Navigation Links
Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors

Researchers at Duke University Medical Center have discovered the presence of stem cells in the cerebellum, a brain region where a deadly type of brain tumor originates. Their findings suggest that such tumors, called medulloblastomas, could arise from stem cells gone awry.

The cerebellum is the brain's control center for motor coordination and cognitive function, yet little has been known about the origins of the neurons and supporting "glial" cells that populate this region.

The Duke discovery of stem cells in the cerebellum suggests a possible origin for these normal cells and provides a starting point for understanding the basis of medulloblastoma, the most common malignant brain tumor in children, said the researchers.

Medulloblastomas arise in the cerebellum but their cells of origin have remained unclear. However, a number of these tumors have been shown to contain proteins that are normally found on neural stem cells. This finding perplexed scientists, as stem cells had never been shown to exist in the cerebellum.

The Duke study provides the first evidence that stem cells actually exist in the cerebellum and supports the theory that medulloblastomas could arise from these cells, said the researchers. They hope their discovery will eventually lead to more targeted, less toxic treatments that disrupt the process by which stem cells could give rise to brain tumors.

Their results are published in the June, 2005 issue of Nature Neuroscience. The study was funded by the Sidney Kimmel Foundation for Cancer Research, the James S. McDonnell Foundation and the National Institute of Mental Health.

"Some medulloblastomas are believed to arise from a type of cell called a granule cell," said Robert Wechsler-Reya, Ph.D., Assistant Professor of Pharmacology and Cancer Biology and senior author on the study. "However, the majority of medulloblastomas have no clear cell of origin. Our discovery demonstrates for the first time th
'"/>

Source:Duke Health


Page: 1 2 3

Related biology news :

1. Jump-starting T Cells In Skin Cancer
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
5. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Placenta Is A Rich Source Of Blood Stem Cells
8. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
9. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
10. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
(Date:9/18/2014)... people are too stressed they are often grouchy, grumpy, ... Institute (BMI) at EPFL have just highlighted a fundamental ... and the loss of social skills and cognitive impairment. ... regulatory molecule in the brain. This was revealed by ... , Carmen Sandi,s team went to look for answers ...
(Date:9/18/2014)... Clownfish spend their entire lives nestling in the protective ... as babies they sometimes travel hundreds of kilometres across ... by reef fish has been predicted, this is the ... between distant populations has been observed. , Dr Steve ... at the University of Exeter, and colleagues from the ...
(Date:9/17/2014)... student have designed a device based on a shorebird,s ... dew., The device could provide water in drought-stricken areas ... Luo, professor in the Mechanical & Aerospace Engineering Department, ... of Engineering department, published "Bioinspired Plate-Based Fog Collectors" in ... Applied Materials & Interfaces journal. ...
Breaking Biology News(10 mins):How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Shorebird's beak inspires UT Arlington research on water collection 2
... 23andMe, the leading personal genetics company, announces the ... Neil Rothstein as Vice President Marketing, and Jonathan ... company,s executive leadership team. As ... the company,s corporate communications, media relations and investor ...
... Oct. 17, 2012 Rising crime rates and ... increase monitoring and introduce reliable border control systems. ... criminal identification and automated immigration at all entry ... adoption in the government vertical across Asia-Pacific. ...
... 24, 2012  Aware, Inc. (NASDAQ: AWRE ), ... assurance products, today reported financial results for its third ... our DSL service assurance hardware business have been reported ... the shutdown of that business during the third quarter. ...
Cached Biology News:23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions 2Increased Focus on Security Bolsters Growth of Biometrics Market in Asia-Pacific, Finds Frost & Sullivan 2Increased Focus on Security Bolsters Growth of Biometrics Market in Asia-Pacific, Finds Frost & Sullivan 3Increased Focus on Security Bolsters Growth of Biometrics Market in Asia-Pacific, Finds Frost & Sullivan 4Aware, Inc. Reports Third Quarter 2012 Financial Results 2Aware, Inc. Reports Third Quarter 2012 Financial Results 3Aware, Inc. Reports Third Quarter 2012 Financial Results 4Aware, Inc. Reports Third Quarter 2012 Financial Results 5Aware, Inc. Reports Third Quarter 2012 Financial Results 6
(Date:9/19/2014)... -- , The first grants awarded to ... (ESPE) Meeting  Investment supports innovative projects for ... field of growth  , EMD Serono, a ... , today announced the first recipients of the Grant ... announced during a Satellite Symposium organized by EMD Serono ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... September 18, 2014 ... http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the addition ... Global Strategic Business Report" report ... ,This report analyzes the worldwide markets ... by the following Product Segments: Polymeric ...
(Date:9/18/2014)... -- Research and Markets has announced ... Report 2014" report to their offering. ... is a professional and in-depth study on the ... The report provides a basic overview of ... chain structure. The N-acetylcysteine market analysis is provided ...
Breaking Biology Technology:EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2
... 14 LI-COR Biosciences introduces a,new, novel protein ... Imaging system. The Odyssey Two-Color Protein Molecular Weight,Marker ... 800 nm channels of the,Odyssey System. The marker ... be used to visualize the progress of protein ...
... National Drug Control Policy to Moderate ... Bad Drugs, FRAZER, Pa., Oct. 14 ... embarking on a national educational,program designed to promote ... the importance of appropriate and responsible use of,prescription ...
... ProtoKinetix (OTC,Bulletin Board: PKTX), a biotech ... of patented anti-aging glycopeptides,(AAGPs(TM)), announced today that ... a division of National Financial Communications Corp.,(NFC), ... "ProtoKinetix, AAGP(TM) platform technology is ideal ...
Cached Biology Technology:LI-COR Introduces the Odyssey(R) Two-Color NIR Fluorescent Protein Molecular Weight Marker 2Cephalon Launches National Consumer Awareness Initiative on Appropriate Use of Prescription Opioid Medications 2ProtoKinetix Partners with OTC Financial Network to Increase Shareholder Base 2ProtoKinetix Partners with OTC Financial Network to Increase Shareholder Base 3
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
... has a long and outstanding history ... Several years ago we became aware ... was being modified to inject Xenopus ... redesigning the microdispenser to eliminate any ...
...
... designed for sequencing inserts cloned into M13/pUC-based ... T3 RNA polymerase promoters, or lambda gt10 ... a concentration of 0.1 µg/µl in water. ... sequencing reactions using SequiTherm™ EXCEL™ II DNA ...
Biology Products: