Navigation Links
Studies look at how genes affect antipsychotic drug response

Researchers at the University of Illinois at Chicago College of Pharmacy are attempting to discover how genes determine how well an antipsychotic medication works in adults and children and the side effects it will cause.

Risperidone, a popular "atypical" antipsychotic medication, is used to treat mental illnesses such as schizophrenia and bipolar disorder.

Jeffrey Bishop, assistant professor of pharmacy practice, is examining the effects of one gene, catechol-o-methyltransferase, on brain activity, cognition and symptom response to the drug.

The study is being done in adults who are experiencing their first episode of schizophrenia who are treated with risperidone for six weeks as part of UIC's First Episode Program.

"Allowing patients with schizophrenia an increased chance at medication response literally could change their lives," Bishop said.

"While we know a great deal about the pharmacology of antipsychotics like risperidone, there is still much to learn about their influence on cognition and brain function, as well as how genetics affect overall medication response," he said.

Bishop says the project will serve as a first step toward a comprehensive pharmacogenetic analysis of metabolic pathways affecting response to the drug. He was presented with an award for new investigators from the American College of Clinical Pharmacy for the project.

The UIC Center for Cognitive Medicine's First Episode Program, directed by Dr. John Sweeney, has been studying patients with first-episode schizophrenia for the past five years.

Bishop is also beginning a second project to study how risperidone may elevate prolactin levels and cause weight gain in children ages 8-18 who suffer from pediatric bipolar disorder. An increase in prolactin (a pituitary hormone that may affect bone development) or weight gain occurs in some but not all of these young patients.

"We are trying to determine if some kids
'"/>

Source:University of Illinois at Chicago


Page: 1 2

Related biology news :

1. Studies reveal methods viruses use to sidestep immune system
2. Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
3. Studies clarify risk factors for mother-to-child transmission of hepatitis C virus
4. Studies on human genome variation provide insight into disease
5. Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
6. Studies find general mechanism of cellular aging
7. Studies yield insight into the numerical brain
8. Studies force new view on biology of flavonoids
9. Newly-discovered class of genes determines ?and restricts ?stem cell fate
10. Inexpensive, mass-produced genes core of synthetic biology advances at UH
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Studies look how genes affect antipsychotic drug response

(Date:8/21/2014)... in past decade, GTA still violates Canada,s ozone ... the Greater Toronto Area (GTA) has significantly reduced ... the city continues to violate the Canada-wide standards ... or aggravate health problems such as asthma, emphysema ... of complex photochemical reactions involving volatile organic compounds ...
(Date:8/21/2014)... growing in near darkness use a previously unknown process ... research team led by a Penn State University scientist ... research aimed at improving plant growth, harvesting energy from ... occurring on Lake Erie and other lakes worldwide. A ... Science Express edition of the journal ...
(Date:8/21/2014)... 21, 2014 /PRNewswire-iReach/ -- LiveScan Service Provider  ... to a partnership with Gabriel Health Institute, one ... growing Certified Nursing Assistant preparatory schools. The ... exclusive member of Binary,s LiveScan service provider,s owner/operator ... improve its service capabilities by widening the ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3
... 22, 2010 -- What can scientists learn from watching ... reading, and happily making new friends? Quite a lot, ... carefully observed this sort of group in a fatigue ... in The Journal of the Acoustical Society of America. ...
... team of researchers led by Carnegie Mellon University,s Manojkumar ... recycle, a critical piece in understanding signaling receptor function. ... first time describes how a signaling receptor travels back ... and internalized. Signaling receptors live on the cell ...
... Researchers at Cleveland Clinic,s Genomic Medicine Institute have revealed multiple ... for Cowden syndrome patients who are predisposed to breast and ... earlier discovery of cancerous tumors, is published in the Dec. ... Association ( JAMA ). Charis Eng, M.D., ...
Cached Biology News:Measuring fatigue through the voice 2Carnegie Mellon researchers discover mechanism for signaling receptor recycling 2Carnegie Mellon researchers discover mechanism for signaling receptor recycling 3Researchers discover genetic predisposition for breast, kidney cancers 2
(Date:8/21/2014)... The College of New Rochelle announced today ... Mid-Hudson Region to be designated as a START-UP NY ... qualified “high-technology” businesses that align with the College’s academic ... been selected for the START-UP NY program and extremely ... economic development in New York by growing business and ...
(Date:8/21/2014)... Calif. , Aug. 21, 2014  Four-dimensional ... and behaviors based on external stimuli such as ... to have a disruptive effect in multiple industries.  ... the business landscape by printing objects ranging from ... and automotive sectors. Logo - ...
(Date:8/21/2014)... On Wednesday of last week RENU 28, the world's ... became available for purchase in Australia and New Zealand, and ... 28 works is, if you think about the definition of ... cellular renewal within your body. If you think about the ... cellular renewal. What RENU 28 does is it works with ...
(Date:8/20/2014)... PLANTATION, Fla. , Aug. 20, 2014 /PRNewswire/ ... it will host a conference call to provide ... 26, 2014Time:4:30 p.m. Eastern daylight timeDial-in numbers:(888) 505-4369 ... number: 9126599 Live web cast: www.neurotropebioscience.com , under ... three hours after completion through September 2, 2014 ...
Breaking Biology Technology:The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Neurotrope To Host Conference Call 2
... Diagnostics (NYSE: DGX ), the world,s leading ... that the U.S. Food and Drug Administration (FDA) has ... its STRATIFY JCV ™ Antibody ELISA testing service. ... FDA market authorized for the qualitative detection of antibodies ...
... have new hope in a novel technology now offered ... Case Medical Center.  A team of cancer specialists, led ... the nation to launch a dedicated program using Hyperthermic ... other cancers. Performed immediately following surgery, HIPEC ...
... Calif., Jan. 20, 2012  Genomic Health, Inc. (Nasdaq: ... first clinical decision making study of the Onco type ... Score® (RS) result has a significant impact on treatment ... to be presented at the 2012 Gastrointestinal (GI) Cancers ...
Cached Biology Technology:Quest Diagnostics STRATIFY JCV™ First FDA Market Authorized Antibody-based Blood Test to Help Stratify PML Risk in Multiple Sclerosis Patients 2Quest Diagnostics STRATIFY JCV™ First FDA Market Authorized Antibody-based Blood Test to Help Stratify PML Risk in Multiple Sclerosis Patients 3UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients 2UH Case Medical Center Offers New Therapy for Gynecologic Cancer Patients 3Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium 2Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium 3Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium 4Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium 5Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium 6
... Immunogen: Peptide ... encompassing the human, mouse, and ... Accession Number: NM_000314 ... Routinely evaluated by immunoblot. ...
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
CCNI Antibody...
...
Biology Products: