Navigation Links
Stem cells bring fast direct improvement, without differentiation, in acute renal failure

lization of several genomic and nongenomic cell-tagging techniques, the researchers were able to follow the stem cells as they circulated through the renal microcirculation of two different strains of rats used in the experiments. "Although we did not detect transdifferentiation events during the 72-hour period of observation, it is possible that cell transdifferentiation and integration may be important at later states of organ repair," the study noted.

The Utah team used MSC for several reasons, notably the fact that they can be harvested easily from bone marrow, isolated, grown in culture and genetically engineered. To test that MSC subsequently used in these studies retained their phenotype after being cultured, the researchers routinely tested whether their characteristic potential to differentiate into fat and bone cells was preserved.

The researchers conceded that it "is surprising that the very transient presence of MSC in the injured kidney, as we document, is sufficient to greatly ameliorate the course" of I/R ARF and also note that the rat model of ARF used in the study is "a suitable if somewhat imperfect model of the most common and the most treatment-resistant type of human ischemic ARF."

Next steps

* Current studies are investigating the collective and individual renoprotective capacity of cytokines temporarily released by MSC.

* Two clinical efforts are planned. First will be a compassionate study in Europe next year in patients with complicated bone marrow transplants, a setting where such stem cells already are approved for use. If successful, a compassionate-use study in patients with severe ARF and multiorgan failure will be designed, eventually leading to clinical trials.

* Though no adverse effects were seen in these experiments, long-term studies are needed to prove that no adverse effects occur after in vivo administration of adult MSC.

* Also to be determined is whether
'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
(Date:4/2/2015)... 2, 2015 According to preliminary ... to somewhat higher than 125 MSEK. This exceeds the ... 2014 that revenues for Q1 2015 would be in ... for Q4 2014. The operating result for the first ... complete interim report will as previously communicated be published ...
(Date:3/31/2015)... YORK , March 31, 2015   Guidepoint ... the launch of the Post-Surgical Pain Management TRACKER, part ... products tracking usage trends in the medical device and ... access to data including treatment volumes, market share, and ... the pain associated with joint surgery. The ...
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... critical security-authentication needs, today announced the beginning of shipments ... solution. The company, based in ... the three-day Connect:ID Expo, which began here today at ... said version 2.0 of its SDK boosts the accuracy ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... The National Physical Laboratory (NPL) is hosting a ... into ,Measuring the Impossible,. The conference runs until ... The Measuring the Impossible, Network (MINET) shares research ... ways to measure complex phenomena that are dependent ...
... PARIS, November 12 Oberthur Technologies ... solutions to the Identity,market - has obtained several common ... Electronic passports, Governmental,Multi-application cards and European Citizen Cards. , ... Module ID-One ePass version 2.1 is ...
... counter-terrorist strategies and highlighting new and developing technologies to ... NJIT on Nov. 14, 2009, from 8:30 a.m. to ... Chapter of the Marine Corps Reserve Association, has invited ... ranging from cyber-security to protecting transportation venues. , ...
Cached Biology News:Researchers gather in the UK to 'measure the impossible' 2Oberthur Technologies: Major Security Certifications for the Identity Product Range 2Oberthur Technologies: Major Security Certifications for the Identity Product Range 3
(Date:4/17/2015)... April 17, 2015  US-Australian drug discovery company, Novogen, ... of Understanding with the Feinstein Institute for Medical ... to collaborate with the objective of ... The collaboration brings together the drug discovery expertise ... of the Feinstein Institute in neurosciences and oncology. ...
(Date:4/16/2015)... Carolina (PRWEB) April 17, 2015 ... steam system services, released their newly designed, state-of-the-art ... The customer facing website effectively promotes the Spirax ... , All the information that a site visitor ... system services, company capabilities, industries serviced, the latest ...
(Date:4/16/2015)... FL (PRWEB) April 16, 2015 ... cap distribution and physician network in Europe and ... company has appointed Fernando Bermúdez, former Business Development ... , An industry veteran, Mr. Bermúdez’s professional achievements ... 75% in Spain, while also penetrating the Portuguese ...
(Date:4/16/2015)... Ohio (PRWEB) April 16, 2015 ... Index, overexertion involving an outside source was ranked ... This includes injuries related to lifting, pushing, pulling, ... billion in direct costs. The David Round Company ... is committed to working hard to develop and ...
Breaking Biology Technology:Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6Spirax Sarco website has a new look 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... Silence Therapeutics plc (AIM: SLN) ("Silence" ... (RNAi) therapeutics company, today announces that application has been sought ... Shares") to be admitted to trading on AIM. The new ... agreement with Dr. Philip Haworth, former Chief Executive Officer of ...
... computational tasks -- may have applications in areas outside ... researcher and his collaborators. Working at the interface ... in Pitt,s Department of Physics and Astronomy in the ... his colleagues report their findings in a paper published ...
... Dec. 19, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: ... largest umbilical cord blood banking operator in China, today announced ... held on December 19, 2011, in Hong Kong. ... Ms. Ting Zheng and Dr. Yungang (Ken) Lu to serve ...
Cached Biology Technology:Silence Therapeutics Additional Listing 2Silence Therapeutics Additional Listing 3Quantum computing has applications in magnetic imaging, say Pitt researchers 2China Cord Blood Corporation Announces Results of 2011 Annual General Meeting 2
... Many modifications of Eagle's medium ... original formulation. The most widely ... Eagle's,Medium. DME is a modification ... [MEM] that contains a higher ...
... fixative useful for routine procedures. Hollandes contains ... and will decalcify small bone specimens. Tissue ... stained successfully with most stains, and the ... blood cell membranes and cosinophil and endocrine ...
... Shimadzus GCMS-QP2010s Gas Chromatograph/Mass Spectrometer, ... of the GCMS-QP2010 Plus, offers high ... with an excellent performance-to-cost ratio. Like ... patented constant linear velocity for optimum ...
... uniquely combines a single-channel sample processing head, ... bulk reagent dispenser all in one compact, ... disposable pipette tips, the Precision XS autoclavable ... is available for transferring larger volumes. Intuitive ...
Biology Products: