Navigation Links
Sperm stem cells closer to being like embryonic stem cells

New experiments that prevented rat sperm stem cells from changing permanently into sperm have brought researchers one step closer to coaxing such cells to behave like embryonic stem cells, capable of growing into many other types of cells in the body.

Researchers at the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center devised methods to keep male rat germ-line stem cells ?sperm precursor cells ?from differentiating, or changing, into sperm proper. The researchers also froze the sperm stem cells, thawed them, and transplanted them back into rat testes, where they developed into normal sperm.

Dr. David Garbers, professor of pharmacology, director of the Green Center and senior author of a study appearing in an upcoming issue of the Proceedings of the National Academy of Sciences, said the new work has many potential applications, including a possible alternative to embryonic stem cells, the development of new male contraceptives and new animal models to test stem cell-based therapies. Germ-line cells are those such as egg and sperm and their precursors whose genetic material can be passed to offspring.

"The ability to manipulate male germ-line stem cells and get them to grow and self-renew is a major step," said Dr. Garbers, a Howard Hughes Medical Institute investigator at UT Southwestern.

"We're only one step removed from another major step, the Holy Grail for us certainly, which is pushing these cells back a level to a state that is pluripotent-like, similar to embryonic stem cells. That's what we're focused on now."

Pluripotent cells have the potential to change into many other types of cells in the body, such as liver cells and brain cells. Their potential use in humans to treat diseases like diabetes and Parkinson's is controversial because currently the only source of such cells for research is human embryos or mouse cells. Recently another research team published results
'"/>

Source:UT Southwestern Medical Center


Page: 1 2 3

Related biology news :

1. Sperm trading can resolve hermaphrodite mating conflicts
2. Sperm created in the laboratory from embryonic stem cells produce viable progeny
3. Wisconsin scientists grow critical nerve cells
4. Spleen may be source of versatile stem cells
5. Researchers discover way to make cells in the eye sensitive to light
6. Priming embryonic stem cells to fulfill their promise
7. Lack of enzyme turns fat cells into fat burners
8. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
9. Elusive HIV shape change revealed; Key clue to how virus infects cells
10. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
11. Enzyme allows B cells to resist death, leading to leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sperm stem cells closer being like embryonic stem cells

(Date:8/27/2014)... effective doses of the HIV drug maraviroc, a new ... completed before the drug was licensed in 2007, included ... key to removing maraviroc from the body. The current ... protein including nearly half of African-Americans end ... those who lack the protein even when given the ...
(Date:8/27/2014)... neural circuits in the brain of mice, scientists ... The research, led by Howard Hughes Medical Institute ... Technology (MIT), reveals that the connections between the ... about an experience and the part of the ... experience are malleable. , Altering those connections ...
(Date:8/27/2014)... to listen carefully to someone, the first thing we ... is stop moving altogether. This strategy helps us hear ... movements. , This interplay between movement and hearing also ... evidence has long suggested that the brain,s motor cortex, ... gives rise to our conscious perception of sound. , ...
Breaking Biology News(10 mins):Dosage of HIV drug may be ineffective for half of African-Americans 2Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4Stop and listen: Study shows how movement affects hearing 2Stop and listen: Study shows how movement affects hearing 3
... ORLANDO, Fla. Soy food consumption did not ... survivors of breast cancer, according to the results of ... 2011, held April 2-6. Researchers investigated the association ... survivors, using data from a multi-institution collaborative study, the ...
... America (ESA) has selected 37 insect-science symposia for its ... http://entsoc.org/entomology2011 ). The symposia will address important ... Disorder, insect control, invasive species, medical and veterinary entomology, ... BEES AND COLONY COLLAPSE DISORDER Bee ...
... premature aging of immune cells, which may make people more ... new UCSF-led study. The findings indicate that accelerated ... is dependent upon how long someone is depressed, particularly if ... March 2011 by the journal PLoS One and ...
Cached Biology News:Soy isoflavones not a risk for breast cancer survivors 2Entomology 2011 symposia selected 2Entomology 2011 symposia selected 3Study finds link between chronic depression and accelerated immune cell aging 2Study finds link between chronic depression and accelerated immune cell aging 3
(Date:8/27/2014)... BOSTON , Aug. 27, 2014 Rhythm, ... diseases and genetic deficiencies that result in metabolic disorders, ... on Form S-1 with the U.S. Securities and Exchange ... of shares of its common stock. The number of ... the offering have not yet been determined. ...
(Date:8/27/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Global Biodegradable Packaging ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About Biodegradable Packaging ... readily decomposed by the action of microorganisms. ... in terms of raw materials, production technology, ...
(Date:8/27/2014)... of nature,s mysteries is how plants survive impact ... the sun,s rays, while using this energy for ... in the plant,s blades quickly dissipate the energy ... quakes. Researchers at DTU Physics have now managed ... algae and bacteria contain light-absorbing proteins which play ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... available in its catalogue: Global Chelating ... About Chelating Agent A chelating ... covalent bonds with metal ions, thereby forming a ... some metal-ions have on chemical processes, formulations, and ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7DTU researchers film protein quake for the first time 2Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4
... Alfalight , a firm that makes high-power ... has established ties with Chinese distributor Sanetronic Company ... Hong Kong. The company was founded in 1987 as ... has eight offices in China, including Beijing, Shanghai, Shenzhen, ...
... research, nanotechnology, farm waste management and produce storage have emerged ... Transfer Award. , ,Judges for the contest have winnowed the ... The $5,000 grand prize will be presented to the winner ... in Milwaukee. , ,The finalists are: , , GHD ...
... The Joint Finance Committee rejected Governor Jim Doyle's proposal for ... The proposal, a plan to charge consumers for their music, ... several proposals turned down by the budget review panel. , ... on electronic entertainment called by some detractors the "iPod ...
Cached Biology Technology:Five remaining firms vie for Tech Transfer award 2Five remaining firms vie for Tech Transfer award 3Finance Committee rejects extra tax on Internet buys 2Finance Committee rejects extra tax on Internet buys 3
... This CLS number is a new product ... number. If showing no availability yet, please ... or contact customer service for assistance. ... Comp Dim: surface area 500 cm 2 ...
... Ideal for cell culture scale-up, these ... 10 7 - 10 9 range ... bottles or spinner flasks. • High mechanical ... leak tested prior to shipping • Certified ...
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
Mouse monoclonal [7B9] to beta II Tubulin ( Abpromise for all tested applications). Antigen: Synthetic peptide, CEEEEGEDEA found at the c-terminus of beta II tubulin. Entrez GeneID: 10383 ...
Biology Products: