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Solexa and collaborating scientists illuminate the small RNA component of the transcriptome

Solexa, Inc. (Nasdaq: SLXA) today announced that its researchers in collaboration with the Delaware Biotechnology Institute and the University of Delaware reported the most comprehensive analysis to date of the small RNA component of the transcriptome. The research, "Elucidation of the Small RNA Component of the Transcriptome," was published in the September 2, 2005 issue of the peer-reviewed journal Science. Solexa's assay can be used to elucidate small RNAs in any plant or animal species, notably humans.

"Finding that small RNAs comprise a potent set of regulatory molecules in diverse organisms is among the most important discoveries in the past 10 years," stated John West, Solexa's chief executive officer. "This research is pioneering in its ability to characterize these important regulatory molecules on a genome-wide scale."

Solexa's technology has the advantage of producing highly accurate, reproducible and quantitative readouts of the full complement of activated genes and small RNAs, including genes expressed at low levels, without requiring advance knowledge of the genes or sequences of interest. Solexa performed this research in its Genomic Services business unit. The Company also intends to develop this small RNA assay for use with its next-generation sequencing platform, which is scheduled to be introduced to the market by the end of this year.

Using Solexa's unique high-throughput sequencing technology, the study identified over 77,000 unique small RNAs in Arabidopsis plants, 10 times more than previously known. This study, funded by the National Science Foundation, generated more than two million short DNA sequences, known as signature sequences or sequence tags, to identify and quantify both known and novel small RNA molecules. Many regions of the Arabidopsis genome previously considered to be inactive or featureless were found to be sites of considerable small RNA activity.

"The signature sequencing approach makes possib
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Source:Lippert/Heilshorn and Associates


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