Navigation Links
Statins have neutral effect on risk of cancer

The cholesterol-lowering medications called statins do not appear to reduce the incidence of cancer or cancer deaths, according to a meta-analysis of previous studies in the January 4 issue of JAMA.

Other studies have suggested that statins reduce the risk of developing cancer, the authors provide as background information in the review article. "Statins have been studied in numerous large-scale, randomized, active- or placebo-controlled trials for primary and secondary prevention of coronary artery disease. In these trials, statins reduced the risk of a first myocardial infarction (heart attack) and overall mortality. With long-term follow-up and collection of cancer data in a majority of studies, insight into the risk of cancer among statin-naïve persons and statin users can be derived," the authors write.

C. Michael White, Pharm.D., from the University of Connecticut and Hartford Hospital, Hartford, Conn., and colleagues, conducted a search of the medical literature from 1966 through July 2005 to identify randomized controlled trials of statins. They found 27 articles (n = 86,936 participants) that met their criteria for inclusion, reporting 26 randomized controlled trials of statins with data on either cancer incidence (n = 20 studies) or cancer death (n = 22 studies).

"In our current meta-analysis, statins did not reduce the incidence of cancer or cancer death," the authors report. "No reductions were noted for cancers of the breast, colon, gastrointestinal tract, prostate, respiratory tract, or skin (melanoma) when statins were used." The authors continue, "?the patients in our meta-analysis were primarily treated with simvastatin and pravastatin. As such, we evaluated pravastatin alone and simvastatin alone on cancer incidence and death and found no impact."

"Statins have a neutral effect on cancer and cancer death risks in randomized controlled trials," the authors write in conclusion. "We could find no type of c ancer that statins benefited or subtype of statin that reduced the risk of cancer.


'"/>

Source:JAMA and Archives Journals


Related biology news :

1. Statins stop hepatitis C virus from replicating
2. Defensins neutralize anthrax toxin
3. Bleach found to neutralize mold allergens
4. Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
5. Scientific issues associated with carbon-neutral energy sources such as cellulosic ethanol
6. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
7. Combination therapy boosts effectiveness of telomere-directed cancer cell death
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. Alcohols effects on gene expression in the central nervous system
10. Boosting HIV screening can increase survival and is cost effective
11. Liposome finding implies electrical effect on cell development
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Global demand for enzymes is ... 2020 to $7.2 billion.  This market includes enzymes ... products, biofuel production, animal feed, and other markets) ... biocatalysts). Food and beverages will remain the largest ... consumption of products containing enzymes in developing regions.  ...
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer experts ... they believe could be a new and helpful biomarker for malignant pleural mesothelioma. ... here to read it now. , Biomarkers are components in the blood, ...
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former senior ... the University of North Carolina Kenan-Flagler Business School effective June 27. ... Kenan-Flagler, with a focus on the school’s international efforts, leading classes and participating ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
Breaking Biology Technology: