Navigation Links
Stress may help cancer cells resist treatment, research shows

Scientists from Wake Forest University School of Medicine are the first to report that the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to cell death.

"These data imply that emotional stress may contribute to the development of cancer and may also reduce the effectiveness of cancer treatments," said George Kulik, D.V.M., Ph.D., an assistant professor of cancer biology and senior researcher on the project.

The study results are reported on-line in the Journal of Biological Chemistry and will appear in a future print issue.

Levels of epinephrine, which is produced by the adrenal glands, are sharply increased in response to stressful situations and can remain continuously elevated during persistent stress and depression, according to previous research. The goal of the current study was to determine whether there is a direct link between stress hormones and changes in cancer cells.

While a link between stress and cancer has been suggested, studies in large groups of people have been mixed.

"Population studies have had contradictory results," said Kulik. "We asked the question, ‘If stress is linked to cancer, what is the cellular mechanism??There had been no evidence that stress directly changes cancer cells."

Studying prostate and breast cancer cells in the laboratory, Kulik and colleagues found that a protein called BAD ?which causes cell death ?becomes inactive when cancer cells are exposed to epinephrine.

Kulik said that connection between stress and prostate cancer has been largely unexplored. However, recent studies suggest that these laboratory findings may apply to cancer patients.

"A study from Canada showed that men who took beta blockers for hypertension for at least four years had an 18 percent lower risk of prostate cancer," said Kulik. "These drugs block the effects of epinephrine, which could explain the finding.
'"/>

Source:Wake Forest University Baptist Medical Center


Page: 1 2

Related biology news :

1. Stressed cells spark DNA repair missteps and speed evolution
2. Research Permits First-Ever Visualization of Psychological Stress in the Human Brain
3. Stress substantially slows human bodys ability to heal
4. Stress hormones may play new role in speeding up cancer growth
5. Viral DNA sequence a possible trigger for breast cancer
6. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
7. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
8. Columbia research lifts major hurdle to gene therapy for cancer
9. Combination therapy boosts effectiveness of telomere-directed cancer cell death
10. Mitochondrial DNA mutations play significant role in prostate cancer
11. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stress may help cancer cells resist treatment research shows

(Date:2/18/2015)... (NASDAQ: CPHD ) today announced that its executives ... to participate via webcast. , Cowen and Company Health ... 3, 2015 at 11.20 a.m. Eastern Time , Raymond ... Wednesday, March 4, 2015 at 10.25 a.m. Eastern Time ... these events, please visit Cepheid,s website at http://ir.cepheid.com ...
(Date:2/11/2015)... 11, 2015 According ... Control Market by Product (Cards and Readers, Biometrics, Controllers, ... Government, Industrial, Healthcare, Education) and By Geography - Global Forecast and ... the Access Control Market is expected to ... a CAGR of 10.6% between 2014 and ...
(Date:2/5/2015)... TRIANGLE PARK, N.C. , Feb. 5, 2015 /PRNewswire/ ... a specialist logistics company and has launched a new ... only Clinical Logistics Organization (CLO).  The new campaign focuses ... emphasis on patient, protocol and shipments. The ... First , aligns Marken,s priorities with its client,s ...
Breaking Biology News(10 mins):Cepheid to Webcast Upcoming Financial Presentations 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken Launches New Patient-Centric Campaign 2
... in the November 2008 issue of BioScience ... an Era of Genomics and Proteomics. David Emerson, Liane ... genomics and proteomics are changing techniques used for identifying ... levels of discrimination, but standards for their use must ...
... known that it,s possible for one gene to produce slightly ... certain sequences from the messenger RNA. Now, an MIT team ... both far more prevalent and varies more between tissues than ... 94 percent, generate more than one form of their protein ...
... to immune system cells called T-lymphocytes that target a ... fight a form of childhood cancer called neuroblastoma, said ... Hospital in a report that appears online today in ... a way to convert a naturally occurring problem into ...
Cached Biology News:BioScience tip sheet, November 2008 2Human genes sing different tunes in different tissues 2A double-barreled immune cell approach for neuroblastoma 2
(Date:3/3/2015)... astronaut Scott Kelly , who is making final preparations ... and working on the International Space Station, will be available ... Monday, March 9. Kelly will participate from ... of his training. The interviews will be preceded at 5 ... training and previous spaceflights. To schedule an interview, ...
(Date:3/3/2015)... /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), a life sciences company ... for advanced microarray diagnostics, today announced it has ... Management team. In his capacity as CFO he ... a development stage to a commercially successful company ... capital market strategy and to secure funding to ...
(Date:3/3/2015)... March 3, 2015 Fried, Frank, Harris, Shriver ... Lewis has joined the Firm as a partner ... New York office. Mr. Lewis ... as well as other intellectual property and general litigation. ... Lewis represents both plaintiffs and defendants in a range ...
(Date:3/3/2015)... March 3, 2015  Rosa & Co. LLC, a ... and simulation research, today announced it has two posters ... for Clinical Pharmacology and Therapeutics meeting in ... Logo - http://photos.prnewswire.com/prnh/20150302/179058LOGO   ... a poster describing a quantitative systems pharmacology approach for ...
Breaking Biology Technology:NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 3Rosa & Co. Announces Two Poster Presentations at the American Society for Clinical Pharmacology and Therapeutics 2015 Annual Meeting 2Rosa & Co. Announces Two Poster Presentations at the American Society for Clinical Pharmacology and Therapeutics 2015 Annual Meeting 3
... Energy is the biggest challenge in the world, and we ... of energy inefficiencies can be attributed to transportation (27 percent), ... calculated by the U.S. Energy Information Administration statistics ... G.P. Yeh of Fermi Labs . He also said ...
... Madison, Wis. - As the completion of an audit ... has abandoned another costly IT project. , ,According to a ... Department of Workforce Development has decided to stop ... track unemployment claims. The system, known as Enhanced Automated Benefits ...
... fellow travelers a thing or two about commuting. , ,The ... an executive-in-residence and one of its portfolio companies, Caden ... , Gregg Fergus And since Fergus has been ... his new posts reduce the distance between home and work. ...
Cached Biology Technology:Energy conservation might take us farther than renewable fuels 2Energy conservation might take us farther than renewable fuels 3Energy conservation might take us farther than renewable fuels 4Energy conservation might take us farther than renewable fuels 5Energy conservation might take us farther than renewable fuels 6State of Wisconsin dumps another tech project 2Biotech executive books a career flight that's closer to home 2Biotech executive books a career flight that's closer to home 3
Request Info...
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Peptide-affinity Purified Polyclonal Antibody to Histamine H2 Receptor...
Biology Products: