Navigation Links
Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

Two studies by researchers at the University of Chicago show how the bacteria that cause the plague manage to outsmart the immune system and how, by slightly altering one of the microbe's tools, the researchers produced what may be the first safe and effective vaccine.

Both papers -- one published online July 28 in Science Express and one in the August issue of Infection and Immunity -- focus on aspects of the type-III pathway, a molecular syringe that Yersinia pestis, the bacterium that may have killed more people throughout history than any other infectious disease, uses to disable its host's immune system.

"Yersinia pestis is the nastiest thing alive," said study author Olaf Schneewind, M.D., Ph.D., professor and chairman of microbiology at the University of Chicago and director of the Great Lakes Regional Center of Excellence in Biodefense and Emerging Infectious Diseases Research (GLRCE). "It's the most virulent bacterial organism known to mankind. But we now know a little more about how it exercises those powers and we think we can use that knowledge to prepare a preemptive strike."

Historically, the terms "plague" or "Black Death" have referred to the bubonic plague, caused by Yersinia pestis and spread by the bites of infected fleas, which acquire the germ from infected rodents. In the mid-14th century, the plague swept through Europe killing nearly one-third of the population. It returned with a slightly reduced death count about once a generation for centuries.

Although far less common now, the plague has not entirely gone away. There are fewer than 2,000 cases a year worldwide, including 10 to 20 each year in the western United States. One out of seven persons infected dies, even with aggressive treatment.

Since 2001, however, many people have worried that terrorists could exploit Y. pestis as a weapon, spreading it widely and rapidly as an aerosol rather than through fleabites and rodents. Contracted this way -- inf
'"/>

Source:University of Chicago Medical Center


Page: 1 2 3 4

Related biology news :

1. Studies reveal methods viruses use to sidestep immune system
2. Studies clarify risk factors for mother-to-child transmission of hepatitis C virus
3. Studies on human genome variation provide insight into disease
4. Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
5. Studies find general mechanism of cellular aging
6. Studies look at how genes affect antipsychotic drug response
7. Studies yield insight into the numerical brain
8. Studies force new view on biology of flavonoids
9. Elusive HIV shape change revealed; Key clue to how virus infects cells
10. Timing is everything: First step in protein building revealed
11. Researchers reveal the infectious impact of salmon farms on wild salmon
Post Your Comments:
(Date:4/23/2014)... is a newly coined term for novels and films which ... University of Copenhagen shows how these fictions serve as a ... of climate change and imagine other living conditions. , ... in the atmosphere; it is also a cultural phenomenon in ... and the films we see. And there are so many ...
(Date:4/23/2014)... disease is the first cause of dementia and affects ... cure has yet been found. One of the reasons ... cellular mechanisms which cause alterations in nerve transmissions and ... the disease., Researchers from the Institute of Neuroscience at ... mechanism involved in memory consolidation and were able to ...
(Date:4/23/2014)... social mammals, ravens form different types of social relationships ... they also form strict dominance relations. From a cognitive ... key ability in daily social life ("knowing who is ... members have with each other sets the stage for ... of this study have been published in the scientific ...
Breaking Biology News(10 mins):Fiction prepares us for a world changed by global warming 2Fiction prepares us for a world changed by global warming 3Loss of memory in Alzheimer's mice models reversed through gene therapy 2Ravens understand the relations among others 2
... sleuthing system they developed to probe how cells manage ... common but hard-to-see sugar switches are partly in control. ... abundant and potential targets of manipulation by drugs, the ... for a number of diseases, including cancer, the scientists ...
... , REDWOOD CITY, Calif. , ... has selected DigitalPersona, Inc., a leader in fingerprint identity and ... Justice Information System (CJIS) mandates. Located in Central Florida , ... who serve more than 28,000 residents. The City chose DigitalPersona ® ...
... 2010 The Translational Genomics Research Institute (TGen) today ... agreement with the Van Andel Research Institute (VARI) that ... TGen expects the agreement to create a ... and treatments for patient benefit. ...
Cached Biology News:Sweet! -- sugar plays key role in cell division 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 3City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 4TGen finalizes alliance with Van Andel Research Institute 2TGen finalizes alliance with Van Andel Research Institute 3
(Date:1/15/2014)... 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today ... R-Pharm, a leading Russian pharmaceutical company, to develop and ... Russian Federation , Turkey ... is a novel antibiotic for the treatment of bacterial ...
(Date:1/14/2014)... Washington, DC (PRWEB) January 14, 2014 ... session for Thursday, January 23, 2014 at 2pm EST ... Actionable Knowledge.” The topic focuses on how technology can ... mission critical decisions for government agencies. The online webinar ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Copper,s days are numbered, and a new study ... the ubiquitous metal in smart phones, tablet computers, and ... who are seeking smaller, faster devices. As ... size, so do the copper pathways that transport electricity ...
... Interleukin Genetics, Inc. (OTCQB: ILIU) today announced financial and ... Total revenue for the three months ended September ... period in the prior year. The increase was attributable to ... expenses were $325,000 for the three months ended September 30, ...
... Nov. 10, 2011 GeoVax Labs, Inc. (OTCQB/OTCBB: GOVX), ... prevent and fight Human Immunodeficiency Virus (HIV) infections, today ... September 30, 2011. GeoVax reported a net ... months ended September 30, 2011, compared to $644,666 ($0.04 ...
Cached Biology Technology:Researching graphene nanoelectronics for a post-silicon world 2Researching graphene nanoelectronics for a post-silicon world 3Interleukin Genetics Reports Third Quarter 2011 Financial Results 2Interleukin Genetics Reports Third Quarter 2011 Financial Results 3Interleukin Genetics Reports Third Quarter 2011 Financial Results 4GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 2GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 3GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 4GeoVax Labs, Inc. Announces Nine Month 2011 Financial Results 5
... a variety of motion options - roller, ... unit. Shake, rock, roll and rotate motions!,, ... hybridization and blotting procedures requiring different settings, ... chamber uses a roller action to operate ...
... Magnetic Stand-96 is designed for paramagnetic bead ... 0.2 ml PCR plates with no additional ... base in a standard SBS 96-well microplate ... permanent magnets guarantees easy and fast (as ...
... magnetic particle based purification systems provide high ... any sample. They offer increased throughput and ... systems- KingFisher, KingFisher mL and KingFisher 96, ... l. Each system consists of an instrument, ...
... no-frills, basic SpeedVac concentrator designed for the ... unit still features a standard Teflon coated ... time and heat. It is designed for ... wide variety of different rotors for maximum ...
Biology Products: