Navigation Links
Study: Well-known protein helps stem cells become secretory cells

Johns Hopkins researchers have discovered that a single protein regulates secretion levels in the fruit fly's salivary gland and its skin-like outer layer.

Described in the May 15 issue of Development, the finding improves understanding of how cells become specialized for secretion, which is a critical ability of certain glands and cell types in organisms from insects to humans.

The researchers discovered that a protein called CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland and epidermis, its skin-like outer layer.

CrebA, or a closely related human gene, might play the same role in certain human cells, too, the researchers say.

In juvenile (type I) diabetes, for example, pancreatic cells that normally produce and secrete insulin don't work, and stem cells might be able to help fix that problem, the researchers note. "The key is knowing how pancreatic cells know what hormones to produce and release, or how any gland does, and the new findings add to that knowledge," says Deborah Andrew, Ph.D., professor of cell biology in Johns Hopkins' Institute for Basic Biomedical Sciences.

Curiosity brought Andrew and Elliott Abrams, then a graduate student, to focus on secretion in the salivary gland, the largest glandular organ in the fruit fly embryo, approximately six years ago. In humans and in fruit flies, the gland secretes saliva, a fluid containing water, mucus, electrolytes, and food-dissolving enzymes, into the mouth, and is important to the digestive system.

In their new experiments, the researchers looked at the expression of 34 secretory genes in a normal fruit fly embryo to see which genes were turned on when. All 34 genes were expressed at high levels in the early salivary gland, they found. According to Andrew, "This suggests the salivary gland becomes programmed for secretion because all the components required to allow secretion to occur are 'turned on'
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
2. Study: homemade gene expression technology unreliable
3. Study: Harmless virus kills some cancers
4. Study: Predatory dinosaurs had bird-like pulmonary system
5. Study: Plants use dual defense system to fight pathogens
6. Study: Competition for sex is a jungle out there
7. Study: Paramedics save more lives when they dont follow the rules
8. Study: Living coral reefs provide better protection from tsunami waves
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. New binding target for oncogenic viral protein
11. Controversial drug shown to act on brain protein to cut alcohol use
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Well known protein helps stem cells become secretory cells

(Date:8/20/2014)... approximately 3 million infants, a team of scientists across ... Massachusetts Medical School, have shown that newborn screening for ... public health newborn screening programs. Data from 11 newborn ... the Journal of the American Medical Association ... newborns is higher than previously thought and believed to ...
(Date:8/20/2014)... suffered concussions ready to return to action? A new ... athletes who head back on the field with medical ... their abilities to simultaneously walk and do simple mental ... their balance and/or altered walking speed, was found in ... returned to activity in less than a month. Seven ...
(Date:8/20/2014)... bags could one day be made out of cocoa, ... now reporting. The novel process they developed and their ... agricultural and plastic waste problems, appear in the ACS ... Bayer and colleagues at the Italian Institute of Technology ... 2012, its production reached 288 million tons worldwide, but ...
Breaking Biology News(10 mins):Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... Disorder , (#1119044, Wednesday, October 26, 3:00 PM Eastern) , ... vary in intensity, may be an indicator of periodic limb ... PMLD, researchers from Toledo, Ohio divided the patients into those ... 84 right-handed and 16 left-handed patients, 69% of right-handed patients ...
... PA, October 24, 2011 Nutrition Facts labels have ... these labels read in detail by consumers when making ... labels? According to a new study published in the ... Dietetic Association, consumers, self-reported viewing of Nutrition Facts ...
... for Science and Technology is the first post-secondary school to ... Experiments . Though JoVE , the first and ... video articles showing basic experimental procedures, the majority of the ... -- not the level of research one would usually associate ...
Cached Biology News:CHEST 2011: Embargoed studies highlight new sleep disorder research 2CHEST 2011: Embargoed studies highlight new sleep disorder research 3Consumers don't pay as much attention to nutrition fact labels as they think 2Consumers don't pay as much attention to nutrition fact labels as they think 3
(Date:8/20/2014)... (PRWEB) August 20, 2014 High ... and apply the most complete climate and Earth ... demanding climate change issues. , Eight national laboratories, ... with the National Center for Atmospheric Research, four ... new effort. Other participating national laboratories include Argonne, ...
(Date:8/20/2014)... Not long ago, it was more or less ... in the development cycle – even after the final ... that, like many things GxP, expectations for early E&L ... drug sponsors have been required by authorities to provide ... I/II. It’s not only clinical trial material containers causing ...
(Date:8/20/2014)... August 20, 2014 GraphDB™ ... today including improvements to the enterprise replication cluster, ... for Lucene, SOLR and Elasticsearch. This release happens ... high performance triplestore – GraphDB™ was formerly known ... deploying the only mature enterprise resilient RDF triplestore ...
(Date:8/19/2014)... A Geisinger researcher on a personal crusade ... for Disease Control and Prevention (CDC) award recognizing his ... Joseph Boscarino , Ph.D. MPH, senior ... of researchers nominated for the Centers for Disease Control ... Data Methods and Study Design. "Hepatitis C ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... Madison, Wis. - Leslie Hearn's first rule for the ... ,While some techno jargon is unavoidable, the value of plain-spoken ... TDS Telecom . , , Leslie Hearn ... project," she said. "There has to be a lot of ...
... music consumers, the rights of artists are as often ... The studios appeal to consumers, saying that downloading without ... stifle creativity. , ,In the great food chain of ... creatures, paid pennies to the studios' dollars. , ,For ...
... Wis. - William R. Hendee will retire effective June ... at the Medical College of Wisconsin , and devote ... who also will retire as president of the MCW Research ... College conducts a national search for a permanent successor it ...
Cached Biology Technology:CIO Leadership Series: Leslie Hearn, TDS Telecom 2CIO Leadership Series: Leslie Hearn, TDS Telecom 3CIO Leadership Series: Leslie Hearn, TDS Telecom 4Going ga-ga over lala.com 2Medical College grad school dean Bill Hendee to retire 2
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
... The 1-D PAGE Cleavable ... for Targeted Protein ID ... PolyAcrylamide Gel Electrophoresis (PAGE), ... and cleavable-linker technology to ...
Supplemental reagent for annexin V assay....
Antibody Purification Specificity: Antibody Purification ...
Biology Products: