Navigation Links
Sperm created in the laboratory from embryonic stem cells produce viable progeny

Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for infertility.

Previous studies have shown that ES cells grown in the laboratory can differentiate into primordial germ cells that then give rise to cells resembling mature egg and sperm cells, known as gametes. However, the functionality of the gametes has not been thoroughly tested and many questions about the viability of these cells remain unanswered. Dr. Karim Nayernia and Dr. Wolfgang Engel from the Institute of Human Genetics at the University of Goettingen in Goettingen, Germany and colleagues developed a new strategy for generating mature sperm cells in the laboratory using ES cells from mice and went on to test the functionality of the ES-derived sperm.

ES cells were treated with specific factors know to direct sperm production and screened for characteristics associated with primordial and spermatagonial stem cells. The researchers demonstrated that these cells could be further differentiated into mature sperm in the laboratory or could be transplanted into the testes of mice where they retained the capacity develop into sperm. Intra-cytoplasmic injection of the ES-derived sperm into mouse eggs resulted in successful fertilization and the resulting early stage embryos were successfully transplanted into mice. Six of the seven mice born developed into adult mice.

The results of this study establish that the ES cell derived cell lines can produce functional sperm in the laboratory which can be used to successfully fertilize eggs and support full-term development into embryos and adult mice. "Our approach provides an accessible in vitro model s
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Sperm trading can resolve hermaphrodite mating conflicts
2. Sperm stem cells closer to being like embryonic stem cells
3. Molecular research suggest shift needed in how some drugs are created
4. All placebos not created alike
5. Pinball protons created by ultraviolet rays and other causes can lead to DNA damage
6. Polynesia explorers created worldwide web of scientific knowledge
7. Cloned mice created from fully differentiated cells, a milestone in cloning research
8. Researcher examines polymers created with poultry feathers
9. Early-stage sperm cells created from human bone marrow
10. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
11. Melanoma vaccine strategy shows promise in laboratory experiments
Post Your Comments:
(Date:9/19/2014)... of Oklahoma biology professor will study multifunctional and ... movements with a National Science Foundation grant in ... , Ari Berkowitz, professor in the Department of ... focus on the differences between the multifunctional and ... neurotransmitters they use and what connections they make. ...
(Date:9/19/2014)... are a species which over thousands of years has adapted ... a substance that makes the cold dangerous for you. , ... albidus , and the cold provoking substance, called nonylphenol, comes ... Nonylphenol is suspected of being a endocrine disruptor, but when ... the worm,s ability to protect the cells in its body ...
(Date:9/19/2014)... legume plants regulate their symbiotic relationship with soil ... through the plant structure from leaves into the ... in the roots. This collaborative study was conducted ... Biology, the Graduate University for Advanced Studies (SOKENDAI), ... in Japan. , Legumes, an important plant ...
Breaking Biology News(10 mins):Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3For legume plants, a new route from shoot to root 2
... will launch a new international journal called Cellular ... Springer is already the publisher of the BMES ... and Molecular Bioengineering will publish first-rate articles in ... thus advancing this rapidly evolving new field that ...
... A consortium of researchers led by the Genome Sequencing Center ... the completion of a draft sequence of the corn genome. ... partnership with the U.S. Department of Agriculture (USDA) and the ... to sequence the corn genome. The goal of the project ...
... KEY, FLA. Dr. Peter Glynn, a professor ... and Atmospheric Science has been selected to receive the ... extraordinary research and scholarly pursuits, and provides the recipient ... This marks the second time Glynn, who received the ...
Cached Biology News:Springer expands publishing partnership with the Biomedical Engineering Society 2All eyes and ears on the corn genome 2All eyes and ears on the corn genome 3UM coral scientist Peter Glynn wins award for scholarly activity 2
(Date:9/18/2014)... 18, 2014  Health Enhancement Products, Inc. (OTCQB: HEPI), a ... bioactive compounds and metabolic processes, is pleased to announce the ... directors. Ms. Nola E. Masterson , a ... board effective September 17, 2014. "We,re very ... our board," states Andrew Dahl , President and CEO. ...
(Date:9/18/2014)... Bryan-College Station, Texas (PRWEB) September 18, 2014 ... University System Chancellor John Sharp, Texas A&M Health ... from the U.S. Department of Health and Human ... GSK today dedicated a national pandemic influenza vaccine ... will serve as an anchor for the Texas ...
(Date:9/18/2014)... Research and Markets has announced the addition ... Report, 2014-2017" report to their offering. ... differentiate into specialized cells and can divide (through mitosis) ... be applied to treatment of cardiovascular diseases, leukemia (a ... or lesion of liver, kidney and other parenchymal organs, ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "Global Human Albumin Industry Report 2014" ... Human Albumin Industry Report 2014 is a professional and ... human albumin industry. The report provides a ... and industry chain structure. The human albumin market analysis ...
Breaking Biology Technology:Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3
... 100% organic toxic mold remedy for mold remediation professionals and homeowners. ... used effectively in the aftermath of the flooding in Katrina. ... ... -- Organic Environmental Technology ( http://www.organicet.com ) announced today the availability ...
... Penn State will receive $5 million over four ... a National Center for Nanotechnology Applications and Career ... national leader in nanotechnology education and workforce development ... was home to the NSF Regional Center for ...
... Sciences,Holdings, Inc. (Nasdaq: ADLS ) a biopharmaceutical company ... in the,therapeutic areas of infection, cancer and respiratory diseases, ... Bank to increase,its line of credit from $4 million ... by 12 months to January 1, 2011. The closing ...
Cached Biology Technology:Katrina Proven Certified Organic Toxic Mold Remedy Now Available for Mold Remediation Professionals and Homeowners 2Katrina Proven Certified Organic Toxic Mold Remedy Now Available for Mold Remediation Professionals and Homeowners 3Katrina Proven Certified Organic Toxic Mold Remedy Now Available for Mold Remediation Professionals and Homeowners 4Penn State gets $5M NSF grant for Nanotech Applications and Career Knowledge 2Advanced Life Sciences Completes Debt Transaction 2
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: