Navigation Links
Stem cell microenvironment reverses malignant melanoma

Northwestern University researchers have demonstrated how the microenvironments of two human embryonic stem cell (hESC) lines (federally approved) induced metastatic melanoma cells to revert to a normal, skin cell-like type with the ability to form colonies similar to hESCs. The researchers also showed that these melanoma cells were less invasive following culture on the microenvironments of hESCs.

"Our observations highlight the potential utility of isolating the factors within the hESC microenvironment responsible for influencing tumor cell fate and reversing the cancerous properties of metastatic tumor cells, such as melanoma," said Mary J. C. Hendrix, in whose laboratories at Children's Memorial Research Center the experiments were conducted.

An article describing the findings by Hendrix and her laboratory group was published in the Nov. 17 online issue of the journal Stem Cells. Hendrix is president and scientific director of the Children's Memorial Research Center at Northwestern University Feinberg School of Medicine and a member of the executive committees of The Robert H. Lurie Comprehensive Cancer Center and the Center for Genetic Medicine at Northwestern University. The Northwestern researchers used a unique, three-dimensional model to test whether the microenvironment supporting human embryonic stem cells (hESCs) would influence the behavior of human metastatic melanoma cells ?since hESCs have the ability to develop into a variety of normal cell types ?to assume a more normal melanocyte-like cell, the skin cell type of origin for melanoma.

The model, which was developed in Hendrix's laboratories, consists of a three-dimensional collagen matrix preconditioned by hESCs, followed by their removal and subsequent application, or seeding, of metastatic melanoma cells onto the embryonic microenvironment, which was followed by molecular and functional analyses.

The team applied two different hESC lines, independently, onto three-
'"/>

Source:Northwestern University


Page: 1 2

Related biology news :

1. Stem cell identity in culture may strongly depend on the cellular microenvironment
2. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
3. Genetic therapy reverses nervous system damage in animal model of inherited human disease
4. Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy
5. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
6. Changing length of days reverses how estrogen affects aggressiveness in mice
7. Newfound roadblock to interferon effectiveness against malignant melanoma
8. Researchers discover why melanoma is so malignant
9. Possible birthplace of malignant brain tumors identified
10. Researchers test new therapy for advanced melanoma
11. Researchers use trickery to create immune response against melanoma

Post Your Comments:
(Date:11/20/2009)...s., November 19, 2009 The estimated 4.6 million A... risk of developing respiratory symptoms due to po...tionnaire study undertaken earlier this year by in...of Veterinary Medicine. , The studywhich polled ...hat 50 percent of individuals working in barns com...
(Date:11/20/2009)...vailable in German . , In the current onlin..., Dr. Stefanie Eyerich and Dr. Kilian Eyerich toge...ondon and Istituto Dermopatico dell,Immacolata in ...epresents a milestone on the way to developing new...such as psoriasis and allergic reactions and poten...
(Date:11/20/2009)...n a new study, researchers report that a class of ...helpful, or harmful, effect on the heart, dependin...h appears in the journal Circulation Research , f...- and beta-receptors on the heart muscle offer the...t target only the beta-receptors can actually unde...
Breaking Biology News(10 mins):Barn personnel experience higher-than-average rates of respiratory symptoms 2Discovery of new type of immune cells regulating inflammation in chronic diseases 2Carvedilol shown to have unique characteristics among beta blockers 2Any Day OK for Heart Bypass Surgery 58127 1Any Day OK for Heart Bypass Surgery 58127 2University of Hawaii Maui Community College Selects American TeleCare for Allied Health Department 26apos 3Bs Nursing Telehealth Project 58122 1University of Hawaii Maui Community College Selects American TeleCare for Allied Health Department 26apos 3Bs Nursing Telehealth Project 58122 2University of Hawaii Maui Community College Selects American TeleCare for Allied Health Department 26apos 3Bs Nursing Telehealth Project 58122 3PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 14223 1PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 14223 2PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 14223 3PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 14223 4PAREXEL Consulting Releases New Study Data on Drug Development Timelines in Safety First Era 14223 5
... The definition of conservation priorities for bi...rtebrate animals and seed plants in the northern h...ther organisms, and the more extreme regions of th...lants and mammals is low" An interdisciplinary tea...nd philosophers explored the worlds southernmost f...
... Washington, D.C. October 24, 2007 - The U.S. Se...d Education Appropriations Bill (S.1710), includin... of Health (NIH) to strengthen its Public Access P...ation by researchers. The bill will now be reconci...ains a similar provision, in another step toward s...
... WORCESTER, Mass. As the HIV/AIDS epidemic conti... million lives and infecting over 39 million, rese...roved treatments for those suffering with this dis...ng 15 to 59 year olds, AIDS is a remarkably resili...pidly. This evolution dramatically complicates tre...
Other Biology News:The conservation lens 2The conservation lens 3Mandate for public access to NIH-funded research poised to become law 2UMass Medical School researchers receive $8.5M grant award to fight AIDS 2UMass Medical School researchers receive $8.5M grant award to fight AIDS 3
(Date:11/19/2009).../ - Aegera Therapeutics Inc. announced today the d...B study of AEG35156, a targeted antisense therapeu... indications. ,, The study, entitled "An Open-L...bitor of Apoptosis (XIAP) Antisense AEG35156 Given...ubicin in AML Following Failure of a Single Standa...
(Date:11/19/2009)...ne Synthesis Companies Form International Gene Syn...ces in Risk Reduction ,Five Member Companies Rep...city , (PRWEB) November 1...synthesis companies today announced agreement that...omote biosecurity in the gene synthesis industry. ...
(Date:11/19/2009)...mber 19 AFFiRiS AG will focus its,...te at an unexpectedly early,stage of development: ...o,Phase II clinical trial early in 2010. This deci...tion of two Phase I trials with the candidates,AD0... the first interim,analysis of the secondary endpo...
(Date:11/18/2009)... Standards and Technology (NIST) has demonstrated ...ing and measuring elusive hazards such as conceale...d or pesticides distributed in soil by wind and ra...nventional techniques for detecting traces of thes...having distinct electrically positive and negative...
Breaking Biology Technology:Aegera Therapeutics Initiates a Randomized Phase 2B Study with AEG35156 for the Treatment of Acute Myeloid Leukemia (AML) 2World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 2World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 3World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol 4AFFiRiS AG: Interim Analysis of Clinical Phase I Data Triggered Decision to Move Alzheimer's Vaccine Candidate AD02 into Clinical Phase II Testing 2AFFiRiS AG: Interim Analysis of Clinical Phase I Data Triggered Decision to Move Alzheimer's Vaccine Candidate AD02 into Clinical Phase II Testing 3Prototype NIST method detects and measures elusive hazards 2
...ader in,at-home diagnostic sleep testing and sleep...ved version of its main web site,( http://www.slee...ity of,patients, family members, and healthcare pr... sleep testing and sleep apnea,treatment, we have ...xpanding patient population," said Robert Koenigsb...
.... (Nasdaq: BFRM ) today announced that Steven Bas...y overview at the upcoming 26th Annual,JPMorgan He...2008. BioForm,Medical,s presentation will take pla...11:30 am EST) at the Westin St. Francis Hotel in S... webcast of BioForm Medical,s,presentation will be...
...earlier treatment could ...ntists working at the,Hepatitis B Foundation, in p...ine, think they may have discovered a reliable alt...f liver fibrosis and cirrhosis, which,afflict more... and C,infections, as well as fatty liver diseases...
Other Biology Technology:SleepQuest Launches Updated Web Site 2BioForm Medical to Present at the 2008 JPMorgan Healthcare Conference on January 7, 2008 2Possible New Way to Detect, Monitor Liver Disease Without Painful Liver Biopsy 2
QuantiGene Plex Reagent Set for Animal/Plant Tissue from Panomics
Rabbit Anti-Occludin, C-Terminus Monoclonal Antibody, GST Conjugated, Clone PADZMD.544 from Invitrogen
Mouse Anti-JNK2 Antibody, Unconjugated from Upstate
ProtoArray Kinase Substrate Identification Application Kit from Invitrogen
Biology Products: