Navigation Links
Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

For everyone doing or reading a paper about microarray-based experiments, reproductibility, especially inter-lab, is the #1 concern. Can I trust these results? If I redo the same experiment in one month, will I be able to compare both? The NIH recently demonstrated that microarrays experiments performed in different labs "have a high degree of reproducibility, as long as standardized protocols are carefully followed". Good news for the scientific community (and the microarrays producing companies)! A study funded by the National Cancer Institute, part of the National Institutes of Health, shows for the first time that microarray data generated in different laboratories can produce highly comparable results. For this comparison study, appearing in the Jan. 15, 2005, Clinical Cancer Research*, four separate laboratories analyzed gene expression (whether genes are turned on or off) for the same set of human tumor tissues. Overall, the expression profiles of portions of individual samples were highly comparable, and the experimental correlation between separate labs was only slightly lower than correlation of duplicated experiments within the same labs.

“This study is a key first step in moving gene expression data from small-scale bench science into large-scale clinical evaluation,?said James Jacobson, Ph.D., chief of NCI’s Diagnostic Biomarkers and Technology Branch. Gene expression microarrays have been used in numerous applications, including identifying novel genes associated with certain cancers, classifying tumors, and predicting patient outcome. So far, though, microarray studies have been performed by individual institutions. Evaluation of the potential clinical use of microarrays may require larger studies carried out in multiple locations and would neces
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Links Ebola Outbreaks To Animal Carcasses
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
7. Study finds more than one-third of human genome regulated by RNA
8. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
9. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
10. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
11. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
Post Your Comments:
(Date:7/10/2014)... New York , July 7, 2014 ... by Transparency Market Research "Electronic Access Control Systems Market ... 2014 - 2019," the global Electronic Access Control systems ... and is expected to grow at a CAGR of ... value of USD 31,187.8 million in 2019. ...
(Date:7/10/2014)... 2014  Acuity Market Intelligence today released forecasts from "The ... that the global market for National Electronic ID (eID) programs ... During this time, the number of National eID cards in ... Asia , with its vast population, will dominate ... issued, while Europe trails a distant ...
(Date:7/10/2014)... mainly tropical flowering plant family Melastomataceae (Meadow Beauty Family). Most ... bees for their pollination. Only about 100 are known to ... Axinaea appear in clusters of few to more ... are pink, yellow, orange or red. The stamens (male reproductive ... bulbous appendages. The pollination mechanism of Axinaea had ...
Breaking Biology News(10 mins):Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 2Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 3Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 4Electronic Access Control Systems Market is Expected to Reach USD 31.2 Billion Globally in 2019: Transparency Market Research 5National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2Novel type of bird pollination mechanism discovered in South America 2
... DC - New research suggests that monoclonal antibody therapy of ... it is today, says a researcher at Georgetown University Medical ... of the Lancet . "We believe that antibody ... Louis Weiner, MD, director of the cancer center at GUMC ...
... rigorous environmental cleaning intervention can reduce the transmission ... other multidrug-resistant organisms in hospital intensive care units ... at the annual meeting of the Society for ... that following an enhanced cleaning protocol reduced the ...
... of a new study into plant sex and discovered ... The study takes to a new level understanding of ... Professor David Twell and colleagues in the Department of ... a gene that has a critical role in allowing precursor ...
Cached Biology News:Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer 2Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer 3Environmental cleaning intervention reduces transmission of multidrug-resistant organisms in ICUs 2Plant biologists discover gene that switches on 'essence of male' 2
(Date:7/10/2014)... Ceres, Inc . (Nasdaq: CERE ), an ... for the three months ended May 31, 2014 and ... reported that the company and its customers have made ... Brazil, which concluded in June, despite dry and hot ... part of the growing season. Yields of several of ...
(Date:7/10/2014)... today in the journal PNAS (Proceedings of the ... of day and sleep deprivation have a significant effect ... looking at the best time of day to test ... for administering medicines effectively. , Researchers from the University ... investigated the links between sleep deprivation, body clock disruption ...
(Date:7/10/2014)... geckos and spiders can sit upside down forever. Nanophysics makes ... this in an article just published in Physical Review ... , Geckos and spiders that seem to be able to ... researchers worldwide for many years. We will soon be able ... as the gecko,s foot. But the fact is, sooner or ...
(Date:1/15/2014)... assembling a club sandwich at the nanoscale, National ... succeeded in crafting a uniform, multi-walled carbon-nanotube-based coating ... used in upholstered furniture and other soft furnishings. ... was reduced 35 percent compared with untreated foam. ...
Breaking Biology Technology:Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Time of day crucial to accurately test for diseases, new research finds 2Even geckos can lose their grip 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... June 6, 2011 At the White House today, ... the seven U.S. recipients of the 2010 Kavli Prizes ... three fields for which the Prizes are awarded -- ... http://photos.prnewswire.com/prnh/20110606/DC14848 ) Joined by the President,s science ...
... Inc., the recognized leader in microbiology, infectious disease ... transplant and biomedical sciences communities, today announced that ... of Strategic Development following two years with the ... Inc. client base significantly. In Ronholdt,s ...
... Biotech announced the sale of its leading ... probiotic dietary supplements to Schiff Nutrition International, Inc. ... receive royalties on Schiff products containing GanedenBC30 ™. ... Ganeden,s probiotic technology, GanedenBC30™, in the over-the-counter (OTC) and ...
Cached Biology Technology:President Obama Meets U.S. Laureates of 2010 Kavli Prizes 2President Obama Meets U.S. Laureates of 2010 Kavli Prizes 3LABS, Inc. Promotes Chad Ronholdt to VP of Strategic Development 2Ganeden Biotech Completes $40 Million Sale of Sustenex® and Digestive Advantage® Probiotic Brands 2Ganeden Biotech Completes $40 Million Sale of Sustenex® and Digestive Advantage® Probiotic Brands 3