Navigation Links
Some Brain Cells 'Change Channels' To Fine-tune The Message

ls that connect to it. Although they don't physically touch, the cell and its neighbor are so close to one another at these connection points, called synapses, that molecules released from one cell travel immediately to the next.

These molecules dock at specific places, or receptors, on the cell and trigger "channels" in the cell's membrane to open. Depending on the receptor and the channel, in will flow sodium, calcium, chloride or other charged atoms that then keep the communication process going.

In the cells in the cerebellum, a channel made of proteins called AMPA receptors, built from subunits called GluR3 and GluR4, is usually found at the synapse. If the cells are shocked with an electric current, within minutes the channels are replaced by ones made of GluR2 and GluR3. After the swap, sodium can still get in, but calcium is kept out.

To learn more about how this takes place, the Hopkins researchers studied brain cells from genetically engineered mice. Through their experiments, the researchers determined that the PICK1 and NSF proteins are both required for the calcium-forbidding channel to move into place at the synapse. Exactly how they help the channels move is still unknown, as is why the cells change their channels.

Part of the answer is likely to be self-preservation: Too much calcium inside nerve cells can kill them. But Huganir points out that calcium does a lot of things inside cells, suggesting that the channel swap might be accomplishing more than just keeping the cell alive. "Calcium turns some processes on, and it turns others off," he says. "My personal belief is that the cells might be doing more than just protecting themselves by keeping calcium out."

In some cases, protection might be enough of a goal. In people with Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), some muscle-controlling nerve cells die because too much of the brain chemical glutamate binds to the cells' AMPA receptors,
'"/>

Source:Hopkins Medecine


Page: 1 2 3

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
10. Brain-injury rehabilitation depends on acetylcholine circuitry
11. Brain May Be Less Plastic Than Hoped
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Some Brain Cells Change Channels Fine tune The Message

(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... --Research and Markets , ... ) has announced the addition of the ... to their offering. One major ... technology. With continuous advances in technology, it is ... standard that meets the needs and expectations of ...
(Date:12/11/2014)... , Dec. 10, 2014  Data Sciences ... monitoring, has released a new series of digital ... preclinical toxicology researchers. M series, part of the ... collect the best possible physiologic data when incorporating ... Adding functional endpoints to toxicology studies has evolved ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... A gene signature, first identified in mouse colon cancer ... cancer recurrence, according to a recent study by Vanderbilt-Ingram ... March issue of Gastroenterology , could help personalize ... of cancer-related deaths in the United States by ...
... by Monash University scientists could see humble cotton thread ... capable of detecting diseases such as kidney failure and ... used ordinary cotton thread and sewing needles to literally ... the size of a postage stamp. Microfluidic analytical ...
... CHICAGO --- Two to three times more pregnant women ... based on new measurements for determining risky blood sugar ... to a study that was coordinated by investigators at ... of this study, more than 16 percent of the ...
Cached Biology News:Gene signature may improve colon cancer treatment 2Gene signature may improve colon cancer treatment 3How long is a piece of thread? Long enough to save a life 2Twice as many women to be diagnosed with gestational diabetes 2Twice as many women to be diagnosed with gestational diabetes 3
(Date:12/24/2014)... According to Ross Selinger, President of Selinger ... the national office market continues to be strong, driven by ... by the third quarter’s surprising 3.9% GDP, unemployment decreasing to ... have held inflation down and the Fed is keeping interest ... remaining soft. , This solid economic news is having a ...
(Date:12/24/2014)... China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... Shandong Taibang Biological Products Co. Ltd., has received ... Food and Drug Administration (the "CFDA") for its ... in the Company,s public filings, the CFDA inspected ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 /PRNewswire/ ... study of mazindol in children with attention deficit/hyperactivity disorder ... December 2014 . The paper, titled ... attention deficit/hyperactivity disorder" ( Konofal et al, ... eCollection 2014 ) shows that mazindol might be ...
(Date:12/22/2014)... 22, 2014 GenomeDx Biosciences today announced that ... Classifier, a genomic test for prostate cancer, was able ... managed by radical prostatectomy without adjuvant therapy. Although rapid ... uncommon, using tumor genomics to identify these men who ... an important advance. The study has been published ...
Breaking Biology Technology:ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3
... life is founded on the interactions of millions of proteins. ... molecular mechanisms of life. The problem is that proteins are ... of them and they appear in all sizes and weights. ... universities of Freiburg and Bochum have achieved a breakthrough in ...
... smaller, faster computer chips, researchers are increasingly turning to ... The problem: the manufacturing techniques required to make ... until now. Researchers at Ohio State University have ... common to the chip-making industry today. This work ...
... The Pittsburgh Life Sciences Greenhouse (PLSG), the ... and business growth programs to the region,s life ... closed $725,000 in direct company investments. , ... support prototyping a family of patent-pending catheters for ...
Cached Biology Technology:Powerhouses in the cell dismantled 2Quantum computer chips now 1 step closer to reality 2Quantum computer chips now 1 step closer to reality 3The Pittsburgh Life Sciences Greenhouse Invests $725K in Portfolio Companies 2
... internal standard for the quantification of 5-OxoETE ... is a polyunsaturated keto acid formed by ... It stimulates cytosolic calcium levels in neutrophils ... selectively stimulates the migration and degranulation of ...
... 4,600 to Over 3 Million Genotypes Per ... capable of performing 4,600 to over 3 ... GenomeLab family of products*, this automated, scalable, ... SNPs in each well of an arrayed ...
... These protein size markers are a mixture ... 16 to 100 kDa. The markers provide ... gels after staining with Coomassie blue. Because ... II sequence, the markers can also be ...
... solid. A nucleoside antibiotic that inhibits ... of N-glycosidic protein-carbohydrate linkages. Active ... yeasts, fungi, and viruses. Inhibits the ... human T-lymphoblastoid cells. Also inhibits thrombin-induced ...
Biology Products: