaking Biology Technology:Grifols Breaks Ground on New IVIG Facility 2Core Laboratories Joint Venture Agreement Between genae associates, VIBGYOR Scientific Research, Cardiovascular Center Aalst and J.B. Dahm 2deCODE Receives Nasdaq Deficiency Notice Relating to Market Value 2deCODE Receives Nasdaq Deficiency Notice Relating to Market Value 3PAREXEL International to Present at William Blair Small-Cap Growth Stock Conference 2
..., , , , , R&D Department ,... , , , Gene expression profiling at ..., by microarray analysis and quantitative re...s the advantage of profiling expression levels of ...usly using asingle RNA preparation. Although real-...
..., , , , , , , , ,... using the QuantiTect SYBR Green RT-PCR , K...q DNA Polymerase with , a unique blend of S...Sensiscript , RT is designed for use with v... RT provides highly efficient reverse transcripti...
..., , , , , For purification of...DNA , , Classic QIAGEN Plasmid Kits...t , purification of plasmid DNA , ...nefits , , , ...sCl-gradient centrifugation , ,...
..., , , , , High-quality short ...nt , gene silencing in eukaryotic cell cult... mRNA. This effect, termed RNA interference (RNAi)...tional genomics studies. Now, QIAGEN offers a cust...e that includes a range of modifications , ...
Other Biology Technology:Critical factors for successful microarray and real-time PCR analyses 2Critical factors for successful microarray and real-time PCR analyses 3Critical factors for successful microarray and real-time PCR analyses 4Critical factors for successful microarray and real-time PCR analyses 5Critical factors for successful microarray and real-time PCR analyses 6Critical factors for successful microarray and real-time PCR analyses 7Critical factors for successful microarray and real-time PCR analyses 8Custom and library siRNA for efficient gene silencing 2Custom and library siRNA for efficient gene silencing 3Custom and library siRNA for efficient gene silencing 4
...g single-stranded RNA ranging from 0.5 kb to 10 kb...er consists of nine bands in even increments (0.5 ...tion. The 1.5 kb band is more intense than the oth...ion of RNA bands on the gel. All RNA molecules in ...
Recombinant Mouse Wnt-3a
Homo sapiens jumping translocation breakpoint
One-step, microplate or cuvet, colorimetric, detection range 0.01 g/dL to 5 g/dL. Procedure: 5 min.
Biology Products: