Navigation Links
Students invent protective pouch to enhance cell therapy

Johns Hopkins undergraduates have invented a device to improve cell therapy for diabetes patients by anchoring transplanted insulin-producing cells inside a major blood vessel.

A team of five seniors and two freshmen, working with Johns Hopkins doctors and engineers, devised a protective "pouch" that should fit inside the portal vein, which feeds into the liver. This pouch would keep microcapsules of therapeutic cells in one place, allowing them to thrive and send out needed insulin. The inventors say the same approach could be used in cell therapy for other ailments, including liver disease.

"I think it's a brilliant idea," said one of the project's sponsors, Jeff W. M. Bulte, director of the Cellular Imaging Section in the Johns Hopkins Institute for Cell Engineering.

The pouch is formed by sandwiching a porous band of nylon mesh between two concentric metal stents, similar to the ones used to keep clogged blood vessels open. Once the stents are in place, microcapsules filled with helpful cells are injected into the gap between the stents, where they become trapped within the nylon mesh. Blood flowing through the vessel should nourish the encapsulated cells and circulate the proteins, such as insulin, produced by these cells.

The project is important because it could lead to better results from cellular therapy, in which live cells are injected to repair or replace damaged or depleted tissue. "It’s a device," Bulte said, "that allows the microcapsules to be removed and reinserted if additional therapy is needed ?a ‘yearly refill,?for example ?and the students have provided an ideal environment in which the encapsulated cells can thrive."

Along with other undergraduate projects, this prototype was unveiled May 2 at the university’s Biomedical Engineering Design Day showcase. The Johns Hopkins Technology Transfer staff has applied for a provisional patent. Animal testing is expected to begin this summer. If it is succ
'"/>

Source:Johns Hopkins University


Page: 1 2 3 4

Related biology news :

1. Students discover 11,000 year old remains of Irish Elk
2. Wright bros. upstaged! Dinos invented biplanes
3. Eminent inventor of DNA fingerprinting gains new recognition
4. U of M researchers invent flashy new process to turn soy oil, glucose into hydrogen
5. Cancer-killing invention also harvests stem cells
6. Natural vitamin E tocotrienol reaches blood at protective levels
7. UC Davis researchers reveal apples protective ways
8. Gladstone investigators identify a new protective action for the powerful anti-HIV factor, APOBEC3G
9. Canadian study shows bilingualism has protective effect in delaying onset of dementia by four years
10. Amino acids in nectar enhance butterfly fecundity: A long awaited link
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Students invent protective pouch enhance cell therapy

(Date:9/2/2014)... limestone is well known as a result of ... (for example, Archaeopteryx). Now, for the first time, ... equivalent of these outcrops - discoveries which include ... treader. , Despite the abundance of fossils in ... obtained from the Late Kimmeridgian equivalents of these ...
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
(Date:9/1/2014)... EDT) It may be possible to train the ... foods, according to new research by scientists at the ... (USDA HNRCA) at Tufts University and at Massachusetts General ... & Diabetes , a brain scan study in adult ... reverse the addictive power of unhealthy food while also ...
Breaking Biology News(10 mins):Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3Training your brain to prefer healthy foods 2
... inbreeding is a threat against the viabi lity of ... in the new journal PLoS ONE now demonstrates that ... expected. The results show that it is the most ... breeding population. An important consequence of this action of ...
... has discovered that some stealthy mammals have been doing something ... water. , The results of the research by Vanderbilt's Kenneth ... the science journal Nature. He became curious when he observed ... bubbles while swimming. , "This came as a ...
... which can become less effective over time, might retain ... second drug, according to new research in mice conducted ... of the National Institutes of Health, and their partners. ... of Cancer Cell*. , Tamoxifen has been used successfully ...
Cached Biology News:Wolves are suffering less from inbreeding than expected 2Contrary to common wisdom, scientist discovers some mammals can smell objects under water 2Contrary to common wisdom, scientist discovers some mammals can smell objects under water 3Restoring tamoxifen sensitivity in resistant breast cancer cells 2
(Date:9/2/2014)... , Sept. 2, 2014  Technology Applications International ... that its wholly-owned subsidiary Renuell Int,l, Inc. has signed ... and Space Administration ("NASA") at the Johnson Space Center ... See photos: tapplic.com/houstonphotos/ ... are very pleased to announce our latest, exclusive agreement ...
(Date:9/2/2014)... 2, 2014  Xencor, Inc. (NASDAQ: ... monoclonal antibodies for the treatment of autoimmune diseases, ... the appointment of Debra Zack , M.D., ... of Lloyd Rowland , senior vice president, ... "Debra,s expertise in biologics clinical development and ...
(Date:9/2/2014)... and Rocky Mount, NC (PRWEB) September 02, 2014 ... today the establishment of its 11th clinical research site: ... Research has assumed ownership and operation of the clinical ... Mount, NC, further expanding PMG’s presence in eastern North ... additional 130,000 patients. For the patients in Rocky Mount ...
(Date:9/1/2014)... NEW YORK , Sept. 1, 2014 /PRNewswire/ ... report is available in its catalogue: ... Opportunities, 2019 http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html ... municipal corporations are the main governing bodies responsible ... management in cities. On an average, around 135,000 ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 2Xencor Appoints Debra Zack, M.D., Ph.D., Vice President, Clinical Development and Lloyd Rowland, Senior Vice President, Chief Compliance Officer and General Counsel 3PMG Research Announces the Formation of its Eleventh Site 2PMG Research Announces the Formation of its Eleventh Site 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8
... today announced positive results from its Phase IIa ... severely injured trauma patients with hemorrhagic shock causing ... given in addition to standard of care, was ... During hemorrhagic shock, inadequate perfusion of critical organs ...
... 31 Naurex Inc., a clinical stage company developing ... reported that its clinical stage candidate for the treatment ... been selected for inclusion on Windhover,s list of the ... were chosen by a committee that included Windhover Information, ...
... SEATTLE, Aug. 31 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ... of Julie M. Eastland as Chief Financial Officer ... 2010. Ms. Eastland,s responsibilities will include financial management, ... Eastland brings more than 25 years of financial ...
Cached Biology Technology:Sangart, Inc. Reports Positive Phase IIa Data for Novel Oxygen Therapeutic Agent MP4OX in Severe Trauma Patients 2Sangart, Inc. Reports Positive Phase IIa Data for Novel Oxygen Therapeutic Agent MP4OX in Severe Trauma Patients 3Naurex's Novel Antidepressant GLYX-13 Recognized as One of Windhover's Top 10 Neuroscience Projects to Watch 2Naurex's Novel Antidepressant GLYX-13 Recognized as One of Windhover's Top 10 Neuroscience Projects to Watch 3Naurex's Novel Antidepressant GLYX-13 Recognized as One of Windhover's Top 10 Neuroscience Projects to Watch 4Naurex's Novel Antidepressant GLYX-13 Recognized as One of Windhover's Top 10 Neuroscience Projects to Watch 5ONCOTHYREON APPOINTS JULIE M. EASTLAND AS CHIEF FINANCIAL OFFICER 2
Taq DNA polymerase, 10,000U...
... AmpliTaq DNA Polymerase is the ... PCR process, a testimony to its overall ... profile makes it ideal for PCR applications. ... guarantee reproducible results. ,, AmpliTaq DNA ...
Taq DNA Polymerase (T. aquaticus), 4 x 250 units. For PCR and other procedures requiring DNA polymerase activity at elevated temperatures. Category: Nucleotides & Enzymes & Biochemicals, Modifying En...
... GCpro Taq DNA Polymerase is a versatile ... for all PCR applications. GCpro Taq DNA ... expressed in E. coli, containing the DNA ... enzyme includes a highly processive 5'-3' DNA ...
Biology Products: