Navigation Links
Stroke treatment a step closer after trial

A potential new treatment for stroke has taken a major step forward following promising results from the first clinical trial.

Researchers at The University of Manchester have shown in laboratory studies that a naturally occurring protein called IL-1ra protects brain cells from injury and death.

The team, led by Professor Nancy Rothwell and Dr Pippa Tyrrell, have now reported the results of the first small trial of IL-1ra in patients, which are published in the Journal of Neurology and Neuropsychiatry.

"The study was designed to test if IL-1ra is safe in stroke patients and showed promising results," said Professor Rothwell, a world-renowned neuroscientist based in the University's Faculty of Life Sciences.

"The trial was a definite step in the right direction and may lead to a full trial to test its effectiveness next year."

Stroke is the UK's third biggest killer and the biggest cause of disability, affecting 100,000 people each year. It accounts for 6.5% of total NHS and social services expenditure and there are currently no treatments available.

Stroke occurs when vessels supplying blood to the brain become blocked and the brain is starved of oxygen. A core area of the brain dies within minutes but it is the threatened area around this core that the treatment may help to salvage.

"The protein targets the molecule that causes inflammation and dramatically reduces the inflammatory markers," said Professor Rothwell, MRC Research Professor and the University's Vice-President for Research.

"In the laboratory we were able to reduce damage to the cells by as much as half; if we could cut cell damage in patients by even a third it would be a very significant step forward in treating stroke."

IL-1ra (interleukin-1 receptor antagonist) is the naturally occurring antagonist of the protein interleukin-1 (IL-1), which the same scientists have shown to cause damage to the brain in experimental stroke and b
'"/>

Source:University of Manchester


Page: 1 2

Related biology news :

1. Mystery Blood Vessel Disorder Implicated In Mini Strokes
2. Stroke symptoms common among general population
3. Protein discovery could unlock the secret to better TB treatment
4. Topical treatment shown to inhibit HIV and herpes simplex virus infection
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. Researchers add new tool to tumor-treatment arsenal
7. Potential treatments for neurofibromatosis
8. Nanoparticles offer new hope for detection and treatment
9. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
10. PET/CT can identify new cancer lesions at early stage, allowing for prompt treatment
11. New understanding of DNA repair may pave way to cancer treatments
Post Your Comments:
(Date:7/24/2008)...D, Ore. July 23, 2008. A fire is currently burning...about fire behavior about 2 years ago. Managers us...ional Reserve (LSR) study in the planning, analysi... Cold Springs fire is now active., The Gotchen L... Washington, and covers about 15,000 acres of the ...
(Date:7/23/2008)...ALLAS July 24, 2008 One of the reasons people on...ey reduce their intake of fructose, a type of suga...g to a researcher at UT Southwestern Medical Cente...of clinical nutrition and lead author of a study a...rition , said her team,s findings suggest that the...
(Date:7/23/2008)...S, Ohio A recent study shows that popular fish oi...s of small, acute wounds in human skin. But whethe...ally suspected, remains a mystery. , The omega-3...red to benefit cardiovascular health and other dis...heir anti-inflammatory properties. But insufficien...
(Date:7/23/2008)...versity of Washington study of top-selling laundry...itted dozens of different chemicals. All six produ...d as toxic or hazardous under federal laws, but no...bels. , "I first got interested in this topic bec...s in public restrooms and the scent from laundry p...
Breaking Biology News(10 mins):Landscape study may offer solutions for fire managers 2Limiting fructose may boost weight loss, UT Southwestern researcher reports 2Limiting fructose may boost weight loss, UT Southwestern researcher reports 3Scientists suspect omega-3 fatty acids could slow acute wound healing 2Scientists suspect omega-3 fatty acids could slow acute wound healing 3Scientists suspect omega-3 fatty acids could slow acute wound healing 4Toxic chemicals found in common scented laundry products, air fresheners 2Toxic chemicals found in common scented laundry products, air fresheners 3Disability payments may spur drug abuse 14 1Disability payments may spur drug abuse 14 2Chromatin remodeling complex connected to DNA damage control 12 1Chromatin remodeling complex connected to DNA damage control 12 2Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer 10 1Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer 10 2Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer 10 3New study shows promise in reducing surgical risks associated with surgical bleeding 8 1New study shows promise in reducing surgical risks associated with surgical bleeding 8 2
...e, they are nothing but a cosmetic nuisance. But s...elanocytes start dividing abnormally to form a dea...e in 65 Americans born this year will be diagnosed.... , Scientists know that 30 percent of all melano...moles contain cancer-causing mutations. What scien...
...al Center have visualized in a living animal how c... splice genetic material to create unique and vari...de in mice, help explain a key wonder of human bio... individual’s body can produce different proteins ...eins, in turn, dictate the function of each tissue...
...rker than female flies. The hair-like bristles on ...equipment, of course, is different, too. , "Doub...ody differences. Doublesex, new research shows, is... finding, made by Brown University biologists, deb...re built by separate sets of genes. Rather, resear...
...ord University won the Nobel Prize in Chemistry fo...karyotic transcription, in which enzymes give “voi...t serve as templates for protein in organisms from... report in the December 1, 2006 issue of the journ...hat reveal another critical piece of the puzzle: h...
Other Biology News:Why don't all moles progress to melanoma? 2Why don't all moles progress to melanoma? 3Living view in animals shows how cells decide to make proteins 2Living view in animals shows how cells decide to make proteins 3With fruit fly sex, researchers find mind-body connection 2With fruit fly sex, researchers find mind-body connection 3Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity 2Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity 3Nobel Laureate finds 'elegant' explanation for DNA transcribing enzyme's high fidelity 4
(Date:7/25/2008)...Newswire/ -- BioTrends Research Group, Inc.,releas...M) publication, a,syndicated report offering compr...ia and bone and mineral metabolism in Chronic Kidn... information from 182 US,Nephrologists -- data wer...ne 2008., In the renal anemia market, while the u...
(Date:7/25/2008)...X, CALGARY, July 25 / Resv...X:RVX) is pleased to announce effective,immediatel...irectors. On,the subject of her appointment Jan Gr...xciting opportunity for me. The Company has done a...linical trials. I expect the next,foreseeable futu...
(Date:7/25/2008)...swire-FirstCall/ -- Caraco Pharmaceutical,Laborato...first quarter of,Fiscal 2009, ended June 30, 2008,...or the corresponding period of Fiscal 2008. This r...er of Fiscal 2008. Pre-tax income grew,to $14.6 mi...ared to a,pre-tax income of $9.6 million during th...
(Date:7/25/2008)...25 /- REvolution Computing will,lead ...R product at the,upcoming BioC 2008 conference in ... REvolution Computing Director of Community, Dr. D... Training Manager, and Martin Morgan of,the Fred H...ting,s BioC lab,will introduce participants to the...
Breaking Biology Technology:BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3Jan Gray Joins Resverlogix Board of Directors 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 3Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 4Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 5Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 6Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 7REvolution Computing Offers Hands-On Tutorial of NWS Parallel Computing Environment at BioC 2008 2
...umni Research Foundation has hired a new director...on since December 1 and was officially announced W...y University of Wisconsin-Madison researchers to c...t of its $1.4 billion portfolio in companies that ... who retired at the beginning of the year. Though...
... the move was the theme of Governor Jim Doyles spe... the state Capitol. , ,Doyle, a Democrat, delivere...uses of the state Legislature, putting forth a mos...cognition to both Democrats and Republicans. WTN c...n business and technology. , , Forbes ranking : Do...
...e announced Wisconsins next energy move would be a...ofuels Initiative. The initiative opens up funding... corn, and research where they would be most effec... but we have the corn for ethanol, Doyle said in a... we have ingenuity. , ,According to gubernatorial ...
...tentially fraudulent Web sites soliciting donation...mi have turned up in a search conducted by NamePr...and MasterCard International. , ,The two compani... suspend the activity of Web sites and e-mail dist... such as identity theft. Their partnership Stop Id...
Other Biology Technology:New WARF investment director plans to keep steady course 2Doyle names business and technology successes, plans for 2005 2Doyle names business and technology successes, plans for 2005 3Governor wants $2 million for biofuels in budget 2NameProtect roots out fake tsunami-related donation sites 2
...search with S. aureus, Sigma-Genosys has developed...s PCR primers to amplify all open reading frames (...s are included to amplify ORFs that are unique to ...RFmer set contains primers to amplify all 2,731 OR...
... a high-capacity, plug-and-play bench top automati...rs and liquid handling systems together with expan...d intuitive and powerful software. Whether you are...ral modules together to complete a robotic system,...
...ical to medium scale affinity purification of STag.... Sufficient reagents are provided for purificatio...aturing conditions. Crude samples are incubated wi...Tag fusion proteins. After unbound proteins are wa...
... ,Tryptone 5.0 ,Yeast extract 2.5 ,Sodium... ammonium citrate 0.250 ,IPTG 0.025 ,Kanamycin...complete growth medium containing S-Gal (3,4-cyclo...utoclavable chromogenic substrate for -galactosida...
Biology Products: