Navigation Links
Sperm created in the laboratory from embryonic stem cells produce viable progeny

Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for infertility.

Previous studies have shown that ES cells grown in the laboratory can differentiate into primordial germ cells that then give rise to cells resembling mature egg and sperm cells, known as gametes. However, the functionality of the gametes has not been thoroughly tested and many questions about the viability of these cells remain unanswered. Dr. Karim Nayernia and Dr. Wolfgang Engel from the Institute of Human Genetics at the University of Goettingen in Goettingen, Germany and colleagues developed a new strategy for generating mature sperm cells in the laboratory using ES cells from mice and went on to test the functionality of the ES-derived sperm.

ES cells were treated with specific factors know to direct sperm production and screened for characteristics associated with primordial and spermatagonial stem cells. The researchers demonstrated that these cells could be further differentiated into mature sperm in the laboratory or could be transplanted into the testes of mice where they retained the capacity develop into sperm. Intra-cytoplasmic injection of the ES-derived sperm into mouse eggs resulted in successful fertilization and the resulting early stage embryos were successfully transplanted into mice. Six of the seven mice born developed into adult mice.

The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro model s ystem for studies of mammalian gametogenesis, as well as for developing new strategies for generation of transgenic mice and may one day facilitate nuclear transfer technology and infertility treatment," offers Dr. Nayernia.


'"/>

Source:Cell Press


Related biology news :

1. Sperm trading can resolve hermaphrodite mating conflicts
2. Sperm stem cells closer to being like embryonic stem cells
3. Molecular research suggest shift needed in how some drugs are created
4. All placebos not created alike
5. Pinball protons created by ultraviolet rays and other causes can lead to DNA damage
6. Polynesia explorers created worldwide web of scientific knowledge
7. Cloned mice created from fully differentiated cells, a milestone in cloning research
8. Researcher examines polymers created with poultry feathers
9. Early-stage sperm cells created from human bone marrow
10. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
11. Melanoma vaccine strategy shows promise in laboratory experiments
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:9/18/2017)... ... September 18, 2017 , ... ... optimization firm for the life sciences and healthcare industries, announces Bryan Coddington ... , What: Digital Transformation in Medical Device – The Journey to FDA Compliant ...
(Date:9/15/2017)... ... 15, 2017 , ... San Diego based graphene materials and ... round of financing, totaling $600,000. The round was entirely filled by existing ... at a company valuation of $10M. , Grolltex, short for ‘graphene-rolling-technologies’, ...
(Date:9/14/2017)... ... September 14, 2017 , ... DrugDev , ... at the third annual DrugDev Summit, November 7-8, 2017 in Philadelphia, PA. The ... progressive clinical research leaders for best practice case studies, keynote presentations, lively breakout ...
(Date:9/14/2017)... ... September 14, 2017 , ... ... utilizing its extensive experience with Health Economics and Outcomes Research (HEOR) and ‘big ... laboratory testing. In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 ...
Breaking Biology Technology: