Navigation Links
Stem cells decrease ischemic injury and restore brain function

This is the impressive result of a study carried out by a group of researchers coordinated by Dr. Maria Grazia De Simoni of the Mario Negri Institute in Milan, Italy in cooperation with the Istituto Neurologico Besta (Milan) and the University of Lausanne. The study appears in the April 18th issue of the international, peer-reviewed, open-access online journal of the Public Library of Science, PLoS ONE.

Stroke is the first cause of permanent invalidity and the third cause of death in industrialized countries.

Despite the recent advancements in the management of ischemic patients (early diagnosis, thrombolysis, stroke units and rehabilitation centers), stroke still represents a major and unresolved medical issue.

"Stroke causes the death of many nervous cells that, in theory, could be substituted by stem cells. A few studies have shown that these cells can be effective, although various issues about their use and the mechanisms of their protective action remained unsolved," says Maria Grazia De Simoni.

"Our research has underlined a possible mechanism of action. Once introduced in the area of the brain hit by a stroke, stem cells induce the development of a protective effect in this same area," explains De Simoni. "Therefore, it is not necessary, as proposed in past studies, for stem cells to turn into neurons in order to protect the brain from ischemic injury and restore brain functions. Their presence in brain tissue is sufficient to induce a protective reaction."

Various cells are involved in this reaction, among which the microglia, which has always been thought to have a toxic and inflammatory role. "Instead, we suggest that the microglia also has a protective function,?says De Simoni. “Moreover our research shows that these cells survive in brain tissue only for a few days and then they are eliminated. This is very important given the possibility that stem cells may turn into cancer cells."
'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stem cells decrease ischemic injury and restore brain function

(Date:4/17/2014)... Luca Razzari of the nergie Matriaux Tlcommunications Research ... the John R. Evans Leaders Fund of the ... of state-of-the-art biotech and nanophotonics equipment. To this ... Ministre de l,Enseignement suprieur, de la Recherche, de ... new laboratories will help us develop new approaches ...
(Date:4/17/2014)... . Our eyes ... us with a continuous stream of information about our own ... in a car the world glides by us and ... effort, our brain calculates self-motion from this "optic flow". This ... gaze during our own movements. Together with biologists from the ...
(Date:4/17/2014)... Calif. One day about eight years ago, ... California, Riverside, and her father were on a field trip ... upon an orchid they had never seen before. , Unable ... on orchids. The orchid turned out to be an ... Lophiaris silverarum . , "Lophiaris" is the genus name, ...
Breaking Biology News(10 mins):New state-of-the-art biotech and nanotech equipment for INRS 2How vision makes sure that little fish do not get carried away 2How vision makes sure that little fish do not get carried away 3How vision makes sure that little fish do not get carried away 4Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
... than 200 million people worldwide and is a ... Osteoporosis Foundation. Resistance training often is recommended to ... (BMD), although previous studies that examined the effects ... Now, in a new study, University of Missouri ...
... cells tighten their belts: they start to digest their ... as autophagy - takes place in special organelles called ... have developed as a means of survival when times ... has become a kind of self-cleaning process. In mammalian ...
... team at the Centre for Stem Cell Research in Cambridge ... http://dev.biologists.org/ ) a new and safer way of generating pluripotent ... to every tissue of the body. Rapid developments in stem ... stem cell scientists to convert specialised cells, such as skin ...
Cached Biology News:Building strong bones: Running may provide more benefits than resistance training, MU study finds 2Self-digestion as a means of survival 2Researchers piggyback to safer reprogrammed stem cells 2
(Date:1/15/2014)... , Jan. 15, 2014  Bill Jacobs Automotive, a group of ... teaming up with the Heartland Blood Center and offering free ... The drive takes place Saturday, Jan. 18 at the Bill ... p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The ...
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... antibody-drug conjugates for cancer, today announced the appointment of Thomas ... Reynolds has over 20 years, development experience gained in the ... Genetics. "I am delighted to welcome Tom at ...
(Date:1/15/2014)... Reston, VA (PRWEB) January 15, 2014 ... education have continued their sponsorship of an annual competition ... interest in, and access to, innovative STEM study. The ... , TEAMS: Tests of Engineering Aptitude, Mathematics, and ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5
... 2011 Sangui enters commercialization phase / Initial ... State of Tamaulipas has issued an initial order of Hemo2Spray, ... wound debridement product Scabremove both registered by the Mexican authorities ... order of the wound spray and Sangui management is positive ...
... and myeloma are both malignant diseases that arise from ... lymph nodes and the bone marrow. Although considerable progress ... they remain a significant challenge for patients and their ... for lymphoma and myeloma will be presented today at ...
... Corp. (NASDAQ: BSTC ), a biopharmaceutical company ... ® in the U.S. and XIAPEX ® ... George Gould, Esq., to its Board of Directors effective ... of George M. Gould, LLC, and of counsel to ...
Cached Biology Technology:Mexican State of Tamaulipas Starts Training Doctors in Sangui Wound Management 2Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 2Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 3Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 4Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 5Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 6Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 7Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 8Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response 9BioSpecifics Technologies Corp. Announces Appointment of George Gould to Board of Directors 2BioSpecifics Technologies Corp. Announces Appointment of George Gould to Board of Directors 3BioSpecifics Technologies Corp. Announces Appointment of George Gould to Board of Directors 4
... The Jouan RC Maxi MB (for aqueous, ... vacuum concentrator/centrifugal evaporator systems respond to specific ... rapid and safe concentration of heat-labile samples. ... pumps, different of cold traps and a ...
... concentrator for efficient drying of small volumes ... system combines the SpeedVac™ Concentrator and chemically ... pump and rotor control, and dual timers ... time), makes the DNA120 indispensable in the ...
... Start up kit. Includes configured Laptop PC ... 1 MultiBlock satellite thermal Cycler (non-robotic). ... User friendly software. Store/track run data. ... lid. Outstanding uniformity. Advanced control ...
... Thermal Cycler is Thermo Electron's most advanced ... with easy to use sophisticated onboard software ... programming. Designed to offer performance, accuracy and ... a number of customer driven features built ...
Biology Products: