Navigation Links
Study: Well-known protein helps stem cells become secretory cells

Johns Hopkins researchers have discovered that a single protein regulates secretion levels in the fruit fly's salivary gland and its skin-like outer layer.

Described in the May 15 issue of Development, the finding improves understanding of how cells become specialized for secretion, which is a critical ability of certain glands and cell types in organisms from insects to humans.

The researchers discovered that a protein called CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland and epidermis, its skin-like outer layer.

CrebA, or a closely related human gene, might play the same role in certain human cells, too, the researchers say.

In juvenile (type I) diabetes, for example, pancreatic cells that normally produce and secrete insulin don't work, and stem cells might be able to help fix that problem, the researchers note. "The key is knowing how pancreatic cells know what hormones to produce and release, or how any gland does, and the new findings add to that knowledge," says Deborah Andrew, Ph.D., professor of cell biology in Johns Hopkins' Institute for Basic Biomedical Sciences.

Curiosity brought Andrew and Elliott Abrams, then a graduate student, to focus on secretion in the salivary gland, the largest glandular organ in the fruit fly embryo, approximately six years ago. In humans and in fruit flies, the gland secretes saliva, a fluid containing water, mucus, electrolytes, and food-dissolving enzymes, into the mouth, and is important to the digestive system.

In their new experiments, the researchers looked at the expression of 34 secretory genes in a normal fruit fly embryo to see which genes were turned on when. All 34 genes were expressed at high levels in the early salivary gland, they found. According to Andrew, "This suggests the salivary gland becomes programmed for secretion because all the components required to allow secretion to occur are 'turned on'
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
2. Study: homemade gene expression technology unreliable
3. Study: Harmless virus kills some cancers
4. Study: Predatory dinosaurs had bird-like pulmonary system
5. Study: Plants use dual defense system to fight pathogens
6. Study: Competition for sex is a jungle out there
7. Study: Paramedics save more lives when they dont follow the rules
8. Study: Living coral reefs provide better protection from tsunami waves
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. New binding target for oncogenic viral protein
11. Controversial drug shown to act on brain protein to cut alcohol use
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Well known protein helps stem cells become secretory cells

(Date:7/30/2014)... Americans make better decisions about what they eat, the ... significant changes to the Nutrition Facts label found on ... in Chemical & Engineering News (C&EN), the ... the suggested updates and the fight that has ... points out that while the Nutrition Facts label has ...
(Date:7/30/2014)... awarded the Scientific Committee on Antarctic Research,s (SCAR) ... SCAR, an inter-disciplinary international science body, initiates, develops ... the Antarctic region, and on the role of ... organisation also provides scientific advice about Antarctica to ... region. , The medal is open internationally to ...
(Date:7/30/2014)... a multitude of cells types. Researchers would like to understand ... mature cells that make up the organs and other structures ... long chains of sugars that dangle from proteins on surfaces ... California, San Diego, has created synthetic molecules that can stand ... manipulated to direct the process, they report in the ...
Breaking Biology News(10 mins):
... is a well-known cause of cardiovascular disease, research from the ... revealed that the body,s obesity hormones adiponectin - are ... Our skeleton is more than just bones, vertebrae ... is constantly linked to our brain, our muscles and our ...
... LANSING, Mich. Discovering new treatments and battling dangerous ... researchers targeting the genetic disorder cystic fibrosis with projects ... research studies, with support from a $110,000 grant from ... and Translational Sciences Institute, expand the relationship between the ...
... 1st, 2011) Policy decisions and poor management have ... national security, according to an article available today in ... Scientists, published by SAGE. The article calls into question ... scientists for the decline. , According to George Mason ...
Cached Biology News:4 projects target cystic fibrosis with Hunt for a Cure funds 2Structure, not scientists to blame for Los Alamos failings 2Structure, not scientists to blame for Los Alamos failings 3
(Date:7/30/2014)...  Replikins Ltd. today released new data on changes ... the current outbreaks, the mean Ebola Reston gene Replikin ... 1995 and 2002 was 1.1; the mean Replikin Count ... in 2013, thus predicting the current outbreaks in humans. ... shown to be able to predict outbreaks (1).  For ...
(Date:7/30/2014)... 2014 With the accelerated aging ... health expenditure as well as the improved medical ... diagnostic reagent industry has been developing quickly, especially ... 2013, Chinese in vitro diagnostics market size reached ... in vitro diagnostic reagents. , Read complete ...
(Date:7/30/2014)... July 30, 2014  Orexigen Therapeutics, Inc. (Nasdaq: ... Day 180 List of Outstanding Issues (LOI) from the ... Use (CHMP) for the NB32 Marketing Authorization Application (MAA). ... an investigational drug candidate being evaluated for weight loss. ... 120 time point were adequately addressed by the Company ...
(Date:7/30/2014)... MARLBOROUGH, Mass. , July 30, 2014 ... RXII ), a biotechnology company focused on ... major unmet medical needs using RNA-targeted technologies, ... study (RXI-109-1402) with RXI-109, for the reduction ... scar revision surgery, has been initiated. ...
Breaking Biology Technology:China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 2RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 3RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 4RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars 5
... technology professionals often face the challenge of delivering ... maximize both storage and bandwidth efficiency, while providing ... announced SecureZip, a new family of products designed ... in a cross-platform environment. The company also introduced ...
... Sanyo have announced they will work together to produce ... ,Sanyo will be working with Rayovac's I-C3 technology, which the ... in 15 minutes. I-C3, or In-Cell Charge Control, is a ... regulates the charging mechanism, rather than allowing the charger free ...
... when entrepreneur Ken Schlager started a company, he looked ... This time around, Schlager is turning to the Center ... he launches a cutting-edge technology that applies electromagnetic fields ... has developed a process that oxidizes wastewater and removes ...
Cached Biology Technology:PKWare launches new enterprise product line, adds new features to PKZip 2PKWare launches new enterprise product line, adds new features to PKZip 3CTT - Bridging the states entrepreneurial gap 2CTT - Bridging the states entrepreneurial gap 3
... Development kit contains the basic components required ... measure natural and recombinant rat L-Selectin in ... kit contains sufficient materials to run ELISAs ... the following conditions are met: ...
RABBIT ANTI PORCINE CARBOXYPEPTIDASE B...
Recombinant Ovine (Sheep) Growth Hormone, Ultra Pure...
Request Info...
Biology Products: