Navigation Links
Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

ry specific weapons targeted at those individual pieces.

"This is a very clever system for this particular kind of bacteria," said Schneewind. It can take eight to 10 days for the B and T cells to multiply and fully engage. "By that time, with plague," he said, "the host is dead."

The bacteria's Achilles heel, however, may be a protein called LcrV, which Y. pestis transports through the needle and uses to inject its toxins. LcrV plays two roles. It helps the needle to penetrate the membrane surrounding the target cell. It also suppresses the immune response. LcrV causes affected cells to release 40 times the normal levels of interleukin 10 (IL-10), which dampens down the immune response. LcrV also prevents secretion of tumor necrosis factor (TNF), which causes inflammation.

"LcrV is secreted in massive amounts via the type-III pathway during an infection," Schneewind said. "Without it, the bacteria are relatively harmless."

Consequently, researchers have tried to use LcrV alone as a vaccine. Unfortunately, because it suppresses the immune system, immunization with this molecule may be harmful.

Schneewind and colleagues, however, tested 11 truncated versions of LcrV, snipping out, from different locales, 30 of the protein's 326 amino acids in hopes of eliminating the elements that suppressed the immune response but retaining enough of the normal protein's structure to generate protective antibodies.

Out of 11 altered versions they found one that met both criteria. In mouse and human macrophages, version rV10, missing amino acids 271 through 300, triggered only small amounts of IL-10 and had little effect on TNF secretion. Mice immunized twice over six weeks with rV10 developed antibodies that protected them from many times the lethal dose of the bacteria.

"Our data, the authors conclude, "provide the first evidence of plague vaccines that do not suppress innate immune responses ?and that may be useful for plague
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3 4

Related biology news :

1. Studies reveal methods viruses use to sidestep immune system
2. Studies clarify risk factors for mother-to-child transmission of hepatitis C virus
3. Studies on human genome variation provide insight into disease
4. Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
5. Studies find general mechanism of cellular aging
6. Studies look at how genes affect antipsychotic drug response
7. Studies yield insight into the numerical brain
8. Studies force new view on biology of flavonoids
9. Elusive HIV shape change revealed; Key clue to how virus infects cells
10. Timing is everything: First step in protein building revealed
11. Researchers reveal the infectious impact of salmon farms on wild salmon
Post Your Comments:
(Date:8/28/2015)... , August 28, 2015 ... and Training Market by Assessment Type (Pen & Paper ... Brain Training, Corporate Learning, Academic Research), Vertical and Region ... Assessment and Training Market to grow from USD 2.4 ... at a Compound Annual Growth Rate (CAGR) of 25.6% ...
(Date:8/20/2015)... , Aug. 20, 2015 The wearable ... that are active and healthy. However, wearable technology ... hospital environment to help improve diagnostic capabilities and ... from the Wearable Technologies Conference 2015 , ... applications for wearables in healthcare.    ...
(Date:8/18/2015)... Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ) ... Biometric Authentication & Identification Market: Focus On Modality, ... report to their offering. ... is expected to grow at an estimated CAGR ... over $25 billion (approximately) by 2020 as per ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... Zoo spend Father,s Day? He will spend it much like he ... and caring for his four chicks born April 20. This is ... hatched at the Zoo. "The birth of these chicks comes ... declining," said Zoo biologist Sara Hallager. "By developing a rhea studbook--an ...
... COLUMBIA, Mo. At noon, it was black as night. ... England thought judgment day was at hand. Accounts of that ... mentions of midday meals by candlelight, night birds coming out ... The mystery of this day has been solved by researchers ...
... Mass Media Fellows, Wendy Hansen and Maddalena Jackson, ... as part of a 10-week internship from June to ... respectively. Wendy Hansen is a biophysics Ph.D. ... a 2008 graduate of Harvey,Mudd College, Claremont, Calif., with ...
Cached Biology News:Mystery of infamous 'New England Dark Day' solved by 3 rings 2
(Date:9/2/2015)... , Sep. 02, 2015 ... announced the addition of Jain PharmaBiotech,s new report ... to their offering. This report follows ... characteristic that can be objectively measured and evaluated ... processes as well as pharmacological responses to a ...
(Date:9/2/2015)... , Sept. 2, 2015  Neurotech Pharmaceuticals, Inc., ... in the multicenter Phase 2 clinical trial of ... treatment of recurrent subfoveal choroidal neovascularization secondary to ... a unique vascular endothelial growth factor (VEGF) receptor ... "This landmark proof-of-concept study will evaluate ...
(Date:9/2/2015)... , September 2, 2015 BiondVax ... of the National Institute of Allergy and Infectious Diseases (NIAID), ... the Department of Health and Human Services (HHS), to launch ... the United States in the 2015-16 timeframe. ... vaccine candidate, Multimeric-001 (M-001), as a primer vaccine, which would ...
(Date:9/2/2015)... ... September 02, 2015 , ... The ... creating professional commercial video content, to analysis of athletic performance. Producing high-resolution ... go by too quickly to process with the naked eye. , Slow ...
Breaking Biology Technology:Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 2Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 3Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 4BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3
... Reston, Va. The American Institute of Aeronautics ... of Propulsion Science , that compiles for the first ... as space drives, warp drives, gravity control, and faster-than-light ... voyages to other star systems. , While the ...
... deCODE genetics,(Nasdaq: DCGN ) announced that on ... Listing Qualifications Panel (the "Panel") stating that the Panel,will ... Nasdaq Global,Market to the Nasdaq Capital Market, effective at ... 2009. The Nasdaq Capital Market, which is,one of the ...
... 3 Uroplasty, Inc. (Amex: UPI ),a ... products to treat voiding dysfunctions, today reported financial,results for ... 2008. Net,sales for the third quarter of fiscal ... year,s third quarter. , "As ...
Cached Biology Technology:New book from AIAA explores space drives, warp drives 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 3Uroplasty Reports Third Quarter Fiscal 2009 Results 2Uroplasty Reports Third Quarter Fiscal 2009 Results 3Uroplasty Reports Third Quarter Fiscal 2009 Results 4Uroplasty Reports Third Quarter Fiscal 2009 Results 5Uroplasty Reports Third Quarter Fiscal 2009 Results 6Uroplasty Reports Third Quarter Fiscal 2009 Results 7Uroplasty Reports Third Quarter Fiscal 2009 Results 8Uroplasty Reports Third Quarter Fiscal 2009 Results 9Uroplasty Reports Third Quarter Fiscal 2009 Results 10Uroplasty Reports Third Quarter Fiscal 2009 Results 11
... a fully automated microplate based multi-detection ... in academia and industry. The FLUOstar ... Fluorescence Intensity including FRET and ... including DELFIATM High-Performance Luminescence (flash ...
... can operate as a Voltage Clamp, as a ... in electrophysiology research applications. Performance in any one ... • This amazing instrument ... the capabilities of Digital Signal Processing (DSP) integrated ...
... activity is expressed in g per ml and ... saline, pH 6.8, of a 1 mg per ... lowest concentration to agglutinate a 2% suspension of ... incubation at 25 C. Preparation Note: ...
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Open-slot design for easy cleaning. ...
Biology Products: