Navigation Links
Studies reveal methods viruses use to sidestep immune system

A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold.

In a study to appear in a March issue of the Journal of Virology and currently available online, UT Southwestern researchers describe how an essential gene, called RIG-I, turns on a cascade of host immune defenses when the hepatitis C virus (HCV) replicates in cultured human cells.

Those immune defenses should fight off the virus, but in a separate study, scheduled to appear online this week and in an upcoming issue of the Proceedings of the National Academy of Sciences, the researchers show how HCV sidesteps the immune response, allowing the virus to replicate unchecked.

Dr. Michael Gale, associate professor of microbiology at UT Southwestern and senior author of the two studies, said the tactics employed by HCV to infect a host are likely to be similar to those employed by other RNA viruses such as West Nile, influenza and the common cold.

"This work has broad implications that go beyond just the hepatitis C virus, and that's what we're most excited about," said Dr. Gale. "It's a battle between viruses and humans. Viruses have co-evolved with their hosts, so every time we have evolved a gene with a new function that allows us to fight off a virus, the virus adapts and comes up with a new function of its own to counteract our defenses."

Further defining how RNA viruses target and control host immune defenses will aid in drug development to combat disease, he said.

In the Virology paper, Dr. Gale and his research group found that a specific mutation in the gene RIG-I conferred permissiveness to HCV, allowing it to replicate "like gangbusters" in those cells with the mutation, Dr. Gale said. He and his group determined that the protein m
'"/>

Source:UT Southwestern


Page: 1 2 3

Related biology news :

1. Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
2. Studies clarify risk factors for mother-to-child transmission of hepatitis C virus
3. Studies on human genome variation provide insight into disease
4. Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
5. Studies find general mechanism of cellular aging
6. Studies look at how genes affect antipsychotic drug response
7. Studies yield insight into the numerical brain
8. Studies force new view on biology of flavonoids
9. Elusive HIV shape change revealed; Key clue to how virus infects cells
10. Timing is everything: First step in protein building revealed
11. Researchers reveal the infectious impact of salmon farms on wild salmon
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Studies reveal methods viruses use sidestep immune system

(Date:9/2/2014)... With their long, spiky legs and their propensity for ... stuff of nightmares. And now research from North Carolina ... spread into homes across the eastern United States. , ... or pose any kind of threat to humans," says ... State and lead author of a paper about the ...
(Date:9/1/2014)... An increasing amount of research shows an association between ... sedentary lifestyle. Now, a new Cornell University study points ... programs might lead people to eat twice as much ... an action movie while snacking your mouth will see ... on the new article just published in the ...
(Date:9/1/2014)... after birth, every child in the U.S. undergoes a ... conditions, including sickle cell disease. Thousands of children born ... many suffer and die from the disease each year. ... to at least some of those deaths. , ... in the lab of George Whitesides, the Woodford L. ...
Breaking Biology News(10 mins):Researchers find Asian camel crickets now common in US homes 2Can action movies make you fat? 2Faster, cheaper tests for sickle cell 2Faster, cheaper tests for sickle cell 3
... Who is related to whom, who begat whom, how did ... reptiles. In 2011, his fieldwork in Sri Lanka studying ... identity of 60 known species of snakes. With Sri Lankan ... amphibians and reptiles, and Dushantha Kandambi, a local naturalist and ...
... Copenhagen, Denmark, Shenzhen, China. Tue., 12 March 2013 ... world,s largest genomics organization, will be working together aiming ... genomics and bioinformatics capabilities of both institutions. This partnership ... food security, energy and health. , Prof Richard Cogdell, ...
... to have an ambiguous, obscure or hidden meaning. In ... are hidden inside their genes. Two University of ... tiny clams, long believed to be members of the ... along the rocky shores of southern Australia for millions ...
Cached Biology News:Sri Lankan snake study reveals new species, rich biodiversity in island country 2BGI and TGAC join efforts to tackle global challenges in food security, energy and health 2Cryptic clams: U-M biologists find species hiding in plain view 2Cryptic clams: U-M biologists find species hiding in plain view 3
(Date:9/2/2014)...  Technology Applications International Corporation (the "Company" or "NUUU")(OTC ... Int,l, Inc. has signed an additional exclusive licensing agreement ... the Johnson Space Center in Houston ... Charles J. Scimeca , ... our latest, exclusive agreement with NASA. In addition to ...
(Date:9/2/2014)... Orexigen Therapeutics, Inc. (Nasdaq: OREX ... Office (PTO) has issued a patent related to NB32, ... NB32 is a fixed-dose combination of naltrexone sustained release ... 8,815,889 claims methods for treating insulin resistance using a ... 2024. If NB32 is approved for use in ...
(Date:9/2/2014)... 2014  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... candidates targeting specific pathogens that cause serious infections ... final preclinical toxicology study of SYN-004. Per U.S. ... study was required to move the Company,s lead ... devastating effects of Clostridium difficile (C. difficile), ...
(Date:9/2/2014)... , Sept. 2, 2014  Spherix Incorporated (SPEX) -- an intellectual ... of intellectual property, today announced that the United States ... the Company in the month of August that are ... The issued patents are: ... issued August 19, 2014; and , U.S.RE45,095 issued ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 2Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 3Orexigen Expands NB32 Intellectual Property Portfolio With New U.S. Patent 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2
... AdvanceBio LLC, a Cincinnati-based advanced biofuel technology company, ... fuel ethanol process. The process is capable ... sugar beet and other similar crops as feedstock for ... generating zero liquid waste. When built in ...
... TIRAT CARMEL, Israel, August 31, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Aug. 30 Marrone Bio Innovations (MBI) ... for the control of invasive mussels, at the ... San Diego, California, August 29 to September 2, 2010. ... representing academia, industry, government agencies, NGOs and other stakeholders ...
Cached Biology Technology:Zero Discharge Sweet Sorghum Ethanol Process Development 2InSightec Treats First Prostate Cancer Patients in Clinical Trials 2InSightec Treats First Prostate Cancer Patients in Clinical Trials 3InSightec Treats First Prostate Cancer Patients in Clinical Trials 4InSightec Treats First Prostate Cancer Patients in Clinical Trials 5InSightec Treats First Prostate Cancer Patients in Clinical Trials 6InSightec Treats First Prostate Cancer Patients in Clinical Trials 7InSightec Treats First Prostate Cancer Patients in Clinical Trials 8Marrone Bio Innovations to Present Invasive Mussel Control Solution 2
Mouse monoclonal antibody raised against a partial recombinant SCARB2. NCBI Entrez Gene ID = SCARB2...
The F40 pump maintenance kit is used to service one F40 pump of a BioLogic DuoFlow workstation. It includes 2 piston seals, 4 check valves, seal removal tool, and 2 O-rings....
...
...
Biology Products: