Navigation Links
Speeding discovery of the 'human cancer genome'

Two gene discoveries announced in separate reports in the June 30, 2006 issue of Cell highlight one way to speed through the human genome in search of those genes most important for spawning cancer. Both groups say that a critical element in the enterprise to efficiently characterize the "human cancer genome" --a comprehensive collection of the genetic alterations responsible for major cancers--is the strategic comparison of human tumors with those of mice.

As a demonstration of the value of such strategic comparisons between species, the researchers report promising finds: one of the research teams identified two genes that can--in some circumstances--conspire to produce liver cancer, while the second uncovered a gene important to the spread of melanoma, the most serious form of skin cancer. Such functionally important genes, and the larger genetic pathways of which they are a part, are also those with the most promise as potential targets for cancer drugs, according to the researchers.

"With improvements in genome technology, we've found that human cancer is noisy," said Howard Hughes Medical Institute investigator Scott Lowe of Cold Spring Harbor Laboratory. "There are lots of alterations, only some of which causally contribute to the disease."

"Genetically engineered mice, by definition, develop more defined cancers than humans," he said. "Mice can therefore be used as a filter to help reduce that noise, and as a tool to determine, in areas of chromosomal alteration, what changes are functionally relevant."

The difficulty stems from the fact that studies that scan the genomes of human tumors for differences typically find hundreds to thousands of genes that distinguish cancer and noncancer.

Some of those differences are at the root of the cancer, while others are what Lowe refers to as "evolutionary byproducts." In other words, they are genes that simply came along for the ride with those that actual
'"/>

Source:Cell Press


Page: 1 2 3 4

Related biology news :

1. Speeding the search for elusive chromosomal errors
2. Speeding fingertip discovery -- 20 years of protein info in 1 place
3. Protein discovery could unlock the secret to better TB treatment
4. Purdue proves concept of using nano-materials for drug discovery
5. UCSD discovery may help extend life of natural pesticide
6. Leprosy microbes lead scientists to immune discovery
7. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
8. Researchers make surprise discovery that some neurons can transmit three signals at once
9. Important discovery about second most fatal cancer
10. Harmless virus may hold key to more effective HIV drug discovery
11. Fundamental discovery -- Bone fracture
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Speeding discovery the human cancer genome

(Date:8/21/2014)... 18-22, 2014 , WHERE: , San Diego ... CA 92101 , WHAT: , Invited and ... latest research in human genetics. Examples of sessions ... on rare genetic variants in health and disease, ... sun sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) , ...
(Date:8/21/2014)... tube connectors, designed by an international standards process, will ... According to an invited review published in the OnlineFirst ... NCP ), the official journal of the American Society ... will greatly reduce the occurrence of misconnection that can ... connectors, which are used to join medical devices, components, ...
(Date:8/21/2014)... has successfully replicated one of the crucial steps in ... sunlight which could manufacture hydrogen as a fuel. , ... an exciting prospect to use them to create hydrogen, ... Hingorani, from the ARC Centre of Excellence for Translational ... Hydrogen offers potential as a zero-carbon replacement for petroleum ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2New feeding tube connectors will improve patient safety 2Water and sunlight the formula for sustainable fuel 2
... marker for Alzheimer,s disease rises and falls in the spinal ... researchers at Washington University School of Medicine in St. Louis ... young people and reinforces a link between increased Alzheimer,s risk ... The brain,s relative inactivity during sleep may provide an ...
... NEW YORK (Sept. 26, 2011) -- The National Institutes ... Research Project (T-R01) Award to fund research into risk factors ... area of the affected baby,s spine or brain is not ... Margaret Elizabeth Ross and Dr. Christopher E. Mason at Weill ...
... Rochelle, NY, September 26, 2011Magnetic resonance tractography (MRT) ... human brain anatomy and, as MRT methods and ... and illuminating information on brain activity and connectivity. ... this technology is explored in a forward-looking review ...
Cached Biology News:Marker for Alzheimer's disease rises during day and falls with sleep 2Marker for Alzheimer's disease rises during day and falls with sleep 3NIH awards $5.5 million grant to Weill Cornell for research into preventing spina bifida 2NIH awards $5.5 million grant to Weill Cornell for research into preventing spina bifida 3
(Date:8/22/2014)... The identification of protein-coding variants underlying ... by exome sequencing. Built on Roche NimbleGen’s proprietary ... EZ Developer system has been a proven tool ... present how he achieved coverage statistics similar to ... exome kits. With over 236,000 SNPs and over ...
(Date:8/21/2014)... 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products marketed as XIAFLEX ® ... U.S. and XIAPEX ® in the EU, ... randomized, double-blind Phase 2a study of CCH for ... panniculopathy. The results showed that all three doses ...
(Date:8/21/2014)... at the Institute for Molecular Medicine Finland (FIMM), ... developed a novel "man and machine" decision support ... aid was described in PLOS One ... based on computer vision algorithms similar to those ... of only the diagnostically most relevant areas. Tablet ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... Fertilizer Industry” is a professional and in-depth ... The report provides basic Seaweed Fertilizer information, ... industry chain structure as well as industry ... analysis, including domestic market as well as ...
Breaking Biology Technology:Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5A novel 'man and machine' decision support system makes malaria diagnostics more effective 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... Elizabeth P. Roquemore, Sam Murphy, *Stephen ... Swinburne , , ... 9NA England, , ... throughput imaging systems, analysis algorithms and associated,cellular assays have begun to be used ...
... , Key words: ... LC-MS/MS • DeCyder MS • differential analysis, ... was used in conjunction with tandem mass spectrometry (MS/MS) to separate ... tree, Olea europaea . DeCyder™ MS Differential Analysis Software (DeCyder ...
... Karlsson, and H. Lindgren , ... Sweden , , ... columns prepacked with Ni Sepharose 6 Fast Flow without the need for a ... the highest available on the market, and separations can be completed in as ...
Cached Biology Technology:Is Z' factor the best assessment for the quality of cellular assays delivering higher content? 2Is Z' factor the best assessment for the quality of cellular assays delivering higher content? 3Is Z' factor the best assessment for the quality of cellular assays delivering higher content? 4Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 2Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 3Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 4Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 5Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 6Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 7Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 8Detection, identification, and quantitation of an olive allergen using Ettan MDLC, MS/MS, and DeCyder MS 9New gravity-flow column gives faster and simpler purification of histidine-tagged proteins 2New gravity-flow column gives faster and simpler purification of histidine-tagged proteins 3New gravity-flow column gives faster and simpler purification of histidine-tagged proteins 4
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
Cell Culture Flask, 75 cm, treated polystyrene...
Cell Culture Flask, 75 cm, nontreated polystyrene...
... research laboratory, the revolutionary Luminex 100 System ... and in real time enhancing your operational ... includes the Luminex 100, the XY Platform, ... which enables you to simultaneously assay up ...
Biology Products: