Navigation Links
Stem cell therapy successfully treats heart attack in animals

Final results of a study conducted at Johns Hopkins show that stem cell therapy can be used effectively to treat heart attacks, or myocardial infarction, in pigs. In just two months, stem cells harvested from another pig's bone marrow and injected into the animal's damaged heart restored heart function and repaired damaged heart muscle by 50 percent to 75 percent.

The Hopkins findings, first presented last fall at the 2004 Scientific Sessions of the American Heart Association, are to be published in the latest issue of the Proceedings of the National Academy of Sciences online the week of July 25.

Two patients have already been enrolled at Hopkins in a Phase I clinical trial, which is designed to test the safety of injecting adult stem cells at varying doses in patients who have recently suffered a heart attack. In total, 48 patients will participate in this study, which is happening at several sites across the country. Results are not expected until mid-2006.

"Ultimately, the goal is to develop a widely applicable treatment to repair and reverse the damage done to heart muscle that has been infarcted, or destroyed, after losing its blood supply," says cardiologist Joshua Hare, M.D., professor of medicine at The Johns Hopkins University School of Medicine and its Heart Institute, and senior author of the study and lead trial investigator.

"There is reason for optimism about these findings, possibly leading to a first-ever cure for heart attack in humans," he says. "If a treatment can be found for the damage done by a heart attack to heart muscle, then there is the potential to forestall the serious complications that traditionally result from a heart attack, including disturbances of heart rhythm that can lead to sudden cardiac death, and decreased muscle pumping function that can lead to congestive heart failure."

The researchers are using a special kind of stem cell in an early stage of development, called adult mesenchymal s tem cells, to avoid potential problems with immunosuppression, in which every human's immune system might attack stem cells from sources other than itself. Bone marrow adult stem cells do not have the same potential to develop into different organ tissues, as do embryonic stem cells, whose use is more controversial.


'"/>

Source:John Hopkins Medicine


Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New therapy for HIV/AIDS eliminates needles and excessive toxicity
9. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
10. Gene therapy for Parkinsons disease moves forward in animals
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... NY (PRWEB) , ... August 14, 2017 , ... ... Clinical Trials event, which will take place on September 6, 2017 at the ... Karlin, MD , Head of Experimental Medicine, Informatics, and Regulatory Strategy, Pfizer Innovative Research ...
(Date:8/11/2017)... ... August 11, 2017 , ... Algenist continues to disrupt ... unlocking collagen like never before. , Collagen is the key structural element skin ... with Liquid Collagen™, which include: , First to market ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... week-- as students. From August 14th through the 16th, the University City Science ... in the summer of 2016, provides Philadelphia-based middle school educators an opportunity for ...
(Date:8/10/2017)... Grand Bahama (PRWEB) , ... August 09, 2017 , ... ... will take place at the Pelican Bay Hotel in Freeport, Grand Bahama on ... and pre-registration is required. , With oversight from the Ministry of Health’s National ...
Breaking Biology Technology: