Navigation Links
Stress hormones may play new role in speeding up cancer growth

New research here suggests that hormones produced as during periods of stress may increase the growth rate of a particularly nasty kind of cancer.

The study showed that an increase in norepinephrine, a stress hormone, can stimulate tumor cells to produce two compounds. These compounds can break down of the tissue around the tumor cells and allow the cells to more easily move into the bloodstream. From there, they can travel to another location in the body to form additional tumors, a process called metastasis.

The research also suggests the same hormone can also stimulate the tumor cells to release another compound that can aid in the growth of new blood vessels that feed cancer cells, hastening the growth and spread of the disease. The work was reported in the latest issue of the journal Cancer Research.

"This opens up an entirely new way of looking at stress and cancer that's different from current interpretations," explained Ronald Glaser, a professor of molecular virology, immunology and medical genetics, and director of the Institute for Behavioral Medicine Research at Ohio State University .

Glaser and Eric Yang, a research scientist in the same institute, focused on the role of these three compounds. Two of them, both matrix metalloproteinases -- MMP-2 and MMP-9 -- play a role in breaking down the scaffolding that cells attach to in order to maintain their shape. The third compound, vascular endothelial growth factor (VEGF), is important in the growth of new blood vessels into tumor cells.

Earlier work by researcher Anil Sood at the University of Texas had shown that the same stress hormones can stimulate ovarian tumor cells to produce these three compounds. The key to that discovery was that the two stress hormones ?epinephrine and norepinephrine ?would bind to places on the surface of ovarian cancer cells, called adrenergic receptors, and stimulate the release OF MMP-2, MMP-9 and VEGF which might then foster ca ncer growth.

The Ohio State team wanted to see if the same occurred with other cancer cells.

They turned to cell lines Glaser had developed decades ago to study nasopharyngeal carcinoma (NPC), a serious, incurable head and neck cancer that occurs most frequently among people of Chinese descent.

They treated Glaser's cell line with norepinephrine and, as predicted, the cells all produced MMP-2, MMP-9 and VEGF. This showed that the receptors for this hormone were present on cells in Glaser's cell line, but that might have been just a laboratory aberration in the tissue cultures.

"We needed to see how relevant this finding was to what happened with actual tumors," he said. Glaser asked colleagues for samples of actual NPC tumors to look for the presence of similar receptors. They studied tumor samples which included different types of NPC tumors. All had the sought-after receptors.

"From this we can say that there is likelihood that all NPC tumors will have these receptors as well," he said.

"MMP-2 and MMP-9 contribute to the aggressiveness of these tumors," Yang said. "It isn't clear exactly how they are operating but they may work with VEGF to facilitate blood vessel growth in new tumors so that they can grow."

The target adrenergic receptors for these hormones are well-known to clinicians dealing with high-blood-pressure patients. Typically, such patients are given a class of drugs known as beta-blockers which lead to a lowering of blood pressure levels.

Glaser and Yang wanted to see how these same drugs affected these tumor cells. They added propanol, a beta-blocker, to the tumor cells and then exposed them to both norepinepherine and epinephrine. With the drug present, the levels of MMP-2, MMP-9 and VEGF didn't increase.

"This suggests a new approach to possibly fight some cancers ?the prescribing of beta-blocker-type drugs that would block these receptors and perhaps slow th e progression of the disease," Glaser said.

"Using this approach may not cure this cancer but perhaps we could slow down its growth, making the tumor more sensitive to anti-cancer therapy, and therefore extending the patient's lifespan and improve their quality of life."
'"/>

Source:Ohio State University


Related biology news :

1. Stressed cells spark DNA repair missteps and speed evolution
2. Research Permits First-Ever Visualization of Psychological Stress in the Human Brain
3. Stress substantially slows human bodys ability to heal
4. Stress may help cancer cells resist treatment, research shows
5. Female sex hormones play a vital role in defense against sexually transmitted diseases
6. Alcohol consumption disrupts breastfeeding hormones
7. Hyena mothers give their cubs a helpful dose of hormones
8. Computational analysis shows that plant hormones often go it alone
9. Viral DNA sequence a possible trigger for breast cancer
10. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
11. Its not all genetic: Common epigenetic problem doubles cancer risk in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2016)... NEW YORK , March 9, 2016 ... current and future states of the RNA Sequencing (RNA ... in segments such as instruments, tools and reagents, data ... Analyze various segments of the RNA-Sequencing market such ... RNA-Sequencing services Identify the main factors affecting each segment ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
(Date:3/3/2016)... 2016  FlexTech, a SEMI Strategic Association Partner, awarded ... & Development, Leadership in Education, and, in a category ... th year of the FLEXI Awards and the ... from past years . Judging was done on ... of criteria, by a panel of non-affiliated, independent, industry ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... Raleigh, NC (PRWEB) , ... May 20, 2016 , ... ... cells, suggesting that it may offer a new way to treat the disease. Surviving ... read it now. , Scientists from several Korean institutions based their mesothelioma study ...
(Date:5/19/2016)... MAPLE RIDGE, British Columbia , May 19, ... of AdvanTec Global Innovations Inc. (AGI), based out ... recently added Greenlane Biogas Ltd. to its ... a 2-year contract manufacturing agreement. AFS along with ... Bending Technologies (ABT) is a vertically integrated industrial ...
(Date:5/19/2016)... 2016 Regen BioPharma, ... RGBPP) announced today initiation of a preclinical development ... based cancer immunotherapeutic product leveraging its NR2F6 immunological ... a generation of cord blood derived killer cells ...  The product in development will be a "universal ...
(Date:5/18/2016)... ... May 18, 2016 , ... Shimadzu ... at The University of Toledo. This two-day camp will take place annually starting ... the field of pharmaceutical sciences in preparation for a university academic program. ...
Breaking Biology Technology: