Navigation Links
Stem cells in bone marrow replenish mouse ovaries

Previously unrecognized stem cells found in the bone marrow and blood of mice can "restock" a depleted ovary with new egg cells within weeks, according to new research published in this week's issue of the journal Cell.

This finding provides direct evidence to overturn a long-held dogma in reproductive biology, that female mice generate egg cells only during fetal development and thus are born with a finite stock of eggs that declines throughout life. The new report significantly extends earlier work from the same research team reporting the first preliminary evidence that ovaries of mice can be renewed with new eggs in adulthood.

The new study suggests an unexpected source for the progenitor cells that can jumpstart new egg cell production--outside of the ovary--say Jonathan Tilly and colleagues at Massachusetts General Hospital and Harvard Medical School.

The finding is "really revolutionizing how we think about female reproductive function," Tilly says.

With the help of several genetic markers that are found in germ cells, the master cells that eventually give rise to the egg and sperm, the team shows evidence for the existence of germ cell progenitors, putative stem cells, in mouse bone marrow and blood. In addition, the researchers also found these markers in human bone marrow and blood.

Remarkably, the researchers found that bone marrow or blood cell transplants appear to completely revive the ovaries of female mice sterilized by chemotherapy. Just 24 hours after a transplant, the sterilized mice had new egg cells and follicles, the nurturing group of cells that encloses each egg cell. Two months after bone marrow transplant, the ovaries of normal mice and mice that had undergone chemotherapy appeared nearly identical, Tilly and colleagues discovered.

Expression of a germ cell marker in bone marrow fluctuated regularly with the female mouse's estrous cycle, much like the cyclical rise and fall of certain hormones. Further results suggest that the ovary itself is sending out a chemical signal to the bone marrow, readying the progenitor cells to travel to the ovary and restock its egg cell supply.

Although it is not yet clear whether the egg cells (oocytes) generated following bone marrow transplants can mature and be fertilized to give rise to viable mouse pups, the findings provide an important first step toward investigating such potential for restoring fertility. In addition, the findings open the door for future studies examining whether restoration of ovaries could postpone the hormonal effects of menopause and could represent an alternative to hormone replacement therapy. Finally, the researchers would like to find out whether these stem cells could be coaxed to produce eggs in the laboratory, potentially providing a new source of eggs for therapeutic cloning.

Johnson et al.: "Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood." Publishing in Cell, Vol. 122, pages 303?15, July 29, 2005, DOI 10.1016/j.cell.2005.06.031. www.cell.com


'"/>

Source:Cell Press


Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... the addition of the "Global Facial ... offering. --> http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... Markets ( http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the ...
(Date:2/3/2016)... Calif. , Feb. 3, 2016 Vigilant ... Police Department in Missouri ... license plate reader (LPR) data from Vigilant Solutions. ... hit-and-run case in which the victim was walking out of a convenience ... parking space next to his vehicle, striking his vehicle ...
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... -- Sangamo BioSciences, Inc. (NASDAQ: SGMO ), the leader ... Lanphier , Sangamo,s president and chief executive officer, will ... Therapeutic ® development programs and an overview of ... Thursday, February 11, 2016, at the Leerink Partners 5 ... being held in New York . ...
(Date:2/4/2016)... 4, 2016 Beike Biotechnology, the ... attended a ceremony in late 2015 to mark their ... in 2016. --> --> ... for Personalized Cell Therapy" was hosted by the Shenzhen ... both subsidiaries of Beike Biotechnology Co., Ltd. ...
(Date:2/4/2016)... , February 4, 2016 ... a biotechnology acceleration company is pleased to provide the following ... --> Over the last 3 months we have ... securities purchase agreements exceeding $1,000,000. As a result, we have ... Mannin Research Inc. license agreement and expect that development to ...
(Date:2/4/2016)... Sinovac Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: ... China , today announced that the ... February 4, 2016 a preliminary non-binding proposal letter, dated ... V-Ming ( Shanghai ) Investment Holdings Co., ... Shenzhen ) Fund Management Co., Ltd., Beijing ...
Breaking Biology Technology: