Navigation Links
Stem cells from brain transformed to produce insulin at Stanford

With careful coaxing, stem cells from the brain can form insulin-producing cells that mimic those missing in people with diabetes, according to a paper published in the April 26 issue of PLoS Medicine.

Although the work is not yet ready for human patients, Seung Kim, MD, PhD, the lead author and assistant professor of developmental biology at the Stanford University School of Medicine, said it could lead to new ways of transplanting insulin-producing cells into people with diabetes, eventually providing a cure for the disease.

In past work, Kim and members of his lab enticed mouse embryonic stem cells to transform into insulin-producing cells. When transplanted into diabetic mice, these cells effectively made up for the lost insulin-producing cells in the pancreas, called islet cells, and treated the diabetes. However, embryonic stem cells are difficult to work with in the lab and most existing human embryonic stem cell lines are contaminated and can't be transplanted into humans.

Kim thought that human neural stem cells may be one way to sidestep the more problematic embryonic stem cells. The study shows that his intuition was correct.

"When you look at islets cells you realize that they resemble neurons," Kim said. Like neurons, islet cells respond to external signals by changing their electrical properties and releasing packages of proteins. In the case of islets, that protein is insulin.

What's more, some neurons in mice and humans take the first steps toward producing insulin. In insects such as fruit flies, the cells that produce insulin and regulate blood sugar are, in fact, neurons. Taken together, this evidence suggested to Kim that neural stem cells may be able to produce insulin.

Despite Kim's informed hunch, the fact that it worked is a bit surprising.

Until recently, people had though that stem cells taken from the brain would only be able to transform into brain-related tissues such as nerves and s
'"/>

Source:Stanford University Medical Center


Page: 1 2 3

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stem cells from brain transformed produce insulin Stanford

(Date:8/31/2014)... for sniffing the highly infectious bacteria C. diff ... been developed by a team at the University of ... has demonstrated that it is possible to identify the ... lead to rapid diagnosis of the condition., What is ... to identify different strains of the disease simply from ...
(Date:8/31/2014)... are not busy attacking us, germs go after each ... spell disaster for the infected microbes: Sometimes viruses actually ... say, expand its diet or better attack its own ... an immune system would robotically destroy anything it recognized ... University have now revealed that one variety of the ...
(Date:8/31/2014)... Nature Climate Change , suggests that if current trends ... the global targets for total greenhouse gas (GHG) emissions in ... think carefully about the food we choose and its environmental ... just one of a number of actions that need to ... is enough food for all. , As populations rise ...
Breaking Biology News(10 mins):Scientists develop 'electronic nose' for rapid detection of C. diff infection 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3Changing global diets is vital to reducing climate change 2Changing global diets is vital to reducing climate change 3Changing global diets is vital to reducing climate change 4
... of Defence (MINDEF) and the Nanyang Technological University (NTU) ... strengthen Singapore,s defence science and technology research and development ... by inking a Memorandum of Understanding (MOU) at the ... the setting up of the Temasek Research Fellowship and ...
... Pharmaceutical Scientists (AAPS) is a professional, scientific society ... government and other research institutes worldwide. Founded in ... the exchange of knowledge among scientists to enhance ... scientific programs, on-going education, information resources, opportunities for ...
... tropical butterfly that potentially makes it able to distinguish between ... from the University of Bristol, UK. The team ... detection of predators, in particular birds. The Blue Morpho ... America, are more famous for their amazing wing colouration and ...
Cached Biology News:MINDEF, NTU join hands to boost Singapore's defense R&D capabilities 2
(Date:8/29/2014)... on electrons, but one of the most promising technologies ... based on light (photons) instead of electrons. First, it ... of single photons and control their direction. Researchers around ... achieve this control, but now scientists at the Niels ... of photons emitted one at a time and in ...
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... A major challenge before new biotechnology start-up ... of Boston-Cambridge, is gaining visibility that can lead to ... Director of Boston’s Adult Stem Cell Technology Center, LLC ... of his company an important priority since he started ... a social media marketing campaign launched earlier ...
(Date:8/28/2014)... Best Sanitizers, Inc., the first company to ... asks food processors and food handling professionals to prepare ... currently using to Best Sanitizers’ Alpet® E3 Plus ... fighting cross-contamination and the spread of pathogens in the ... key criteria that make a hand sanitizer most effective, ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 2The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 3The Adult Stem Cell Technology Center, LLC Participates in Multiple Stem Cell and Regenerative Medicine Conferences Before Year End 4Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3
... A new, one-year, double-blind controlled clinical study shows that ... risk in postmenopausal women with type 2 diabetes [1] ... Peter J. Curtis, Ph.D., et al , funded by ... Ltd., Israel, and Barry Callebaut, the world,s leading manufacturer of ...
... polymers will offer unprecedented control over the final polymer structure ... study published last week in the prestigious journal Nature ... in Sydney and the University of Warwick in the UK ... a combination of segregation and templating a pair of ...
... integrated circuits are found in many applications, from large ... integration is due in part to the semiconductor industry,s ... for decades. However, while silicon-based circuits continue to ... Law the prediction that the number of transistors ...
Cached Biology Technology:New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients 2New Findings of Daily Consumption of Soy Isoflavones and Cacao-Flavonoids in Diabetes Type 2 Patients 3Bio-inspired polymer synthesis enhances structure control 2Next-generation nanoelectronics: A decade of progress, coming advances 2Next-generation nanoelectronics: A decade of progress, coming advances 3
Request Info...
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
Rabbit polyclonal to Somatostatin 28 ( Abpromise for all tested applications). entrezGeneID: 6750 SwissProtID: P61278...
... an essential component of the COP9 signalosome ... cellular and developmental processes. The CSN complex ... (Ubl) conjugation pathway by mediating the deneddylation ... ligase complexes. The complex is also involved ...
Biology Products: