Navigation Links
Study details hepatitis C ability to block immune system response

itis C virus inhibits the activity of naturally occurring interferon by shutting down a key antiviral signaling protein.

Early after HCV infection, the immune system responds to viral RNA by activating a signaling cascade in the infected cells that results in the production of type 1 interferon. One of the intermediaries in that cascade is a mitochondrial antiviral signaling protein (MAVS). HCV blocks the production of type1 interferon by using its protease activity to destroy MAVS. By preventing infected cells from producing interferon, the virus inhibits the body's immune response against HCV, enabling it to persist.

"Our new work shows that HCV does not induce interferon-? or antiviral interferon stimulated genes in the infected cells," Chisari said. "This means that the antiviral interferon stimulated genes expressed in the HCV-infected liver are likely produced by uninfected cells in some novel fashion and that the virus has other tricks up its sleeve that makes it resistant to their antiviral effects. Further study is needed to understand which cells in the liver produce the interferon and how the virus can resist the broad spectrum of these antiviral effects."

The knowledge gained from fundamental studies such as these could lay the groundwork for the development of potential new treatment strategies for this devastating global disease.


'"/>

Source:Scripps Research Institute


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study details hepatitis ability block immune system response

(Date:10/31/2014)... Bugnyar and his team have been studying the ... Northern Austrian Alps for years. They observed that ... as grooming and playing. However, they also observed ... a third individual. Although in about 50 % ... broke up the two affiliating ravens, intervening can ...
(Date:10/30/2014)... When most animals begin life, cells immediately begin accepting ... organ. However, mammals, including humans, are special. The cells ... choice – to become the protective placenta or to ... critical first step that research from Michigan State University ... current issue of PLOS Genetics , ...
(Date:10/30/2014)... developed a suite of technologies that can be used ... applications in everything from search and rescue to service ... platform for computer-mediated communication between humans and dogs that ... behavioral signals and sending them clear and unambiguous cues ... of computer science at NC State and co-lead author ...
Breaking Biology News(10 mins):Identifying the source of stem cells 2New tech aims to improve communication between dogs and humans 2
... release is available in Spanish . ... However, human nutrition researchers agree that many questions remain about ... Studies led by Agricultural Research Service (ARS) molecular biologist Daniel ... Certain kinds of inflammation can increase risk of cancer ...
... is available in Spanish . Researchers ... the Clinical Hospital San Cecilio and the University Rey Juan ... patients with tension headache improves within 24 hours after receiving ... an increasing incidence in the population. This type of disorder ...
... The ,Geographic Chemicals in Groundwaters and Soils, event ... Marie Curie Research Training Network. This network, coordinated ... to highlight the environmental effect including the effect ... in groundwater and soils. Held today and tomorrow ...
Cached Biology News:Luteolin stars in study of healthful plant compounds 2University of Manchester academics at international conference on geographic chemicals 2
(Date:10/30/2014)... CA (PRWEB) October 30, 2014 ... today that they have manually curated public data source ... non profit customers. the data is now available ... curates and unifies public and internal data sources for ... and knowledge out of the data that becomes more ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Spartan Bioscience ... Spartan RX CYP2C19 System . It detects CYP2C19 genetic ... cheek swab. , The Spartan RX CYP2C19 System is ... has been approved in Canada. Due to the system’s ... may be used by healthcare professionals such as doctors, ...
(Date:10/30/2014)... Avure Technologies celebrates a year of success and ... its fleet of high volume High Pressure Processing (HPP) systems. ... return to PackExpo this year, which is where we first ... Jeff Williams, CEO at Avure. “Sales of the new Avure ... meeting the challenges of market demand for higher throughput. We ...
(Date:10/30/2014)... 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ... will present a company overview at the Nomura Biotechnology Conference ... Boston, MA. A live ... & Media" section of the Company,s website, www.isispharm.com .  ... 48 hours and will be archived for a limited time. ...
Breaking Biology Technology:Rancho BioSciences Manually Curated TCGA Data Sets Available 2Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2
... BRUNSWICK, N.J. and NANJING, China, Sept. 3 ,Acesys ... combining the drug discovery expertise and project management,capabilities ... chemistry resources and,favorable cost structure of Acesys in ... alliance will encompass all,aspects of medicinal chemistry for ...
... strategic planner for an organization in the filter industry? ... Are you part of a filter company looking ... the growth segments in the filter and filtration markets. ... Place in Charlotte, NC, the American Filtration and Separations ...
... HOBOKEN, N.J. - Dr. Yong Shi of Stevens ... grant for his project titled "MEMS Umbrella-Shaped Actuator ... was approved on scientific/technical merit for three years ... the research is to design, fabricate and test ...
Cached Biology Technology:Acesys and Provid Announce Alliance for Medicinal Chemistry Services 2Filter Markets - Discover the Growth Segments 2Filter Markets - Discover the Growth Segments 3Dr. Yong Shi awarded NSF grant 2
...
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
... are macroporous polystyrene beads for hydrophobic interaction ... for adsorbing organics of molecular weight less ... are useful for the adsorption of nonpolar ... the removal of detergents such as Triton ...
... Immunogen : Fusion protein corresponding ... of human Mi-2 Formulation: 0.7M ... 0.035% sodium azide, containing 30% ... by immunoblot on Hela nuclear ...
Biology Products: