Navigation Links
Stem cells bring fast direct improvement, without differentiation, in acute renal failure

Acute renal failure, or ARF, is as serious as it sounds. An estimated 40% of critical care hospital admissions experience ARF. Estimates of their death rate range from 50% to 80%, complicated by the fact that patients with ARF often simultaneously suffer failure of other major organ systems.

The most serious form of ARF is caused by ischemia, or loss of blood supply to the kidneys caused by shock, blood infection or major cardiovascular surgery, particularly in such high- risk patients as those with diabetes, underlying renal disease, and the elderly. In the kidneys, such "insults" lead to destruction of kidney tubular and vascular cells, initiating a significant inflammatory response. Recovery of kidney function that is adequate for patient survival depends primarily on the protection and regeneration of destroyed and injured cells.

Yet virtually no progress has been made toward development of any highly effective ARF therapy for decades. "Basically, catastrophic loss of kidney function has remained treatment-resistant despite dialysis and intensive care. Treating patients with ARF thus presents a major clinical dilemma, particularly when severe ARF occurs with multiple organ failure," Christof Westenfelder from the University of Utah explained. "Our laboratory has therefore been pursuing development of novel therapeutic interventions that are urgently needed to treat this common, devastating and costly human disease," Westenfelder said.

Challenging the accepted theory of stem cell operation

In a new study, Westenfelder's team reported that injecting stem cells similar to the type used in bone marrow transplants is "highly renoprotective, showing almost immediate improvement in both kidney function and degree of tissue injury, followed by accelerated regeneration and return of function," he said. Furthermore, "these beneficial effects are predominantly mediated, as our data suggest, by paracrine rather than transdifferentiation-depend
'"/>

Source:American Physiological Society


Page: 1 2 3 4 5

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... Mary,s Virginia Institute of Marine Science have received ... Agency to identify the streams and wetlands most ... to help local governments and citizens conserve these ... a dataset of tidal-marsh observations first gathered by ... historical baseline can today,s researchers accurately map the ...
(Date:10/16/2014)... challenged conventional thinking on how the bowel lining develops ... how bowel cancer starts. , The researchers produced evidence ... the ,crypts, that are a feature of the bowel ... bowel cancer development, a controversial finding as scientists are ... 3D imaging technologies, Dr Chin Wee Tan and Professor ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... experiences trauma or disease, such as muscular dystrophy, ... cells" respond to repair and regenerate the muscle. ... such as muscular dystrophy, which affect muscle stability ... used time-lapse photography to document satellite cell movements ...
... PHILADELPHIA Although acute myeloid leukemia (AML) is relatively ... the risk, according to a recent paper published in ... of the American Association for Cancer Research. Julie ... and clinical research at the University of Minnesota, said ...
... to the poles, and you,ll notice that the ... equator. Move from lowland to mountains, and you,ll ... varied. Ecologists have proposed various explanations for these ... processes. New findings by University of ...
Cached Biology News:Caught on tape: Muscle stem cells captured on video by MU researcher 2Climate change and mountain building led to mammal diversity patterns 2
(Date:10/25/2014)... The Workgroup for Electronic ... authority on the use of health IT to ... appointment of four new co-chairs to the organization’s ... ,     Peter Dumont, Senior Director – ... Leader, Deloitte Consulting LLP ,     Deidre Rodriguez, ...
(Date:10/25/2014)... 2014 Today, Nerium International, a leader ... of its “Reflect Your Youth” contest, an effort launched ... a difference in their skin since using Nerium’s product ... on life as a result of their newfound confidence. ... effort by Nerium International to inspire conversations focused on ...
(Date:10/25/2014)... A new way to produce engineered skin not ... grafting technologies, it also speeds up the healing process, ... the October issue of STEM CELLS Translational Medicine, could ... result from severe burns and chronic wounds. , A ... These wounds heal by contraction, with epithelization (the process ...
(Date:10/25/2014)... -- Oramed Pharmaceuticals Inc. (NASDAQCM: ORMP) ( ... development of oral drug delivery systems, announced today that ... at FireRock Capital,s Micro-Cap Conference. Presentation ... October 28, 2014 ,Time: 9:15am EST ,Location: The Spring ... , About The FireRock Conference  ...
Breaking Biology Technology:WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2Nerium International™ Inspires Conversation About the Journey of Aging with “Reflect Your Youth” Contest 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3
... in a hexagonal, chicken wire structure holds great ... conductive, graphene may one day replace conventional silicon microchips, ... In addition to potential applications in integrated circuits, solar ... material has attracted the attention of physicists for its ...
... Inc. (NYSE Amex: NBS ), an international biopharmaceutical company ... will present on a panel at the 31st Annual Cowen Group ... March 7, 2011 at 1 PM and Dr. Robin Smith, the ... at 10:15 AM. The Conference will be held at the Boston ...
... Corporation (Nasdaq: VOLC ), a leading developer ... enhance the diagnosis and treatment of coronary and peripheral ... market the Eagle Eye® Platinum digital IVUS catheter in ... PCI Live Demonstration Course in Kurashiki, which starts on ...
Cached Biology Technology:Probing atomic chicken wire 2Probing atomic chicken wire 3Probing atomic chicken wire 4NeoStem to Present at Cowen Group 31st Annual Health Care Conference on March 7 and 8 2NeoStem to Present at Cowen Group 31st Annual Health Care Conference on March 7 and 8 3Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki 2Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki 3
Recommended for supporting the growth of anchorage-dependent cells including human and mouse stromal cells, mesenchymal cells and cell lines....
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: cap, ...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... General description: Workstation for PCR set-up ... 96 MicroWell format to hold 0.2 ml PCR tubes, ... compatible with automated handling systems Removable tray ... Compatible with V-bottom 0.2 ml tube block thermal ...
Biology Products: