Navigation Links
St. Jude announces breakthrough in eye cancer treatment

Scientists at St. Jude Children's Research Hospital have demonstrated in a mouse model a new, locally applied treatment for the eye cancer retinoblastoma that not only greatly reduces the size of the tumor, but does so without causing the side effects common with standard chemotherapy. The treatment also appears to be suitable for certain forms of breast, lung, prostate and colon cancer, and is simple enough for widespread use even in countries with limited resources.

A report on this work appears in the Nov. 2 issue of the journal Nature.

Retinoblastoma occurs in about 5,000 young children worldwide each year, arising from the immature retina, which is the part of the eye responsible for detecting light and color. The cancer is fatal if left untreated.

The new treatment holds promise for a simpler, more effective and less-toxic treatment for retinoblastoma that would eliminate the need for the current, complex therapy, according to senior author Michael Dyer, Ph.D., a Pew Scholar and associate member of the St. Jude Department of Developmental Neurobiology. The treatment is based on a discovery by Dyer's laboratory that overturned a widely held belief about the process of apoptosis (cell suicide) in retinoblastoma. Apoptosis is the way the body rids itself of abnormal cells that might become cancerous or cause other problems.

Until now, retinoblastoma experts thought that a mechanism called the p53 pathway triggered apoptosis in other types of cancer cells, but not in retinoblastoma. However, the St. Jude team proved not only that the p53 pathway was activated in early-stage retinoblastoma, but that excessive levels of a molecule called MDMX blocked it from triggering apoptosis in more advanced tumors. Based on this discovery, the St. Jude team used a molecule called nutlin-3 to block MDMX in retinoblastoma cells in test tube studies as well as in mouse models. The molecule was originally developed by

Roche Pharmaceuti
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3 4

Related biology news :

1. Wiley announces publication of Databasing the Brain
2. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
3. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
4. Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer
5. GlycoFi announces the first production of antibodies with human glycosylation in yeast
6. NHGRI announces new sequencing targets
7. CHAVI announces international search for genes affecting HIV response
8. NHGRI announces latest sequencing targets
9. MUHC announces a transplant first in Quebec
10. NIH announces phase III clinical trial of creatine for Parkinsons disease
11. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Jude announces breakthrough eye cancer treatment

(Date:8/27/2014)... abandoned each year in U.S. waters and become what ... fish, crabs, and other species such as turtles. These ... watermen who depend on the resources--losses that are largely ... The report, published in the Marine Pollution Bulletin ... the derelict fish trap problem, and so-called "ghost fishing," ...
(Date:8/27/2014)... A growing number of studies have shown ... the pathogenesis of Parkinson,s disease. Previous studies ... Medical University in China have shown that ... injury, reduced divalent metal transporter 1 expression, ... substantia nigra of rotenone-induced Parkinson,s disease rats. ...
(Date:8/27/2014)... University of Adelaide research has shown that piglets can ... birthing frequency. , The outcome of the study at ... Animal Reproduction Science , is an important finding for ... welfare without loss of production. , "Sows don,t usually ... on heat after their piglets have been weaned," says ...
Breaking Biology News(10 mins):NOAA's Marine Debris Program reports on the national issue of derelict fishing traps 2Piglet weaning age no bar to litter frequency 2
... be your response to a radiological incident? How will your State ... us? How do we even know if we are exposed to ... 42nd Midyear Topical Meeting of the Health Physics Society (HPS), which ... at the Henry B. Gonzales Convention Center. The topic is "Recent ...
... groups including the mentally ill, the disabled and ... fare worse than others in the aftermath of natural ... Now, a new study by UCLA researchers ... terrorism-related fears and make more behavioral changes based on ...
... month, the City of Newark, Delaware became the first ... to store and provide power for the local electric ... alone, is specifically designed to store energy and improve ... concept, called Vehicle-to-Grid (V2G). With the City of Newark,s ...
Cached Biology News:42nd Mid-year Topical Meeting of the Health Physics Society 2Disabled and other vulnerable groups more susceptible to terrorism fears 2City of Newark first in nation using cars to power grid 2
(Date:8/27/2014)... TX (PRWEB) August 27, 2014 The ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
(Date:8/27/2014)... , Aug. 27, 2014  A novel biomarker ... help physicians better identify early-stage disease, when treatment ... according to a new study in The Journal ... (NYSE: DGX ) and other institutions ... protein outperformed conventional antibody-serum testing, including rheumatoid factor ...
(Date:8/27/2014)... Flagship Biosciences LLC, a leading provider of ... and medical device industries, has announced a laboratory and ... has consolidated its histology and tissue analysis operations from ... just north of Denver. The new addresses are: ... Suite 100, Westminster, CO 80021 , Tissue Image Analysis ...
(Date:8/27/2014)... Aug. 27, 2014 Tris Pharma, a specialty ... today announced that it has been selected as an ... Association,s 2014 Awards for Excellence competition in ... independent panel of judges from SCORE (Counselors to America,s ... will be honored at a gala event to be ...
Breaking Biology Technology:Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Flagship Biosciences Announces Relocation and Expansion 2Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2
... , ... throughout all industries, which were once inspected with vision and or touch-probe, will now ... critical to batch production with tight tolerance levels which can now be easily monitored ... ...
... ... recruitment strategies. CenterWatch discusses tips to leverage online resources to enhance patient recruitment rates at ... ... study volunteers, the Internet is rated as one of the top ways patients learn about ...
... Md. , Jan. 12 Novavax, Inc. (Nasdaq: ... a pre-clinical safety and efficacy study of its RSV vaccine ... to support an Investigational New Drug (IND) application to advance ... candidate into clinical development.  This vaccine candidate is composed of ...
Cached Biology Technology:Nanometer Online Inspection With Nanovea 3D Non-Contact Profilometer 2CenterWatch to Address Importance of Web Use to Boost Patient Recruitment Rates 2CenterWatch to Address Importance of Web Use to Boost Patient Recruitment Rates 3NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 2NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 3NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 4NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate 5
... in Tris buffer, pH 10.2 give activity ... system. Assays in diethanolamine buffer, pH 9.8 ... glycine buffer system. Protein determined by Biuret ... salts Preparation Unit Definition: One unit will ...
... traps a wide variety of solvent vapors that can ... flask (GCF400) allows for the collection of liquid into ... time minimizes waiting period., Ultra low -104 ... , Digital Display of ...
... Trap is specifically designed for efficient ... as DMSO and DMF in the ... refrigeration system set at -5 o ... DMSO, while completely eliminating the risk ...
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
Biology Products: