Navigation Links
Study: Well-known protein helps stem cells become secretory cells

Johns Hopkins researchers have discovered that a single protein regulates secretion levels in the fruit fly's salivary gland and its skin-like outer layer.

Described in the May 15 issue of Development, the finding improves understanding of how cells become specialized for secretion, which is a critical ability of certain glands and cell types in organisms from insects to humans.

The researchers discovered that a protein called CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland and epidermis, its skin-like outer layer.

CrebA, or a closely related human gene, might play the same role in certain human cells, too, the researchers say.

In juvenile (type I) diabetes, for example, pancreatic cells that normally produce and secrete insulin don't work, and stem cells might be able to help fix that problem, the researchers note. "The key is knowing how pancreatic cells know what hormones to produce and release, or how any gland does, and the new findings add to that knowledge," says Deborah Andrew, Ph.D., professor of cell biology in Johns Hopkins' Institute for Basic Biomedical Sciences.

Curiosity brought Andrew and Elliott Abrams, then a graduate student, to focus on secretion in the salivary gland, the largest glandular organ in the fruit fly embryo, approximately six years ago. In humans and in fruit flies, the gland secretes saliva, a fluid containing water, mucus, electrolytes, and food-dissolving enzymes, into the mouth, and is important to the digestive system.

In their new experiments, the researchers looked at the expression of 34 secretory genes in a normal fruit fly embryo to see which genes were turned on when. All 34 genes were expressed at high levels in the early salivary gland, they found. According to Andrew, "This suggests the salivary gland becomes programmed for secretion because all the components required to allow secretion to occur are 'turned on'
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
2. Study: homemade gene expression technology unreliable
3. Study: Harmless virus kills some cancers
4. Study: Predatory dinosaurs had bird-like pulmonary system
5. Study: Plants use dual defense system to fight pathogens
6. Study: Competition for sex is a jungle out there
7. Study: Paramedics save more lives when they dont follow the rules
8. Study: Living coral reefs provide better protection from tsunami waves
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. New binding target for oncogenic viral protein
11. Controversial drug shown to act on brain protein to cut alcohol use
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Well known protein helps stem cells become secretory cells

(Date:11/4/2014)... University of Utah engineers developed the first room-temperature fuel ... electricity without needing to ignite the fuel. These new ... off-grid power and sensors. , A study of the ... Society journal ACS Catalysis . , Fuel cells ... a fuel and an oxygen-rich source such as air. ...
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... A newly published research study examining only marketing ... of fast food restaurants has found that the ... disproportionately exposed to such marketing tactics. , Authored ... her colleagues, the study is the first to ... interior and exterior of fast food restaurants and ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
... SomaLogic, Inc. and AmberGen, Inc. announced today ... agreement whereby AmberGen will provide its proprietary ... of SomaLogic,s SOMAscanTM technology platform. ... a high-throughput proteomic quantitation platform is achieving ...
... about it, a discovery by a Kansas State University ... for man,s best friend. University researchers Tonatiuh Melgarejo, ... professor of immunophysiology; and Yongming Sang and Maria Ortega, ... peptide that helps dogs to better fight pathogens -- ...
... Adelaide scientist says much more could be done to predict ... tuberculosis (TB) or foot-and-mouth disease - in Australian wildlife and ... have evaluated freely available software tools that provide a realistic ... used a combination of models to look at the possible ...
Cached Biology News:Going to the dogs: University's newest patent for improving canine health 2Going to the dogs: University's newest patent for improving canine health 3New thinking required on wildlife disease 2
(Date:11/26/2014)... , Nov. 26, 2014 The ... from a survey of European physicians at the ... Innovation and Biological Therapies" at the Spanish Ministry ... hosted by EuropaBio and the Spanish Bioindustry Association ... Health, physicians from Spanish oncology and rheumatology societies, ...
(Date:11/26/2014)... Charlotte, NC (PRWEB) November 25, 2014 ... High Intensity Focused Ultrasound (HIFU) devices, recently participated ... “ Small Renal Mass 360° .” Key opinion ... and therapeutic advances related to small renal masses ... learn about different ablative technologies in hands-on labs. ...
(Date:11/26/2014)... 25, 2014 Miles Holder, formerly of ... Graphel Carbon Products team as Sales/Marketing Manager. Mr. Holder ... customer service for the graphite industry. , “We are ... team,” stated Dave Trinkley, VP of Market and Product ... of experience in the graphite industry, along with his ...
(Date:11/26/2014)... Bio-Techne Corporation (NASDAQ: TECH ) announced today ... serve in a newly created position of Senior Vice ... be responsible for managing the operations of Bio-Techne,s Protein ... in July 2014 and the recently acquired CyVek business. ... ProteinSimple develops and commercializes proprietary systems and consumables that ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3
... N.J., Oct. 23 Collagen Matrix, Inc.,announces the ... orthopedic,and spine applications. OssiMend is an all-natural mineral-collagen,composite ... marrow,is used to fill bony voids or gaps ... OssiMend is conformable, non-friable, has a high,absorption capacity, ...
... Imaging Ltd.,(TASE, Nasdaq: EMITF) ("EMI" or the "Company") ... PLAZ) ("Plaza"), a leading Central and,Eastern European ("CEE") ... that it has entered into a joint venture ... office projects in,Romania. BAS is a private company ...
... data show preferential, activity of adecatumumab on inhibiting ... 169 patients treated with adecatumumab demonstrate an ... of immunogenicity of the antibody, BETHESDA, Md., Oct. 23 ... on the development of,novel, proprietary antibody-based products for the treatment ...
Cached Biology Technology:Collagen Matrix, Inc. Launches OssiMend(TM) Bone Graft Matrix for Orthopedic and Spine Applications 2Elbit Medical Imaging Ltd. Announces that Plaza Centers Has Entered into a Joint Venture Partnership to Develop Residential and Office Projects in Romania 2Elbit Medical Imaging Ltd. Announces that Plaza Centers Has Entered into a Joint Venture Partnership to Develop Residential and Office Projects in Romania 3Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 2Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 3Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 4Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings 5
... This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (E6152) or ... Comp Dim: H diam. 11.25 ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
...
...
Biology Products: