Navigation Links
Speak up: Louder neurons form more connections

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to explain how early experiences guide brain development.

The work, published in the April 21 issue of Nature, takes advantage of tiny, see-through zebrafish. Stephen Smith, PhD, professor of molecular and cellular physiology at the Stanford University School of Medicine, and his graduate student Jackie Hua immersed 3-day-old fish in a breathable, Jell-O-like substance that kept the fish alive but immobile. The researchers could then focus video cameras on the fish’s developing brain to watch how the branches of individual neurons grew and shrank over time.

It turns out that determining which of the branches will grow follows an age-old axiom: The squeaky neuron gets the grease. “Louder neurons drown out their quieter neighbors,?Smith said.

Working out this seemingly simple rule took some technical finesse. Hua created zebrafish with a few brain cells that made a protein that prevented them from firing their normal electrical signals. These cells were also engineered to produce a protein that glowed green under the appropriate light.

Hua looked for green neurons in her immobilized fish to see how their branches fared compared with neighboring neurons that fired normally. The green neurons didn’t compete well.

Although the poorly-firing green neurons still formed extensive branching structures, which the researchers call the neuron’s arbor, most of those branches eventually receded while neighboring neurons formed a large number of stable connections. When the fish were five days old, the green neurons had a smaller, less complex arbor than those of neighboring neurons.

“We know that the arbor should occupy a certain amount of space
'"/>

Source:Stanford University


Page: 1 2

Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Eating, body weight regulated by specific neurons
5. New neurons take baby steps in the adult brain
6. Algal protein in worm neurons allows remote control of behavior by light
7. Picking apart how neurons learn
8. Researchers get neurons and silicon talking
9. Mechanism for memory revealed in neurons of electric fish
10. Attention shoppers: Researchers find neurons that encode the value of different goods
11. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Speak Louder neurons form more connections

(Date:9/29/2014)... "human activities in this area of the world have contributed ... grown for use as a cooking oil and biofuel, while ... the most widely produced edible oil in the world, and ... soybean oil. , The environmental effects of such growth have ... crop, and the preferred method is fire. The clearing often ...
(Date:9/29/2014)... MADISON, Wis. Mountain pine beetles get a bad ... for killing pine trees over tens of millions of ... last decade. , But contrary to popular belief, ... severe wildfires like those that have recently swept through ... role in the ecological severity of fires than these ...
(Date:9/29/2014)... (Boston) A review article published online in ... that happen in the brain as a result of ... the sleep cycle. , Clinical assessments and research ... from severely disrupted sleep. This can occur when people ... or when they are abstaining. , "Sleep-wake disturbances ...
Breaking Biology News(10 mins):Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... about the quality of ingested food. It comprises five ... stimuli. The possibility for an additional taste modality ... animals exhibit a spontaneous attraction for fats, but the ... debate. , In a paper appearing in the ...
... from researchers at Harvard Medical School and Massachusetts Institute ... Cancer Conference (ECCO) have shown for the first time ... , Nucleic acid ligands (referred to as aptamers) ... to target antigens with high specificity and affinity; analogous ...
... may owe its existence to tiny microorganisms living in ... the vital services these microbes perform for the planet ... the American Academy of Microbiology, entitled Marine Microbial Diversity: ... likely began in the oceans, marine microorganisms are the ...
Cached Biology News:Researchers use 'trickery' to create immune response against melanoma 2Researchers use 'trickery' to create immune response against melanoma 3Researchers use 'trickery' to create immune response against melanoma 4Understanding the oceans microbes is key to the Earth's future 2
(Date:9/30/2014)... The overall research objective was to ... and use. Most researchers outsource NGS technologies; however, ... within the next 12 months. Data accuracy and ... sequencing instruments. Disease-related research is the dominant use ... to surge, with half of the respondents planning ...
(Date:9/30/2014)... 2014 Rainbow Scientific, Inc. (RSI), ... recently opened an online store to add customer ... lines developed and manufactured by Biological Industries, Inc. ... Biological Industries’ Nutristem® serum-free, xeno-free reagents for human ... cell (hESC) culture. , The online store ...
(Date:9/30/2014)... 30, 2014 Back in the 1970’s, many ... feet. per employee, which included space for circulation and file ... Jeff Howell, partner at Nidea Corporate Real Estate / ... “By the year 2000, however, 250 square feet per ... number come down to 175 to 225 square feet, and ...
(Date:9/29/2014)... the start of the military conflicts in Iraq and ... United States with traumatic brain injury caused by exposure ... improvised explosive devices, or IEDs. Symptoms of traumatic brain ... headaches and nausea, to more severe impairments in memory ... of Defense has recognized the critical importance and complexity ...
Breaking Biology Technology:Global Next-generation Sequencing Trends 2Rainbow Scientific, Inc. opens online store for state-of-the-art stem cell culture and cytogenetic reagents 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... race the fastest cars they can build and win the ... and technicians from Ohio State University (OSU) and Wisconsin-based ... million dollar grand prize awarded to the winner of the ... Research Projects Agency (DARPA) has a Congressional mandate to reward ...
... announced today the hiring and appointment of Tom Schwei ... bioinformatics company. Schwei has 25 years of local business ... PanVera Corporation and Invitrogen Corporation. , ,Tom brings ... said Fred Blattner, DNASTARs chief of operations and president. ...
... kettle of molten steel as the representative symbol of ... to the cubicle farm. Instead of coke and iron ... transform data and information into knowledge and ideas: An ... its output is knowledge. Every physical product has a ...
Cached Biology Technology:Oshkosh Truck Teams with OSU to Compete in DARPA Million Dollar Tech Derby 2Oshkosh Truck Teams with OSU to Compete in DARPA Million Dollar Tech Derby 3Transforming Information to Knowledge 2
... The biolistic PDS-1000 He system ... gas to accelerate micron-size nucleic acid-coated ... necessary to transfect cells, tissues, or ... the cell surface. The system includes ...
Sf21 Insect Cells (Frozen) in Max-XP Medium...
... is used for conventional PCR and thermal ... personal thermal cycler, which features a 96-well ... tubes or plates, programmable time, temperature, and ... modes of temperature control. The system also ...
... with colony-picking capabilities, 110-120 V, uses floating ... oligonucleotides, carbohydrates, lipids, and other biomolecules onto ... This system can also be used for ... in diameter and for inoculating 96- or ...
Biology Products: