Navigation Links
Study findings offer potential new targets for antibiotics

A new study of genetic changes in bacteria may ultimately help drug makers stay a step ahead of disease-causing bacteria that can become resistant to antibiotics.

The secret lies in understanding the function of the ribosome, a tiny protein-making factory residing inside most cells.

Many currently used antibiotics alter a ribosome's ability to make proteins, said Kurt Fredrick, a study co-author and an assistant professor of microbiology at Ohio State University.

But he and his colleagues at the University of Illinois thought that there may be additional places in a ribosome that future antibiotics could affect, places that current antibiotics don't currently target.

The researchers were right.

"Antibiotic resistance will always be an issue," Fredrick said. "But as long as we can stay ahead of the ability of the pathogens to resist antibiotics, we're okay."

The findings appear online this week in the Early Edition of the Proceedings of the National Academy of Sciences. Fredrick co-authored the study with lead author Alexander Mankin and with Aymen Yassin, both with the University of Illinois at Chicago.

Fredrick provided a strain of Escherichia coli important for the study.

In order to find out if their initial hunch was correct ?that there actually are other "hot spots" on a ribosome that could act as potential targets for antibiotics ?the researchers first introduced a mutated copy of the ribosomal genes into E. coli cells and looked for those rare mutations that could interfere with cell growth. It was known from previous studies that such deleterious mutations occurred within critical regions of the ribosome.

After identifying dozens of deleterious mutations, the researchers were able to produce a composite map showing where these mutations were positioned on the ribosomes. Interestingly, the map indicated that there were four additional places on ribosomes where these mutations clustered. Wh ile researchers already knew that these sites existed, they did not know that these areas could possibly become targets for antibiotics.

These sites are what may one day give pharmaceutical companies an edge in creating new antibiotics in order to keep ahead of bacteria's clever way of developing resistance to antibiotics.

"Now that we know these other sites exist and that they could be potential targets for antibiotics, the next step is to figure out how exactly these mutations interfere with the cell's own ribosomes," Fredrick said.


'"/>

Source:Ohio State University


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm ... Mold) microbial test has received AOAC Research Institute approval 061601. , “This is ... last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
Breaking Biology Technology: