Navigation Links
Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors

Researchers at Duke University Medical Center have discovered the presence of stem cells in the cerebellum, a brain region where a deadly type of brain tumor originates. Their findings suggest that such tumors, called medulloblastomas, could arise from stem cells gone awry.

The cerebellum is the brain's control center for motor coordination and cognitive function, yet little has been known about the origins of the neurons and supporting "glial" cells that populate this region.

The Duke discovery of stem cells in the cerebellum suggests a possible origin for these normal cells and provides a starting point for understanding the basis of medulloblastoma, the most common malignant brain tumor in children, said the researchers.

Medulloblastomas arise in the cerebellum but their cells of origin have remained unclear. However, a number of these tumors have been shown to contain proteins that are normally found on neural stem cells. This finding perplexed scientists, as stem cells had never been shown to exist in the cerebellum.

The Duke study provides the first evidence that stem cells actually exist in the cerebellum and supports the theory that medulloblastomas could arise from these cells, said the researchers. They hope their discovery will eventually lead to more targeted, less toxic treatments that disrupt the process by which stem cells could give rise to brain tumors.

Their results are published in the June, 2005 issue of Nature Neuroscience. The study was funded by the Sidney Kimmel Foundation for Cancer Research, the James S. McDonnell Foundation and the National Institute of Mental Health.

"Some medulloblastomas are believed to arise from a type of cell called a granule cell," said Robert Wechsler-Reya, Ph.D., Assistant Professor of Pharmacology and Cancer Biology and senior author on the study. "However, the majority of medulloblastomas have no clear cell of origin. Our discovery demonstrates for the first time th
'"/>

Source:Duke Health


Page: 1 2 3

Related biology news :

1. Jump-starting T Cells In Skin Cancer
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
5. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Placenta Is A Rich Source Of Blood Stem Cells
8. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
9. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
10. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
(Date:7/28/2014)... New research has identified areas of the Earth that ... climate change. , Europe is particularly vulnerable, as it ... four per cent, of any continent in ,refugia, ... natural environmental conditions remain relatively constant during times of ... Europe are mostly in Scandinavia and Scotland. , ...
(Date:7/28/2014)... MANHATTAN, Kansas He calls himself the bug hunter, ... that can only be found and identified with special ... at the Kansas State Veterinary Diagnostic Laboratory at Kansas ... his discoveries, porcine enterovirus G, which is an important ... a virus in cells, but didn,t know what it ...
(Date:7/28/2014)... Jude Children,s Research Hospital study found that 73 percent ... their risk of developing metabolic syndrome and related health ... results appear in the current issue of the journal ... 1,598 adult survivors of childhood cancer in the study ... factors like high blood pressure, abdominal obesity, elevated triglyceride ...
Breaking Biology News(10 mins):Study finds Europe's habitat and wildlife is vulnerable to climate change 2Researcher using next-generation sequencing to rapidly identify pathogens 2Researcher using next-generation sequencing to rapidly identify pathogens 3Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3
... new gasoline. But where,s the nearest "gas" station ... vehicle? Will hydrogen stations be strategically convenientlocated on ... What marketing development obstacles need to be overcome if ... and gain widespread acceptance? According to an article ...
... the effect of nutrients on muscle maintenance in the hope ... we get old. The researchers, based at the School ... know what sort of exercise we can take and what ... of skeletal muscle with ageing. The team from the ...
... from Tel Aviv University, the saying may be more than ... have an ability to "see" colors and shapes with their ... of a new book, Advances in Information Optics and ... optical imaging technology that beats the limitations of today,s lens-based ...
Cached Biology News:The viability of hydrogen transportation markets: Chicken or egg? 2A stronger future for the elderly 2Seeing through the skin 2
(Date:7/28/2014)...   JOLT , a leading technology accelerator, announced today ... portfolio of startups. Next-level tech and boundary-pushing innovation have ... accelerator, and Cohort four is no exception, with six ... its launch in July 2012, JOLT has produced 17 ... at 23 investments, JOLT,s portfolio has an overall mix ...
(Date:7/28/2014)... 2014 According to ... (Consumables, Instruments, Services), Methods (Phenotypic, Genotypic), Applications (Pharmaceutical, Diagnostic, ... Characterization) - Global Forecasts to 2019" published ... estimated at $896.5 Million in 2014 and ... 2019, growing at a CAGR of 5.9% ...
(Date:7/28/2014)...  David Hardison, Ph.D., vice president of health ... been elected chairman of the board for the ... to establish common protocols around the use of ... electronic health records. Hardison will ... organizations across the research and health care arena ...
(Date:7/28/2014)... 28, 2014 Immunomic Therapeutics, Inc. (ITI) ... further develop potential treatments for glioblastoma multiforme (GBM), the ... with their patented vaccine platform, LAMP-vax. , The ... based on the work of John H. Sampson, MD, ... Preston Robert Tisch Brain Tumor Center at Duke University ...
Breaking Biology Technology:JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4
... Health Robotics today announced,audited results for FY2008 ending ... orders, revenue, earnings and cash flow. , ... million, a 161% increase year-over-year as,the company began ... indirect,sales-channel franchise fee model, recurring revenue recognition, zero ...
... MESA, Calif., April 14 Oxygen Biotherapeutics, ... it has reached a development and commercial ... One(R) Global Pharmaceutical Services business unit to ... perfluorocarbon (PFC) therapeutic oxygen carrier. Oxycyte will ...
... April 14 BioVex Inc, a company developing ... and infectious disease, announced today that its OPTiM (OncoVEX Pivotal ... previously treated patients with Stage III and Stage IV melanoma ... U.S. with sites in the United Kingdom, Germany and Australia ...
Cached Biology Technology:Health Robotics Reports Triple-Digit-Growth Across All Financial Metrics in Fiscal Year 2008 2Health Robotics Reports Triple-Digit-Growth Across All Financial Metrics in Fiscal Year 2008 3Health Robotics Reports Triple-Digit-Growth Across All Financial Metrics in Fiscal Year 2008 4Health Robotics Reports Triple-Digit-Growth Across All Financial Metrics in Fiscal Year 2008 5Oxygen Biotherapeutics, Inc. Signs Supply Agreement for Clinical-Grade Oxycyte for Clinical Trials and Future Needs 2BioVex Commences OncoVEX (GM-CSF) Phase 3 Trial in Metastatic Melanoma 2BioVex Commences OncoVEX (GM-CSF) Phase 3 Trial in Metastatic Melanoma 3BioVex Commences OncoVEX (GM-CSF) Phase 3 Trial in Metastatic Melanoma 4
... Fermentation System to achieve high ... and maximum information output 4 ... precision with small-scale requirements provides users ... with E.coli, Pichia pastoris, yeast, fungi ...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
... Antibody Binding: High, 400 ng IgG/cm ... , Binding Interaction: Hydrophobic/Ionic , Performance Certified: ... Flat , Maximum Well Volume: 360 µl ... ,Features, Special optically clear polystyrene ...
...
Biology Products: