Navigation Links
St. Jude projects 90 percent cure rate for ALL

patient to treatment," Pui said. "That information helps us to determine how intensive the rest of the therapy should be. Our goal is the complete eradication of leukemic cells with the least toxicity to the children."

The continued improvement in diagnosis and treatment made possible by MRD, pharmacogenomics and new drug therapies has shifted the focus in ALL therapy toward reduction of both the immediate and long-term side effects of treatment. For example, a St. Jude team lead by Evans demonstrated that patients who lack the enzyme TPMT are more sensitive to thiopurine chemotherapy drugs and are more likely to suffer damage to the body's blood-producing cells. Evans subsequently discovered the genetic cause and developed a gene-based test that permits clinicians to identify children who should be treated with lower doses of this class of drugs while still receiving full therapeutic benefit. The overall improvements have led to more skilled use of cancer drugs, stem cell transplantation and treatment of ALL that invades the central nervous system, according to Pui.

"We are now testing the feasibility of omitting irradiation for all patients and reserving this treatment for only those children who suffer a relapse," he noted. "Irradiation of the brain can cause second cancers, hormonal disturbances and disruption of intellectual development as the child grows. So our omission of the use of irradiation should further reduce acute and long-term toxic side effects and improve outcome."

Coupled with the successes of the recent past, future treatment improvements promise to continually improve the survival rate of ALL, Evans said. For example, new drugs directed against the proteins made by genes linked to ALL will add to the options for treating this disease.

"Multiple breakthroughs at St. Jude and elsewhere have transformed ALL from a virtual death sentence into a disease that children can increasingly be expected to survive with minima
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3 4 5

Related biology news :

1. Disease diagnosis, biodefense among UH chemical research projects
2. Hunger in America rises by 43 percent over last five years
3. Method slashes quantum dot costs by 80 percent
4. Hepatitis B accounts for 40 percent of missing Asian women
5. Vaccine provides 100 percent protection against avian flu virus in animal study
6. Oceans are 70 percent shark free
7. BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins
8. Biofuels can replace about 30 percent of fuel needs with significant research and policy effort
9. Psychotropic drug prescriptions for teens surge 250 percent over 7 year period
10. Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent
11. Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jude projects percent cure rate for ALL

(Date:8/1/2014)... elements are a key component of phloem, the conductive ... range of signalling molecules. Elongated cylindrical cells are capped ... end-to-end to form sieve tubes which in turn form ... "Sieve elements are very special cells which play an ... little has been known about their differentiation," says Professor ...
(Date:8/1/2014)... a more effective way to control the condition, thanks ... National University of Singapore (NUS). , The team, led ... Pharmacology at the NUS Yong Loo Lin School of ... PhD graduate from the Saw Swee Hock School of ... herbal-based anti-malarial drug, can be used to control asthma, ...
(Date:7/31/2014)... found to be a key gene responsible for hearing in ... cells of the inner ear that contracts and expands rapidly ... phonograph horn, amplify sound waves to make hearing more sensitivity. ... advanced online edition of Molecular Biology and Evolution , ... independently evolved to play a critical role in the ultrasonic ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2NUS study shows effectiveness of common anti-malarial drug in controlling asthma 2
... , A new fungal species, called , Hebelomagriseopruinatum , ... species. The fungus, whose name can be translated into ... Denmark during a mushroom-hunting tour headed by postdoc Jacob ... mushroom-hunting excursion in 2009, postdoc Jacob Heilman-Clausen from the ...
... 2012) -- In the face of mounting evidence that ... decision-making, biophysicists and cancer researchers at Rice University, Tel ... new strategy for outsmarting cancer through its own social ... that cancer is a random collection of cells running ...
... the United States and Sweden have discovered a new control ... the treatment of diabetes and other metabolic diseases. A-kinase anchoring ... of kinases within the cell, crucial enzymes that control important ... the blood. In a new study published in The ...
Cached Biology News:New Danish fungal species discovered 2Experts propose 'cyber war' on cancer 2Experts propose 'cyber war' on cancer 3Anchoring proteins influence glucose metabolism and insulin release 2
(Date:7/31/2014)... the British mathematician (1912-1954), is famous for a number ... century. In 1936 he published a paper, which laid ... concept of a computer algorithm. He next played a ... machines which cracked the German military codes, enabling the ... And in the late 1940,s he turned his attention ...
(Date:7/31/2014)... 31, 2014 According to a ... Dots Market - Global Industry Analysis, Size, Share, Growth, ... valued at USD 88.5 million in 2011, which is ... at a CAGR of 53.8% from 2013 to 2023. ... at  http://www.transparencymarketresearch.com/quantum-dots.html Increasing demand for energy ...
(Date:7/31/2014)... DUBLIN , July 31, 2014 ... the "Global Genomics Market 2014-2018" report to ... Genomics is the study of the genetic ... to be a strong basis for the discovery and ... of human diseases or health conditions. Genomics is supported ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Held at ... patients with an overview of the disease and its ... drug side effects, as well as updates on the ... to Dr. Sandy Srinivas for organizing this educational opportunity,” ... kidney cancer. “Sandy and her colleagues have put together ...
Breaking Biology Technology:A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... Madison, Wis. The Greater ... a web site linking local small ... business formation tips, government agencies, and ... the site to connect visitors with ...
... the fledgling Biomedical Technology Alliance (BTA) took a major ... Wisconsin Dept. of Commerce and another $500,000 in matching ... that showed the promise for formalizing pathways for collaboration ... example of the kind of cross-institutional partnerships that are ...
... Wisconsin Technology Network edition, we interviewed Barry Chaiken, chair of ... chief medical officer of BearingPoint. , , WTN: If ... about my information technology resources now? , , ... value from the money that I'm spending? Value is on ...
Cached Biology Technology:Alliance looks to create the right chemistry in SE Wisconsin 2Alliance looks to create the right chemistry in SE Wisconsin 3Interview: Dr. Barry Chaiken on healthcare IT 2Interview: Dr. Barry Chaiken on healthcare IT 3