Navigation Links
Study finds 60 new genes controlled by DNA snippet

three million times throughout the human DNA blueprint.

CArG boxes exert their influence over genes because they are "shaped" to partner with a nuclear factor called serum response factor (SRF) and several other proteins within a genetic regulatory network. Throughout a human life, such networks are believed to "decide" the timing and location of all gene expression, the process through which genetic information is converted into templates for protein construction.

The current study, funded through a grant from the National Heart, Lung and Blood Institute, sought to survey the human and mouse genome databases created by the Human Genome Project to find all CArG boxes that regulate genes. The sheer amount of information involved requires that such studies use high-powered computer programs to screen data. In this case, researchers used a high-speed screening to expand the definition of the functional mammalian CarGome, the complete set of CArG boxes that regulate genes.

In collaboration with Christian Stoeckert, Ph.D., associate professor of Genetics at the University of Pennsylvania, Miano's team designed a set of criteria that a given piece of DNA had to meet in order to be considered a functional CArG box. Thanks to their work and that of several other labs, they knew going in all the CArG box variations and how close they typically lie to the genes they regulate (within 4,000 base pairs).

The data-screening tool also employed comparative genomics, the study of relationships between the DNA of different species. When a piece of genetic material, gene or regulatory segment, is conserved by evolution from mice to humans it suggests that the segment has a valuable function. Miano's screen required that CArG boxes shared by humans and mice be included in his expanded version of the CarGome. CArG boxes identified by the computer screen were then tested to see if they indeed interacted with SRF and changed the behavior of genes as pred
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4 5

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study finds new genes controlled DNA snippet

(Date:12/17/2014)... Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home ... to their offering. ... different sensing technology than the iPhone 5S, Samsung ... in its product. The Galaxy S5 ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... addition of the "Global Chemical Sensor Market ... http://photos.prnewswire.com/prnh/20130307/600769 One ... increasing demand for medical sensors in biomedical applications. ... for quick and correct diagnosis during surgical procedures. ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... DETROIT Diabetes Mellitus (DM), a metabolic disorder that ... chronic hyperglycemia that disrupts carbohydrate fat and protein metabolism ... both. DM can cause long-term damage, dysfunction and even ... may develop corneal complications and delayed wound healing. This ...
... Nuclear Magnetic Resonance (NMR) Spectroscopy is an extremely powerful ... by chemists from its origin, it is now essential ... scope extended in biological laboratories. Coupled with NMR, ... the enhancement of NMR signals from a wide range ...
... to five protective antigens, the presence of which are critical to ... been present in almost all isolates of Bordetella pertussis ... more than half of them, according to a paper published ahead ... "These findings tell us that there is an evolutionary advantage to ...
Cached Biology News:Wayne State discovers potential treatment for skin and corneal wound healing in diabetics 2A powder to enhance NMR signals 2Whooping cough vaccine antigen disappearing from bacteria in US 2
(Date:12/17/2014)... 2014 Gene synthesis and bioengineering ... entered into a technology access and services agreement ... DNA2.0’s proprietary protein engineering technology, known as “ProteinGPS®” ... are extremely excited that the global leader ADM ... proprietary bioengineering technology has now been validated through ...
(Date:12/17/2014)... 16, 2014  Vermillion, Inc. (NASDAQ: VRML ... today announced the next step in its expanded strategy ... provider with the naming of current Chief Operating Officer, ... Officer, while current Chairman of the Board and CEO ... Chairman. These changes are effective January 1, 2015. ...
(Date:12/17/2014)... 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... development and commercialization of innovative therapeutics addressing cancer and ... a primary commercial focus on China ... Type C meeting with the U.S. Food and Drug ... in February 2015.  During this meeting the Company will ...
(Date:12/17/2014)...   Synageva BioPharma Corp. (NASDAQ: ... rare disorders, announced today its presentation at the upcoming ... San Francisco, CA. Sanj ... present on Monday, January 12, 2015, at 9:00 a.m. ... live and may be accessed from the "Webcasts & ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5
... -- Good computer security requires careful attention not just to ... to Debbie Christofferson, president of Sapphire Security Services . ... it open a crack, or are all your windows open? ... conference in Milwaukee . , ,Referring to the title of ...
... MADISON - Some of the first data from a new ... and by analogy galaxies in general - is making new ... , ,The findings from NASA's Spitzer Space Telescope were announced ... Edward Churchwell, a University of Wisconsin-Madison astronomer and the leader ...
... Sonic Foundry s Mediasite have a home ... help organizations capture presentations digitally and publish them on the ... for Mediasite, the companies announced in statements released in tandem ... can leverage the power of rich media communications without the ...
Cached Biology Technology:Expert says network security is about people, not just computers 2Milky Way churning out new stars at a furious pace 2Milky Way churning out new stars at a furious pace 3BxVideo designs Web hosting service for Sonic Foundry media presentations 2
...
... contains the basic components required for the ... and recombinant rat Thymus Chemokine-1 in cell ... sufficient materials to run ELISAs on approximately ... conditions are met: The assay ...
Blimp-1 (H-150)...
Mouse Galectin-1 Affinity Purified Polyclonal Ab...
Biology Products: