Navigation Links
Staphylococcus aureus hides out in cells

A major cause of human and animal infections, Staphylococcus aureus bacteria may evade the immune system’s defences and dodge antibiotics by climbing into our cells and then lying low to avoid detection. New research in the online open access journal BMC Genomics shows how S. aureus makes itself at home in human lung cells for up to two weeks.

A team of 12 researchers from University Hospital of Geneva, Switzerland and the Institute of Food Research, Norwich, UK set out to uncover what S. aureus (6850) did inside human lung epithelial cells (A549) using an in vitro model. They found that shortly after S. aureus entered the lung cells, the bacteria’s gene expression profile dramatically changed: gene expression for bacterial metabolic functions and transport shut down, putting the bacteria in a dormant state. Simultaneously, production of toxins potentially lethal for the epithelial cells becomes strictly controlled to limit cellular damage. Mechanisms that helped the bacteria to survive and/or multiply, including metabolic and energy production functions, then resumed. Although most of the bacteria had died by about four days as a result of antibiotic treatment, the team still found viable bacteria in their model system two weeks after infection.

The findings may help in understanding persistent infections, and in designing new antibacterial drugs. S. aureus has not traditionally been considered an intracellular pathogen, but the molecular details that govern its extended persistence remain largely unknown. The bacteria can generate relapsing infections even years after the first episode was apparently cured.

“S. aureus intracellular survival appears related to its capability to adopt a discrete behaviour instead of actively duplicating,” says Patrice Francois, a Geneva-based member of the research team. “S. aureus then benefits from natural or programmed cell death to re-emerge and trigger another episode of infection, leading to chro nicity.”
'"/>

Source:BioMed Central


Related biology news :

1. Bedsores and bald hides: Novel roles revealed for a scaffolding protein
2. Resistant HIV quickly hides in infants cells
3. Wisconsin scientists grow critical nerve cells
4. Spleen may be source of versatile stem cells
5. Researchers discover way to make cells in the eye sensitive to light
6. Priming embryonic stem cells to fulfill their promise
7. Lack of enzyme turns fat cells into fat burners
8. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
9. Elusive HIV shape change revealed; Key clue to how virus infects cells
10. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
11. Enzyme allows B cells to resist death, leading to leukemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... 2016  There is much more to innovative access ... engine. Continental will demonstrate the intelligence of today,s solutions ... . Through the combination of the keyless entry and ... elements, the international technology company is opening up new ... "The integration of biometric elements brings our ...
(Date:12/8/2016)... PUNE, India , Dec. 8, 2016 Market Research ... and Service Market. The global Mobile Biometric Security and Service Market ... period 2016 to 2022. Market Highlights: ... , , ... fast pace due to the increasing need of authentication and security ...
(Date:12/7/2016)... , December 7, 2016 BioCatch , ... expansion of its patent portfolio, which grew to over 40 granted and ... , , ... recently filed patent entitled " System, Device, and Method Estimating ... that enables device makers to forego costly hardware components needed to estimate ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017  Northwell Health today announced ... of precision cancer research. As ... health care provider, Northwell Health diagnoses and treats ... is a Germany -based oncology ... Together they will greatly expand cancer biobanking activities ...
(Date:1/17/2017)... Hong Kong (PRWEB) , ... January 17, 2017 ... ... management software, and NetDimensions, a global provider of learning and performance management systems ... for the mainland China market. , “In the life sciences industry, organizations must ...
(Date:1/16/2017)... NY (PRWEB) , ... January 16, 2017 , ... ... New Jersey laws precedential publication its decision on the appeal filed by India-based ... lawsuit of breach of contract against DPCL and one of its Dishman Group’s ...
(Date:1/14/2017)... ... January 14, 2017 , ... Seattle-based ... complete end-to-end genome assemblies to researchers around the globe. Long considered a ... in answering a wide range of scientific questions. The announcement was made ...
Breaking Biology Technology: