Navigation Links
Stem cells from muscles can repair cartilage

ous BMP-4 supplied by MDSCs genetically modified to express BMP-4 over an extended period of time can enhance articular cartilage healing," the authors state. They note that using fibrin glue enabled the cells to settle even in narrow clefts and has no adverse effects on cell viability.

The study also included culturing MDSC and MDSC-B4 in vitro in three different types of media and found that MDSC-B4 were able to differentiate into chondrogenic cells (cells that develop into cartilage) depending on the type of medium in which they grew. The addition of transforming grown factor â1 (TGFâ1) to MDSC-B4 did not enhance chondrogenic differentiation.

The authors conclude that skeletal muscle is a promising source of cells that can differentiate into cartilage-producing cells. "The MDSCs used here served as good carriers of a therapeutic gene and enabled the delivery of appropriate amounts of BMP-4 protein to the injury site," they state, adding that the improved repair lasted for 24 weeks following transplantation. Further studies conducted by the authors (not yet published) have produced similar results. They conclude: "These findings suggest that BMP-4 gene therapy based on retrovirally transduced MDSCs is a potential strategy by which to improve articular cartilage healing."

In an accompanying editorial in the same issue, Mary B. Goldring of the New England Baptist Bone and Joint Institute and Harvard Medical School in Boston, MA, notes that although stem cells derived from bone marrow have been extensively investigated for the repair of cartilage defects, the current study is the first to investigate using enriched stem cells from muscle. The author states that the results are encouraging, especially the successful use of fibrin glue to fill in the defect, and that the study "provides proof-of-principle for performing MDSC implantation in cartilage of adult humans, since 12-week-old rats are considered to be young adults." Although recent stud
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stem cells from muscles can repair cartilage

(Date:7/31/2015)... SHENZHEN , Chine, 31 juillet 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) sera organisée par le ... Shenzhen en Chine. ... année. Depuis son inauguration en 2006, l,ICG est ... influentes dans le domaine des « omiques » et c,est ...
(Date:7/31/2015)... , Jul. 31, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... has filed provisional patent 62/198989 for ELECTRONIC ... highlights a method to advance crypto-currencies such as Bitcoin ... a common, uniform way to manage all payments.  ...
(Date:7/27/2015)... July 27, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced that Huawei has selected the ... for its stylish smartwatch. Huawei chose the state-of-the-art ... low power and highly responsive human interface qualities ... designers also required a classic round watch face ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... WASHINGTON, Aug. 17--Researchers are able to achieve extremely ... depletion (STED) microscopy. This cutting-edge imaging system has pushed ... enabling them to image features that are even smaller ... They are able to achieve this extreme vision by ...
... Five days after the Twin Towers collapsed, two geoscientists ... were part of a team that would use remote sensing ... workers, civilians and survivors of the terrorist attacks. One of ... A second was to create a compositional profile of the ...
... have developed a simple, scalable way to align gold ... for emerging biomedical imaging technologies. Aligning gold nanorods ... on the direction in which the nanorods are pointed. ... want to ensure that all of the nanorods are ...
Cached Biology News:Researchers find way to align gold nanorods on a large scale 2
(Date:7/31/2015)... , July 31, 2015 China Cord Blood ... China,s leading provider of cord blood collection, ... storage services, today announced that the Company has filed ... Securities and Exchange Commission. The filed Form 20-F includes ... 31, 2015. The Form 20-F can be accessed by ...
(Date:7/30/2015)... MN (PRWEB) , ... July 31, 2015 , ... Ralco ... Enrichment Center at the Lyon County Fair to be held August 5-9 in Marshall. ... about where their meals come from and how agriculture impacts their daily lives. This ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report ... the current state of the global Propanol market with a focus on the Chinese ... Dow, Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... as 1 cell , Karen Dolter Jeff ... microprep kit provides a,convenient method for isolating total RNA ... bound to a solid support, which eliminates the,need for ... quality, with no detectable DNA contamination and is suitable ...
... transduction pathway of your choice , ... Cloning Systems, Inc. , The PathDetect in ... for assessing the in vivo activation of ... a unique fusion trans-activator,plasmid that expresses pathway-specific ...
... , Eagle Eye Optical Filter Optimized for ... A new optical filter has been developed for the Eagle ... increases contrast and sensitivity when imaging,silver-stained protein gels. , The ... currently sold with an optical filter optimized for imaging nucleic ...
Cached Biology Technology:Fast Isolation of Total RNA from Small Numbers of Cells 2Fast Isolation of Total RNA from Small Numbers of Cells 3Fast Isolation of Total RNA from Small Numbers of Cells 4Fast Isolation of Total RNA from Small Numbers of Cells 5Fast Isolation of Total RNA from Small Numbers of Cells 6New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 2New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 3New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 4New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 5New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 6Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 2Eagle Eye Optical Filter Optimized for Imaging Silver-Stained,Gels 3
RECK (F-20)...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
NAK/TBK1 (CT) Affinity Purified Polyclonal Antibody...
... N-(2-Naphthoyl)-Val-phenylalaninal 2-Naphthoyl-VF-CHO White lyophilized solid. ... A cell-permeable, reversible inhibitor of γ-secretase. Equipotently ... (ED 50 = 2.6 μM) and ... 2.7 μM) in HEK293 cells stably transfected ...
Biology Products: