Navigation Links
Stopping smallpox in its tracks: A new anti-viral approach

Natural or deliberate exposure to smallpox poses a great health threat, especially since routine smallpox vaccinations have been discontinued and no clinically approved treatment currently exists. In the February 1 issue of the Journal of Clinical Investigation, Ellis Reinherz and colleagues from Harvard Medical School propose a new antiviral therapy ?a low molecular weight inhibitor of signaling mediated by the smallpox growth factor (SPGF).


SPGF targets the erbB-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infected mice.

In an accompanying commentary, Anthony Fauci and Mark Challberg from the National Institutes of Health point out that this approach "may serve to turn the tables on the virus by interfering with the very pathways that are required for viral replication and extrusion."

This study demonstrates, for the first time, that chemical inhibition of host cell signaling pathways exploited by infectious agents represents a new avenue for development of anti-viral therapeutics. These inhibitors, which are already in use in human anti-tumor therapy, may have widespread applications in human viral infections and protection from smallpox. These findings reveal a new approach to the identification and development of antiviral compounds. This is especially critical at a time when the threat of smallpox as a biological weapon is high.


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
2. Stopping plants from getting sick
3. Secret of smallpoxs success may lead to bioterror cure
4. LIAI scientists make major finding on potential smallpox treatment
5. Researchers develop new testing methods for potential monkeypox or smallpox outbreak
6. Serious adverse reactions to smallpox vaccine appear to be limited
7. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
8. Defective immune system response to smallpox vaccine detailed in new study
9. Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack
10. Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
11. Using natures most primitive anti-viral defense system to find new approaches to cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stopping smallpox its tracks new anti viral approach

(Date:8/19/2014)... fish purchased at retail seafood counters in 10 ... can expose consumers to unexpectedly high levels of ... falsely present a fish of the same species, ... dangerous mislabeling offense, according to new research by ... labeling of seafood is essential to allow consumers ...
(Date:8/19/2014)... University scientists have identified a biomarker strongly associated ... that is resistant to many types of chemotherapy. ... smart target for new therapeutics designed to treat ... patient data taken from The Cancer Genome Atlas, ... Tell used powerful computational and bioinformatics techniques to ...
(Date:8/19/2014)... -- ( Aug. 19, 2014 ) -- Scientists at ... to pick up and transfer single cells using a ... slightly. They describe this engineering feat and preliminary test ... of the American Chemical Society . , "Studying single ... in current biomedical research," said nanomedicine department. faculty member ...
Breaking Biology News(10 mins):Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3Moving single cells around -- accurately and cheaply 2
... together how the hominid Australopithecus sediba ( Au. ... ago. Their research, which appears in six papers in the ... that Au. sediba had a notable feature that ... flexible lower back. Together, the studies offer a comprehensive ...
... Boston University School of Medicine (BUSM) have pinpointed a ... airway cells harvested utilizing a minimally invasive procedure. The ... could lead to new treatments and ways to monitor ... online in the American Journal of Respiratory and ...
... On April 11 th JoVE ( Journal ... by Dr. Aydogan Ozcan demonstrating how a cell phone camera can ... make it possible for areas with limited resources to easily run ... patients. , In the new video article electrical and ...
Cached Biology News:New research reveals how human ancestor walked, chewed, and moved 2New research reveals how human ancestor walked, chewed, and moved 3BUSM researchers identify novel approach to study COPD and treatment efficacy 2BUSM researchers identify novel approach to study COPD and treatment efficacy 3Cell phone camera photographs microscopic cell samples 2
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
(Date:8/19/2014)... , Aug. 19, 2014 Research and ... Fuel Cells (SOFCs) - Global Strategic Business Report" report ... worldwide markets for Solid Oxide Fuel Cells (SOFCs) in US$ ... Canada , Europe , ... estimates and forecasts are provided for the period 2012 through ...
(Date:8/19/2014)... Md. , Aug. 19, 2014 CSSi, ... research industry, recently announced the formation of the company,s ... to announce the addition of Dr. William E. ... - http://photos.prnewswire.com/prnh/20140818/136957 The MCAB, ... a variety of therapeutic areas and set strategic goals ...
(Date:8/19/2014)... 2014 Sales Horizons, a leader in ... online sales skills training course to help companies ... clinical staff spend the majority of their time on ... center, or physician practice – providing support and education ... there? Sales Horizons believes clinical staff are and should ...
Breaking Biology Technology:Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 2Sales Horizons Launches a New Online Sales Training Course for MedTech Clinical Staff to Develop Their Sales Skills 3
... , WILMINGTON, ... AZN ) and the University of Virginia ... into a strategic research collaboration to enhance development of ... a secondary focus on peripheral vascular disease (PAD). , ...
... Dec. 15 The Mosaic Company (NYSE: MOS ) plans ... financial tables on Tuesday, January 5, 2010, after the close of ... available on Mosaic,s website at mosaicco.com/investors. , The Company ... 6, 2010, to discuss the results. The call will begin ...
... , PHILADELPHIA, Dec. 15 The ... is pleased to announce the full agenda for the ... will take place at the Loews Philadelphia, on March 16-17, ... professionals have attended this premier event since its inception, and ...
Cached Biology Technology:AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 2AstraZeneca and the University of Virginia Sign Strategic Research Collaboration to Develop Novel Treatments for Cardiovascular Disease 3Mosaic Announces Second Quarter Fiscal Year 2010 Earnings Release and Conference Call 2CBI Announces the Agenda for Their 6th Annual Pharmaceutical/Biotech Accounting and Reporting Congress 2
...
... contains the basic components required for the ... and recombinant rat Thymus Chemokine-1 in cell ... sufficient materials to run ELISAs on approximately ... conditions are met: The assay ...
Blimp-1 (H-150)...
Mouse Galectin-1 Affinity Purified Polyclonal Ab...
Biology Products: