Navigation Links
Stress hormones may play new role in speeding up cancer growth

ncer growth.

The Ohio State team wanted to see if the same occurred with other cancer cells.

They turned to cell lines Glaser had developed decades ago to study nasopharyngeal carcinoma (NPC), a serious, incurable head and neck cancer that occurs most frequently among people of Chinese descent.

They treated Glaser's cell line with norepinephrine and, as predicted, the cells all produced MMP-2, MMP-9 and VEGF. This showed that the receptors for this hormone were present on cells in Glaser's cell line, but that might have been just a laboratory aberration in the tissue cultures.

"We needed to see how relevant this finding was to what happened with actual tumors," he said. Glaser asked colleagues for samples of actual NPC tumors to look for the presence of similar receptors. They studied tumor samples which included different types of NPC tumors. All had the sought-after receptors.

"From this we can say that there is likelihood that all NPC tumors will have these receptors as well," he said.

"MMP-2 and MMP-9 contribute to the aggressiveness of these tumors," Yang said. "It isn't clear exactly how they are operating but they may work with VEGF to facilitate blood vessel growth in new tumors so that they can grow."

The target adrenergic receptors for these hormones are well-known to clinicians dealing with high-blood-pressure patients. Typically, such patients are given a class of drugs known as beta-blockers which lead to a lowering of blood pressure levels.

Glaser and Yang wanted to see how these same drugs affected these tumor cells. They added propanol, a beta-blocker, to the tumor cells and then exposed them to both norepinepherine and epinephrine. With the drug present, the levels of MMP-2, MMP-9 and VEGF didn't increase.

"This suggests a new approach to possibly fight some cancers ?the prescribing of beta-blocker-type drugs that would block these receptors and perhaps slow th
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Stressed cells spark DNA repair missteps and speed evolution
2. Research Permits First-Ever Visualization of Psychological Stress in the Human Brain
3. Stress substantially slows human bodys ability to heal
4. Stress may help cancer cells resist treatment, research shows
5. Female sex hormones play a vital role in defense against sexually transmitted diseases
6. Alcohol consumption disrupts breastfeeding hormones
7. Hyena mothers give their cubs a helpful dose of hormones
8. Computational analysis shows that plant hormones often go it alone
9. Viral DNA sequence a possible trigger for breast cancer
10. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
11. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stress hormones may play new role speeding cancer growth

(Date:5/6/2015)... TEL AVIV, Israel , May 6, 2015 /PRNewswire/ ... the world,s most established helmet producer, announced today that ... LifeBEAM Smart Helmet, the world,s first bio-sensing cycling helmet ... will be released in two new colors in order ... demand for the product. In addition, LifeBEAM and Lazer ...
(Date:4/27/2015)... April 27, 2015  For more than four decades, ... has been the premier worldwide event for the unmanned ... a must-attend event for any local, national, or trade ... emerging commercial markets and current applications of unmanned technologies. ... this projected $48 billion industry, and how it will ...
(Date:4/27/2015)... LAUDERDALE, Fla. , Apr. 27, 2015 ... of access control and security systems is pleased to ... the company as a consultant and member of its ... is widely known as a thought leader in ... Distance Learning Technology Group, and has published studies and ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... JOLLA, CAWhen you eat may be just as vital to ... Salk Institute for Biological Studies. Their experiments in mice revealed ... in the liverthe body,s metabolic clearinghouseis mostly controlled by food ... wisdom had it. "If feeding time determines the ...
... gut bacteria bind to the gastrointestinal tract. The protein could be ... be of real benefit to people. , "Probiotics need to interact ... if they attach to surfaces in the gut they are more ... Dr Nathalie Juge from the Institute of Food Research. IFR ...
... NEW YORK (November 24, 2009) -- The Wildlife Conservation Society ... tigers has likely declined significantly due to the rising tide of poaching and ... WCS says the report will help inform Russian officials of what ... ...
Cached Biology News:Feeding the clock 2Feeding the clock 3A sticky solution for identifying effective probiotics 2Report shows dramatic decline in Siberian tigers 2
(Date:5/26/2015)... - Fluorinov Pharma (Fluorinov), a FACIT portfolio company, today ... to its Board of Directors.  His appointment strengthens Fluorinov,s ... Fluorinov accelerates its clinical development activities.  ... pleasure to welcome Luke to the Board of Directors.  ... financial strength and success of multiple organizations," said ...
(Date:5/26/2015)... Just the characterization of being a new breakthrough ... not guarantee immediate acceptance. In particular, a new ... failures is often met with significant skepticism. The ... that is often an unappreciated aspect of scientific innovation. ... has found that building acceptance of its new ...
(Date:5/25/2015)... 25, 2015 Phenome Networks, a ... announced the availability, beginning May 31st, of its next-generation ... Phenome One solidifies Phenome Networks’ lead in the plant ... simple and intuitive breeding workflow based on years of ... customize field design, and more. The new version of ...
(Date:5/22/2015)... May 22, 2015 Knowledgent , ... paper that explores the potential of big data analytics ... paper was developed to help life sciences and healthcare ... data to gain critical business insights. , The life ... of data driven by patient profiling, compliance and regulatory ...
Breaking Biology Technology:Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 3In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 2In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 3Phenome Networks Announces its Next Generation Plant Breeding Management and Analytics Software 2Phenome Networks Announces its Next Generation Plant Breeding Management and Analytics Software 3New White Paper Explores the Potential of Big Data Analytics in Life Sciences and Healthcare 2
... Odijk, you win. The professor of biotechnology at Delft ... best friend in Rice University,s Matteo Pasquali. ... Scientific Research (CNRS), the University of Bordeaux, France, and ... have settled a long-standing controversy in the field of ...
... N.J., Jan. 7, 2011 Savient Pharmaceuticals, Inc. (Nasdaq: ... activities related to the U.S. launch and commercialization of KRYSTEXXA, ... of chronic gout in adult patients refractory to conventional therapy. ... the promotional launch of KRYSTEXXA in the first quarter of ...
... University of California, Santa Cruz, have identified a key molecule ... bone marrow. The findings, reported in the January issue of ... the safety and efficiency of bone marrow transplants. Bone ... to treat cancers such as lymphoma and leukemia and other ...
Cached Biology Technology:Bendy tubes get around 2Bendy tubes get around 3Savient Pharmaceuticals Provides Business Update 2Savient Pharmaceuticals Provides Business Update 3Savient Pharmaceuticals Provides Business Update 4Savient Pharmaceuticals Provides Business Update 5Savient Pharmaceuticals Provides Business Update 6Stem cell discovery could lead to improved bone marrow transplants 2
... a unique alternative to traditional TBE ... electrophoresis buffers. Bionic Buffer allows for ... times, and high-resolution band separation. -Application: ... after dilution to working 1x concentrations. ...
Fujifilm Pictro-Color Process for sharp, clear reproduction comparable to silver-halide photography. Photorealistic 400 dpi quality. A4 and A5 output....
Sufficient reagents for 50 applications.Mitochondria Isolation Kit Reagent A, 50 ml Mitochondria Isolation Kit Reagent B, 500 l Mitochondria Isolation Kit Reagent C, 70 ml...
... loxP-amp-loxP cassette is designed to allow ... prokaryotic promoter gb2 driving the gene for ... of the Em7 promoter. It mediates higher ... promoter. A synthetic polyadenylation signal terminates the ...
Biology Products: