Navigation Links
Spinal cord bridge bypasses injury to restore mobility

The body's spinal cord is like a super highway of nerves. When an injury occurs, the body's policing defenses put up a roadblock in the form of a scar to prevent further injury, but it stops all neural traffic from moving forward.

Researchers from Case Western Reserve University, Drexel University and the University of Arkansas bypassed this roadblock in the spinal cord. First, the researchers regenerated the severed nerve fibers, also called axons, around the initial large lesion with a segment of peripheral nerve taken from the leg of the same animal that suffered the spinal injury. Next, they jump started neural traffic by allowing many nerve fibers to exit from the end of the bridge. This was accomplished, for the first time, by using an enzyme that stopped growth inhibitory molecules from forming in the small scar that forms at the exit ramp of the bridge, where it is inserted into the spinal cord on the other side of the lesion. This allowed the growing axons to reconnect with the spinal cord.

Jerry Silver, a professor of neurosciences at the Case School of Medicine, was senior author among the researchers reporting in the Journal of Neuroscience article, "Combining an Autologous Peripheral Nervous System 'Bridge' and Matrix Modification by Chondroitinase Allows Robust Functional Regeneration beyond a Hemisection Lesion of the Adult Rat Spinal Cord." The other researchers were John Houle, the lead author, and Veronica Tom (a Case alum) from Drexel University College of Medicine; and Gail Wagoner and Napoleon Phillips from the University of Arkansas.

The researchers employed a combination of two strategies--one old and one new--in efforts to regenerate nerves in the spinal cord and restore movement, said Silver.

For more than 100 years, researchers have used grafts of peripheral nerves from the rib area or parts of the leg. While peripheral nerves can be used successfully as grafts in the limbs, spinal cord injuries
'"/>

Source:Case Western Reserve University


Page: 1 2 3

Related biology news :

1. 3D Atlas Will Help Navigate The Spinal Cord
2. By creating molecular bridge, scientists change function of a protein
3. Grid bridges 4,800 miles for molecular repositories
4. Terror bird arrived in North America before land bridge, study finds
5. UNC launches study of liver injury caused by drugs
6. Brain-injury rehabilitation depends on acetylcholine circuitry
7. Stem cell treatment improves mobility after spinal cord injury
8. Combination therapy leads to partial recovery from spinal cord injury in rats
9. Study reveals genomics of inflammation from severe injury
10. Clinical trial to test stem cell approach for children with brain injury
11. Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Spinal cord bridge bypasses injury restore mobility

(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
(Date:3/20/2015)... , Mar. 20, 2015 Research and Markets ... addition of the "India Sensors Market Forecast ... The sensor market is projected to ... Consumer electronics, automotive, industrial and healthcare ... in the country. In addition, adoption of MEMS ...
(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Biometrics - Global Strategic Business Report" report to their ... Iris Biometrics in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Latin America . Annual ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... that the extremely hot, dry and windy conditions on Black ... rolls, -similar to streamers of wind flowing through the air ... the first of its kind to produce such detailed, high-resolution ... for future fire management and warning systems. The work ...
... is a project that will require the cooperation ... and individuals. The 2012 American Chestnut Summit will ... and industry professionals to share the current state ... reintroduction of this species to eastern forests. The ...
... New Rochelle, NY, August 7, 2012The global market value of ... once therapeutics are approved that actually change the course of ... (GEN). The current therapeutic market is valued at $3 to ... or address the symptoms but do not alter the underlying ...
Cached Biology News:Unusual weather events identified during the Black Saturday bushfires 2GEN reports on recent progress in Alzheimer's research 2
(Date:5/1/2015)... , May 1, 2015 Albany Molecular ... William S. Marth , AMRI,s President and Chief ... Merrill Lynch 2015 Health Care Conference on Wednesday, May ... live audio webcast of the presentation can be accessed ... The webcast will be archived for ...
(Date:5/1/2015)... and RESEARCH TRIANGLE PARK, N.C. ... UTHR ) announced today that Roger Jeffs , Ph.D., ... an overview and update on the company,s business at the ... Boston, Massachusetts . The presentation ... PM Eastern Time, and can be accessed via a live ...
(Date:4/30/2015)... April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... advanced testing solutions for the detection of foodborne pathogens, ... first quarter of 2015 on May 7, 2015 after ... Bioscience will also host a conference call at 4:30 ... its first quarter financial results. During the conference call, ...
(Date:4/30/2015)... San Francisco, CA (PRWEB) April 30, 2015 ... for the first quarter of 2015 were $4.4 million, compared ... The net loss for the first quarter was $8.9 million, ... to a net loss for the same period in 2014, ... share. As of March 31, 2015, cash, cash equivalents and ...
Breaking Biology Technology:AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 2Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 3Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 4Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 5Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 6Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 7Cytokinetics, Incorporated Reports First Quarter 2015 Financial Results 8
... MOUNTAIN VIEW, Calif., Feb. 17 Frost & Sullivan, ... is,regaining its strength, thanks in part to an unprecedented ... additional stimulus packages from,foreign governments. , ... "President Obama,s stimulus package is clearly serving ...
... Warwick have found that tiny nanoparticles could be twice ... non mixing liquids than previously believed. This opens ... of nanoparticles in living cells, polymer composites, and ... working on ways of further artificially enhancing this new ...
... LLC, a wholly owned subsidiary of The Dow Chemical ... Rice Research Institute (CNRRI) of Hangzhou,China, announced today that ... strengths of Dow AgroSciences, platform of traits and technologies,with ... "We look forward to working with CNRRI to introduce ...
Cached Biology Technology:Frost & Sullivan Forecasts Early Rebound: Strong Growth Ahead for Global Economy 2Nanoparticles double their chances of getting into sticky situations 2Dow AgroSciences, China National Rice Research Institute Announce Collaboration on Rice Research 2