Navigation Links
Speeding the search for elusive chromosomal errors

oarray by using it to test samples from two patients with known chromosomal rearrangements and well-characterized genetic diseases. In a blinded analysis, the experiment found the correct location of the abnormal regions.

In the second part of the study, the researchers studied samples from 10 patients with multiple congenital anomalies, all of whom had previously normal results from karyotype and subtelomeric testing. The team identified novel submicroscopic deletions in two patients. These deletions, one on chromosome 1 and the other on chromosome 3, were not detected in the patients' parents, providing strong evidence that the deletions were the underlying cause of the multiple defects seen in the children.

Dr. Shaikh's laboratory has subsequently used the microarray to analyze DNA samples from more than 60 patients, and have detected novel microdeletions and microduplications in 25 percent of the cases. He also has received a grant to investigate chromosomal rearrangements in bipolar disease, a complex disorder thought to involve interactions among multiple genes.

Dr. Shaikh is currently collaborating with other researchers at Children's Hospital to evaluate other, higher-density gene chips (holding more than 500,000 oligonucleotides), which provide greater resolution. His team is also developing better computational tools to evaluate data from these chips. "Our ability to detect even smaller rearrangements will only get better as there are improvements in the resolution of the microarrays and the computational tools required to analyze and mine the data generated," said Dr. Shaikh.

As he pursues ongoing studies to enroll and study more patients with congenital defects, Dr. Shaikh collaborates with Elaine H. Zackai, M.D., director of Clinical Genetics at Children's Hospital. "It is extremely rewarding to finally have tools to identify heretofore undetectable, cryptic rearrangements and to be able to provide a diagnosis for the pa
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2 3 4

Related biology news :

1. Speeding discovery of the human cancer genome
2. Speeding fingertip discovery -- 20 years of protein info in 1 place
3. Researchers discover way to make cells in the eye sensitive to light
4. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
5. Columbia research lifts major hurdle to gene therapy for cancer
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Researchers Uncover Key Step In Manufacture of Memory Protein
8. Research advances quest for HIV-1 vaccine
9. Research on Worms Yields Clues on Aging
10. U of M researcher examines newly emerging deadly disease
11. NYU researchers simulate molecular biological clock
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Speeding the search for elusive chromosomal errors

(Date:12/17/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ) ... Chemical Sensor Market 2015-2019" report to their ... One major trend upcoming in this ... in biomedical applications. Chemical sensors help in recording ... during surgical procedures. The Global Chemical Sensor market ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition ... individuals. Facial recognition system measures the overall facial ... edges, mouth, and the distance between eyes. Facial ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... of Pharmaceutical Scientists (AAPS) is a professional, scientific ... academia, government and other research institutes worldwide. Founded ... for the exchange of knowledge among scientists to ... timely scientific programs, on-going education, information resources, and ...
... / b3c newswire / - NiKem Research is ... Ministry of Health, GLP certification of its bioanalysis facilities to ... has provided for many years high quality cost-effective bioanalytical support ... in vivo PK services associated to various drug ...
... September 14, 2009 / b3c newswire / - ... events for the healthcare, education and energy markets, and ... to the scientific community, today announced the initial slate ... BioConference Live is the first of its kind online-only ...
Cached Biology News:AAPS and PhRMA co-sponsor stability workshop 2NiKem Research receives certification for GLP Bioanalysis 2BioConference Live Attracts Major Life Science Sponsors 2BioConference Live Attracts Major Life Science Sponsors 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... Further Development Of AeroLEF As President Of ... ... BioSciences Inc.,(AMEX: YMI , TSX: YM, AIM: YMBA), an oncology ... that the Clinical Hold imposed by the US Food and Drug,Administration ...
... Antibody Targets in the Areas of Cancer, Stem Cell and ... ... 19 Sigma-Aldrich (Nasdaq:,SIAL) today announced it has entered into ... of monoclonal antibodies.,Scientists at the University of California, San Francisco ...
... on Friday, June 20, 2008, NEW YORK, June ... plaintiffs, litigation law firms in America, filed a lawsuit ... York City Fire,Department Emergency Medical Technician whose diabetes was ... Armstead, was one,of the many brave responders on the ...
Cached Biology Technology:YM BIOSCIENCES ANNOUNCES FDA LIFTS CLINICAL HOLD ON AEROLEF(R) AND CLEARANCE OF A PHASE II CLINICAL TRIAL 2YM BIOSCIENCES ANNOUNCES FDA LIFTS CLINICAL HOLD ON AEROLEF(R) AND CLEARANCE OF A PHASE II CLINICAL TRIAL 3Sigma-Aldrich Announces Collaboration to Develop Monoclonal Antibodies 2Sigma-Aldrich Announces Collaboration to Develop Monoclonal Antibodies 3Weitz & Luxenberg Files Seroquel Diabetes Lawsuit Against AstraZeneca 2
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
...
Biology Products: