Navigation Links
Stroke treatment a step closer after trial

A potential new treatment for stroke has taken a major step forward following promising results from the first clinical trial.

Researchers at The University of Manchester have shown in laboratory studies that a naturally occurring protein called IL-1ra protects brain cells from injury and death.

The team, led by Professor Nancy Rothwell and Dr Pippa Tyrrell, have now reported the results of the first small trial of IL-1ra in patients, which are published in the Journal of Neurology and Neuropsychiatry.

"The study was designed to test if IL-1ra is safe in stroke patients and showed promising results," said Professor Rothwell, a world-renowned neuroscientist based in the University's Faculty of Life Sciences.

"The trial was a definite step in the right direction and may lead to a full trial to test its effectiveness next year."

Stroke is the UK's third biggest killer and the biggest cause of disability, affecting 100,000 people each year. It accounts for 6.5% of total NHS and social services expenditure and there are currently no treatments available.

Stroke occurs when vessels supplying blood to the brain become blocked and the brain is starved of oxygen. A core area of the brain dies within minutes but it is the threatened area around this core that the treatment may help to salvage.

"The protein targets the molecule that causes inflammation and dramatically reduces the inflammatory markers," said Professor Rothwell, MRC Research Professor and the University's Vice-President for Research.

"In the laboratory we were able to reduce damage to the cells by as much as half; if we could cut cell damage in patients by even a third it would be a very significant step forward in treating stroke."

IL-1ra (interleukin-1 receptor antagonist) is the naturally occurring antagonist of the protein interleukin-1 (IL-1), which the same scientists have shown to cause damage to the brain in experimental stroke and b
'"/>

Source:University of Manchester


Page: 1 2

Related biology news :

1. Mystery Blood Vessel Disorder Implicated In Mini Strokes
2. Stroke symptoms common among general population
3. Protein discovery could unlock the secret to better TB treatment
4. Topical treatment shown to inhibit HIV and herpes simplex virus infection
5. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
6. Researchers add new tool to tumor-treatment arsenal
7. Potential treatments for neurofibromatosis
8. Nanoparticles offer new hope for detection and treatment
9. Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment
10. PET/CT can identify new cancer lesions at early stage, allowing for prompt treatment
11. New understanding of DNA repair may pave way to cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stroke treatment step closer after trial

(Date:5/22/2013)... U.S. Forest Service scientists are part of "Landscapes ... the TKF Foundation, will examine how collaborative planning and ... from tragedy. , The TKF Foundation announced today that ... for grant funding. In addition to research on the ... and resiliency, the 3-year, $585,000 grant will contribute to ...
(Date:5/22/2013)... technique that can detect molecular variants in chemical mixtures ... the most important, though time-consuming, processes in analytical chemistry. ... Nature , post-doctoral researcher David Patterson, Professor of Physics ... for Free-Electron Laser Science (CFEL) in Hamburg, Germany developed ... identify molecular variants apart, and to determine how much ...
(Date:5/22/2013)... engineering drastically reduces the time and effort needed ... of biotechnology, scientists are reporting. Published in the ... paves the way for more rapid development of ... other activities. , Keith Shearwin and colleagues explain ... genetic material DNA into a bacterium,s genome is ...
Breaking Biology News(10 mins):'Landscapes of Resilience' to study how people use nature as a source of recovery 2Detecting mirror molecules 2Detecting mirror molecules 3
... have been shown to adversely affect shell-forming creatures and corals, ... of Oceanography at UC San Diego has shown for the ... in fish. A brief paper published in the June ... in which fish that were exposed to high levels of ...
... the bustling economy of the cell, little bubbles called ... from the port - the cell membrane. Some of ... the cell,s protein factory. Scientists have long believed ... life-supporting nutrients and proteins through an independent process. By ...
... 2009 Scientists at Burnham Institute for Medical Research ... interfere with gene expression) reduce HIV replication and infectivity ... role in controlling the HIV life cycle. The study ... mechanism to help the virus hide from the immune ...
Cached Biology News:High carbon dioxide levels cause abnormally large fish ear bones 2Cells use import machinery to export their goods as well 2Cells use import machinery to export their goods as well 3MicroRNAs help control HIV life cycle 2
(Date:5/23/2013)... (PRWEB) May 23, 2013 SynCardia Systems, ... and only FDA, Health Canada and CE (Europe) approved ... Centre in Scotland, which boasts more than 380,000 visitors ... Heart powered by the Freedom® portable driver as ... the most advanced exhibitions of its kind. , ...
(Date:5/23/2013)... 2013 Ralph Huber, President of PHI ... management products and emergency survival kits would be on ... made at the quarterly executive board meeting on May 22nd. ... silence for the Oklahoma tornado victims and used the opportunity ... their emergency kits is paramount. “When disaster strikes,” he ...
(Date:5/22/2013)... Cambridge Semantics was one of just ... Day” on Capitol Hill, hosted by The Data ... others to showcase how innovative data management applications can address ... (DATA Act). , Originally introduced in 2011 by Committee ... Mark Warner (D-VA ), the DATA Act is ...
(Date:5/22/2013)... NEW ORLEANS , May 22, 2013 ... of regenerative medicine, presented new data generated in collaboration ... (a leading health economics consultancy) demonstrating the significant healthcare ... and venous leg ulcers (VLU) place upon the US ... research, which reveal annual costs of up to $15 ...
Breaking Biology Technology:SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 2SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 3PHI Emergency Management on Announces Father's Day Specials All Emergency Survival Kits 2Cambridge Semantics Underscores Need for Smart Data during “Data Demonstration Day” on Capitol Hill 2Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 2Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 3Organogenesis Presents Findings from Groundbreaking Research Highlighting the Healthcare Resource and Economic Burden of Venous Leg Ulcers and Diabetic Foot Ulcers 4
... Regenerative Medicine editorial board. , ... Vancouver, BC (PRWEB) ... announced today the appointment of its principle consultant, R. Lee Buckler, ... , , , ,Published by Future Medicine, Regenerative Medicine has become ...
... The inaugural year of The Kavli Prize will be ... Haakon Magnus presenting the prize to the seven Kavli laureates. ... will give lectures throughout the week. , , Note: The award ... be a press briefing at 11.15 AM (CET), September 9, ...
... Amylin,Pharmaceuticals, Inc. (Nasdaq: AMLN ) and Eli Lilly ... today provided context and additional information,regarding the August 18, ... prior alert for BYETTA(R) (exenatide) injection referencing,pancreatitis. The companies ... as well as others, and previously reported these cases ...
Cached Biology Technology:Regenerative Medicine Appoints Cell Therapy Group Consultant to Editorial Board 2Inaugural Kavli Prize ceremony and symposia: Sept. 8-11 (Oslo, Norway) 2Inaugural Kavli Prize ceremony and symposia: Sept. 8-11 (Oslo, Norway) 3Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA 2Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA 3Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA 4Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA 5Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA 6
One-step, microplate or cuvet, colorimetric, detection range 0.1 mg/dL to 3 mg/dL. Procedure: 10 min....
... sizing single-stranded RNA ranging from 0.5 kb to 10 ... consists of nine bands in even increments (0.5 1 ... to simplify size estimation. The 1.5 kb band is ... and identification of RNA bands on the gel. All ...
... Serum • Mouse serum is collected off the clot ... weeks of age. Available Anticoagulants: N-02: ... K2EDTA N-08: Potassium Oxalate N-10: ... ACD N-07: CPD N-09: ...
Rubeola (Measles) Antigen Preservative: No Preservatives...
Biology Products: