Navigation Links
Studies on human genome variation provide insight into disease

ant hereditary component to the disease, and one of the most strongly associated genomic regions lies on the X chromosome.

This X chromosomal region spans a cluster of five SPANX genes that are predominantly expressed in the testis and in certain tumors. In this month's issue of Genome Research, Dr. Vladimir Larionov and his colleagues examined the genetic architecture of the SPANX cluster and showed how the region exhibited dynamic deletions, duplications, and gene conversion events, some of which may have resulted in the development of mutations involved in prostate cancer susceptibility.

"Because of the strong similarity among genes in this region, we had to develop a new technique for our mutational analysis, which we call TAR cloning," explains Larionov. "Using this method, we isolated the SPANX region from 200 individuals by recombination in yeast."

Based on their results, the authors speculate that predisposition to prostate cancer ?at least in some individuals ?is determined by the specific architecture of the SPANX gene cluster on the X chromosome. "We're hoping to clarify which specific types of genomic rearrangements lead to prostate cancer susceptibility," says Larinov, "so that we can someday identify therapeutic targets for this disease."

Contact:
Vladimir Larionov, Ph.D.
Head, Genome Structure and Function Section, National Cancer Institute
Phone: 301-496-7941
E-mail: larionov@mail.nih.gov

Genetic traffic in DiGeorge syndrome

One of the most common human genomic disorders, DiGeorge syndrome, occurs in one of every 2,000-4,000 live births and involves a deletion on chromosome 22. The deletion is mediated by rare repetitive sequences that flank genes crucial for proper development of the heart, face, and upper thorax.

Dr. Bernice Morrow and her colleagues describe in this month'
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2 3 4

Related biology news :

1. Studies reveal methods viruses use to sidestep immune system
2. Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
3. Studies clarify risk factors for mother-to-child transmission of hepatitis C virus
4. Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
5. Studies find general mechanism of cellular aging
6. Studies look at how genes affect antipsychotic drug response
7. Studies yield insight into the numerical brain
8. Studies force new view on biology of flavonoids
9. Novel technology detects human DNA mutations
10. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
11. UWs Rosetta software to unlock secrets of many human proteins
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Studies human genome variation provide insight into disease

(Date:12/10/2014)...  Valencell, a leader in performance biometric data sensor ... from its licensees for highly accurate, clinically validated biometric ... coming from fitness and health sectors, but first responders/military ... is only as useful as the biometric data it ... in long-term mass consumer adoption of wearable products," said ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
(Date:12/5/2014)... 2014  Tute Genomics, a leader in cloud-based solutions ... A1 funding led by UK-based Eurovestech. Peak Ventures and ... investment round. "We are at a pivotal ... sequencing and seeks new approaches for the diagnosis, treatment ... MD MBA, and CEO of Tute Genomics. "One of ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... marine sediments hold clues about Arctic climate variation during ... on reconstructions of Arctic climate variability in the greenhouse ... that man-made global warming probably would not greatly change ... climate variability such as the El Nio ...
... This release is available in German . ... to establish nine new Research Units. This decision was taken ... The new groups are intended to provide researchers with the ... and to develop new research strategies. Like all ...
... 11, 2011 -- The daughters of rats who took folic ... breast cancer rates twice as high as other rats, according ... developed them at a faster rate, according to the study ... Hospital in Toronto. Kim stressed more research needs to be ...
Cached Biology News:Arctic climate variation under ancient greenhouse conditions 2Arctic climate variation under ancient greenhouse conditions 3DFG establishes 9 new research units 2DFG establishes 9 new research units 3DFG establishes 9 new research units 4DFG establishes 9 new research units 5DFG establishes 9 new research units 6DFG establishes 9 new research units 7Offspring of female rats given folic acid supplements develop more breast cancer 2
(Date:12/22/2014)... Calif. , Dec. 22, 2014  ( www.competitivehealth.com ... CoPatient, an online medical bill review and advocacy service, ... in the FREE WellCard Savings discount health services marketplace. ... bill that was more than they expected to pay. ... reduce health care costs, WellCard Savings is pleased to ...
(Date:12/22/2014)... 2014 Fertility Associates of Memphis has ... USA , a network of more than 20 contributing ... patients have fast access to a national pool of ... . Fertility Associates of Memphis is the only fertility ... option. , Dr. William Kutteh , director of ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one of the nation’s ... Pharm.D. to the newly created position of Vice President ... Dr. Maroulis will continue to manage the entire specialty ... pharmacies as the company expands. Dr. Maroulis has been ... has served in many different capacities in the pharmacy, ...
(Date:12/19/2014)... REDWOOD CITY, Calif. , Dec. 19, 2014 ... , USA) announced today that they have been ... Technologies 1,2 is a privately held company that ... processing of next generation sequencing (NGS) data for the ... into the Roche Sequencing Unit, and will continue to ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Germany, April 17 Occlutech GmbH, the leading,European manufacturer ... recent news release., In a news release dated ... from AIPPI the European "Association for the Protection,of Intellectual ... European IP held by AGA Medical., AIPPI has ...
... Promise, MONTREAL, April 17 /PRNewswire-FirstCall/ - ProMetic ... compounds in preclinical,studies for prostate and pancreatic cancer ... Meeting 2008 being held in San Diego this,week., ... presented in poster,sessions as follows:, Dr. Mouna ...
... world,s leading,online bioscience job board community and life ... IBC Life Sciences whereby BioSpace will,produce a Life ... Discovery,& Development of Innovative Therapeutics World Congress (DDT) ... will be marketed and promoted to the 500,000 ...
Cached Biology Technology:Occlutech Clarifies Statement Regarding Favourable Opinion Obtained From AIPPI With Regard to Patents Held by AGA Medical 2ProMetic presents preclinical data for prostate and pancreatic cancer at the AACR Meeting 2ProMetic presents preclinical data for prostate and pancreatic cancer at the AACR Meeting 3BioSpace and IBC Life Sciences Announce Career Fair Alliance For Drug Discovery & Development of Innovative Therapeutics World Congress 2BioSpace and IBC Life Sciences Announce Career Fair Alliance For Drug Discovery & Development of Innovative Therapeutics World Congress 3
... Labeling Kit with CyScribe GFX Purification ... and purification of Cy3- and Cy5-labeled ... complete cDNA labeling and purification.Flexible and ... performing labeling reactions with either Cy3- ...
... CyScribe Post-Labeling Kit with CyScribe GFX ... generation and purification of Cy3- and ... for complete cDNA labeling and purification.Flexible ... for performing labeling reactions with either ...
Collected from sexually mature, mixed sex, mixed breed dogs. Serum from specific breeds available by request....
UV-NIR light source for USB2000, HR4000, HR2000+...
Biology Products: