Navigation Links
Study details hepatitis C ability to block immune system response

The study was published in an advance online edition of the Proceedings of the National Academy of Sciences on May 17.

Hepatitis C virus (HCV) is a worldwide public health problem. The World Health Organization estimates that 170 million people worldwide are chronically infected and that between 3-4 million are newly infected annually. HCV is the leading cause of chronic liver disease including hepatic fibrosis, end-stage cirrhosis, and hepatocellular carcinoma. There is no vaccine available to prevent HCV, and current therapies are costly, have serious side effects and are curative in only a fraction of patients. According to the World Health Organization, the major causes of HCV infection are use of unscreened blood transfusions, and re-use of needles and syringes that have not been adequately sterilized.

Viral infections like hepatitis C often trigger an immediate innate immune response involving release of type 1 interferon (IFN-? and IFN-?). In turn, type 1 interferon stimulates the production of a family of what are known as IFN stimulated genes that have a multitude of inhibitory effects on viral replication in infected and neighboring uninfected cells. While interferon production and other immune responses can greatly influence the course of a number of different viral infections, many human pathogenic viruses have evolved distinct strategies to inhibit the early signaling events leading to interferon production. HCV is no different.

"We have previously demonstrated that many interferon stimulated genes with antiviral activity are induced in the liver during HCV infection," said Francis V. Chisari, M.D., a Scripps Research professor whose laboratory conducted the study. "Despite their induction, the virus can persist indefinitely, indicating that it is resistant to their antiviral effects."

The current study sheds light on one strategy the hepatitis C virus uses to resist the immune system. The findings suggest that the hepat
'"/>

Source:Scripps Research Institute


Page: 1 2

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study details hepatitis ability block immune system response

(Date:4/18/2014)... Ill. For the past 20 years, researchers have ... the research findings have suggested that soil organic carbon ... conventional tillage systems to no-till systems. However, there is ... systems in corn and soybean rotations without cover crops, ... organic carbon stocks at the published rates. , "Some ...
(Date:4/18/2014)... Calif. A team of researchers led by ... been selected to receive a $7.5 million Department of ... simple and basic scientific foundations for the predictable design ... a wide diversity of structures from plants and animals, ... are taking what biological systems have constructed over millions ...
(Date:4/17/2014)... there was a word for chili peppers. Information about ... with a study of the appearance of words for ... where jalapeos were domesticated and highlight the value of ... Kraft et al.) of nine papers presented in a ... National Academy of Sciences on plant and animal ...
Breaking Biology News(10 mins):Researchers question published no-till soil organic carbon sequestration rates 2Researchers question published no-till soil organic carbon sequestration rates 3Researchers question published no-till soil organic carbon sequestration rates 4Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3Chickens to chili peppers 2Chickens to chili peppers 3
... on biodiversity pose a serious conservation challenge for marine life, ... may need to relocate faster than land species as well ... cycle events. This challenges previous thinking that marine life in ... because of slower warming in the oceans. "Analyses of ...
... University of Cambridge study, which set out to investigate DNA ... our lifestyle and our health, has now mapped the link ... data collected greatly benefits a field that is still in ... where the researchers were, even 18 months ago. ...
... from UCLA,s cancer and stem cell centers have demonstrated for ... to create cancer-killing T-cells that seek out and attack a ... in 40 percent of Caucasians with this malignancy. Done ... blood stem cells, which make every cell type found in ...
Cached Biology News:No plain sailing for marine life as climate warms 2No plain sailing for marine life as climate warms 3Environment and diet leave their prints on the heart 2UCLA researchers engineer blood stem cells to fight melanoma 2UCLA researchers engineer blood stem cells to fight melanoma 3
(Date:1/14/2014)... UK (PRWEB) January 13, 2014 Bob ... with more than 20 years in the industry, has ... photonics . Hainsey will serve as the society’s Science ... Dr. Hainsey join SPIE as our Technology Strategist, further ...
(Date:1/14/2014)... 2014 During the 1600’s through the 1800’s ... Doctor’s Plague.” In this time period, doctors did not know ... times, to the death of vulnerable patients. In the same ... they may be unwittingly transmitting herpes viruses to their patients. ...
(Date:1/14/2014)... BioMedomics, Inc. , a Point of Care ... novel disease specific POC tests, announced today that it has ... of $690,000. The investment is from private investors and is ... of private investors has significant successful experience in early investments ...
(Date:1/14/2014)... Translational Biosciences, a subsidiary of ... trial approval for the treatment of rheumatoid arthritis ... from the Comité Nacional de Bioética de la ... (RA) is an autoimmune disease in which the ...
Breaking Biology Technology:Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3BioMedomics, Inc. Closes $690K Round of Financing 2Panama’s First Umbilical Cord Stem Cell Clinical Trial for Rheumatoid Arthritis Approved by Comité Nacional de Bioética de la Investigación Institutional Review Board 2Panama’s First Umbilical Cord Stem Cell Clinical Trial for Rheumatoid Arthritis Approved by Comité Nacional de Bioética de la Investigación Institutional Review Board 3
... ... Screening Capabilities Yield High-quality Data for the Broad Institute,s NIH-funded Molecular Libraries and Imaging ... Lexington, ... leading provider of in silico solutions for pharmaceutical R&D and related life sciences, today ...
... Oct. 5 Verenium Corporation (Nasdaq: VRNMD ), ... and high-performance specialty enzymes, today announced that it intends ... shares of its common stock, and potentially warrants, in ... to price before 9:30 am EDT on Tuesday, October ...
... UPPSALA, Sweden, October 5 , ... - At One Sixth the Price of QuanTyper(TM) Without Loss ... to Rapidly Penetrate the Market , AlphaHelix ... - AmpXpress(TM) - to meet demands for lower,instrument prices. This was ...
Cached Biology Technology:Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 2Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 3Genedata Screener Supports Small Molecule Research at the Broad Institute of Harvard and MIT 4Verenium Announces Proposed Public Offering of Common Stock 2Verenium Announces Proposed Public Offering of Common Stock 3AlphaHelix Presents AmpXpress(TM) at the BIOTECHNICA Show 2
...
... supplies, for 10 chips, provides the ... standard-sensitivity RNA analysis (nanogram levels) with ... electrophoresis system. Supplied are 1,250 microliters ... stain, 20 microliters RNA ladder, 900 ...
MAb to Verotoxin II (SLT-2a) Verotoxin II (Shiga-like) A subunit (SLT-2a)...
...
Biology Products: