Navigation Links
Some Brain Cells Change Channels

ells that connect to it. Although they don't physically touch, the cell and its neighbor are so close to one another at these connection points, called synapses, that molecules released from one cell travel immediately to the next.

These molecules dock at specific places, or receptors, on the cell and trigger "channels" in the cell's membrane to open. Depending on the receptor and the channel, in will flow sodium, calcium, chloride or other charged atoms that then keep the communication process going.

In the cells in the cerebellum, a channel made of proteins called AMPA receptors, built from subunits called GluR3 and GluR4, is usually found at the synapse. If the cells are shocked with an electric current, within minutes the channels are replaced by ones made of GluR2 and GluR3. After the swap, sodium can still get in, but calcium is kept out.

To learn more about how this takes place, the Hopkins researchers studied brain cells from genetically engineered mice. Through their experiments, the researchers determined that the PICK1 and NSF proteins are both required for the calcium-forbidding channel to move into place at the synapse. Exactly how they help the channels move is still unknown, as is why the cells change their channels.

Part of the answer is likely to be self-preservation: Too much calcium inside nerve cells can kill them. But Huganir points out that calcium does a lot of things inside cells, suggesting that the channel swap might be accomplishing more than just keeping the cell alive.

"Calcium turns some processes on, and it turns others off," he says. "My personal belief is that the cells might be doing more than just protecting themselves by keeping calcium out."

In some cases, protection might be enough of a goal. In people with Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), some muscle-controlling nerve cells die because too much of the brain chemical glutamate binds to the cells' AMPA r
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Drug That Tags Decision-making Areas Of The Brain May Aid
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Some Brain Cells Change Channels

(Date:8/6/2015)... , Aug. 6, 2015  Today, U.S. ... visit Crossmatch ™ to learn firsthand how ... protect data. Crossmatch is a world leader in ... and expertise are helping federal agencies and commercial ... security.   "The vast majority of ...
(Date:8/6/2015)... , Aug. 6, 2015 Synaptics Inc. ... human interface solutions, today announced collaboration with Microsoft ... Windows 10. Microsoft leveraged Synaptics, deep expertise in ... system. Through stringent testing, Synaptics, ... certified with Microsoft,s Precision TouchPad (PTP) specification empowering ...
(Date:8/5/2015)... August 5, 2015 Transparency Market ... Recognition Market - Global Industry Analysis, Size, Share, Growth, ... for facial recognition is forecast to reach US$ 2,671.8 ... demand for surveillance systems by civil and government agencies. ... crimes and terrorist activities across the globe that would ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
... women may worry about the effects of air pollution on ... carbon monoxide and fine particles in the air during pregnancy ... or preeclampsia -- a serious condition that arises only during ... a University at Buffalo epidemiologist. , The research was ...
... Safran, a professor at the Weizmann Institute in Israel, has ... Pierre-Gilles De Gennes Lecture Prize. The prize, accompanied by 1,000, ... (EPJE). Safran is the author of numerous articles in ... Prize, which was named after the Nobel laureate who founded ...
... cessation therapy is quickly taking shape. New evidence ... on Drug Abuse (NIDA) suggests that combining information about ... habits can accurately predict which nicotine replacement therapy will ... conceivable we,ll have a practical test that could take ...
Cached Biology News:Air pollution doesn't increase risk of preeclampsia, early delivery, study finds 2Personalized approach to smoking cessation may be reality in 3-5 years 2Personalized approach to smoking cessation may be reality in 3-5 years 3
(Date:9/2/2015)... -- Australian prostate cancer technology company Minomic International Ltd ... ,outstanding, science that uses its patented antibody. ... prostate cancer diagnostic test known as MiCheck® next year, ... the peer-reviewed Australian Museum Eureka Science Prize for ... prize is awarded for ground breaking research that has ...
(Date:9/2/2015)... Sept. 2, 2015 Veracyte, Inc. (NASDAQ: ... , president and chief executive officer, will present at ... 16, 2015 at 10:30 a.m. ET in ... live audio webcast and subsequent replay may be accessed ... be available shortly after conclusion of the presentation and ...
(Date:9/2/2015)... , September 2, 2015 BiondVax Pharmaceuticals ... the National Institute of Allergy and Infectious Diseases (NIAID), part ... Department of Health and Human Services (HHS), to launch a ... the United States in the 2015-16 timeframe. The ... candidate, Multimeric-001 (M-001), as a primer vaccine, which would be ...
(Date:9/2/2015)... Orange, California (PRWEB) , ... September 02, 2015 ... ... been a critical demand to aid high-risk surgeries. From vital sign monitoring in ... powered by Intel technology enables surgeon to make real-time clinical decisions with simultaneous ...
Breaking Biology Technology:Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Veracyte to Present at Morgan Stanley Global Healthcare Conference 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 2Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 3
... Feb. 4 With most liver cancer caused by undetected ... cases of liver cancer that are diagnosed each year could be ... gap for federal viral hepatitis education, screening, and surveillance programs, the ... the comments in conjunction with World Cancer Day 2010 , ...
... , , RICHMOND, Calif. , ... fourth quarter and full year 2009 financial results and accomplishments and provided an ... 2009 , Sangamo reported a consolidated net loss of $2.4 million , ... $2.6 million , or $0.06 per share, for the same period ...
... , , , , ... The U.S. Environmental Protection Agency,(EPA) has confirmed that ethanol made ... significantly to the reduction of greenhouse gas,(GHG) emissions. As part ... Fuel Standard (RFS2), the EPA designated,sugarcane ethanol as an advanced ...
Cached Biology Technology:NVHR: Stop Liver Cancer 'Dead in Its Tracks' By Closing Funding Gap for Viral Hepatitis Education, Screening Programs 2NVHR: Stop Liver Cancer 'Dead in Its Tracks' By Closing Funding Gap for Viral Hepatitis Education, Screening Programs 3Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 2Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 3Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 4Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 5Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 6Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 7Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 8Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 9Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 10Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 11Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 12Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 13EPA Reaffirms Sugarcane Biofuel is Advanced Renewable Fuel with 61% Less Emissions than Gasoline 2EPA Reaffirms Sugarcane Biofuel is Advanced Renewable Fuel with 61% Less Emissions than Gasoline 3EPA Reaffirms Sugarcane Biofuel is Advanced Renewable Fuel with 61% Less Emissions than Gasoline 4
Mouse polyclonal antibody raised against a partial recombinant CSRP3. NCBI Entrez Gene ID = 8048...
Mouse monoclonal antibody raised against a partial recombinant EOMES. NCBI Entrez Gene ID = EOMES...
...
... 2-D Sample Preparation for Membrane Proteins ... 25 membrane,protein extracts for 2-D gel analysis ... Protein Extraction Kit , (contains ... with a packed cell weight of 10 ...
Biology Products: