Navigation Links
Soil-bound prions that cause CWD remain infectious

Researchers discovered a new bacterium in an immune-compromised patient, according to a study recently published in PLoS Pathogens. The bacterium belongs to the family Acetobacteraceae and includes bacteria common in the environment, some of which are used in industry, such as vinegar-making. "This is the first reported case of invasive human disease caused by any of the Acetobacteraceae," according to the article.

The new bacterium was identified in a patient with chronic granulomatous disease (CGD), a rare genetic disorder that impairs the immune system. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death.

The journal also published an editorial entitled, "Extending the Spectrum of Human Pathogens," which comments on the significance of the discovery.

Usually, our immune systems fight off most bacteria and fungi with everyday ease, thwarting infection. But patients with CGD cannot control attacks by certain bacteria and fungi. The disorder prevents immune cells called neutrophils from functioning properly, and recurrent --and potentially life-threatening-- infections result.

The team isolated the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote.

Despite ineffective neutrophil immune cells, the patient's immune system still tagged the bacterium as an invader. Researchers also exposed CGD mice to the bacterium, recreating the appearance of the patient's infection. Researchers were then able to retrieve the bacteria from the mice's spleens, which are disease-fighting organs. These factors all support the pathogenic nature of the bacterium.

Because the bacterium does not cause death, it may be provide useful comparison with more menacing bacteria and fungi in CGD patients. "Given its appare nt low virulence, further investigation of this organism may shed light on the mechanisms of microbial killing in CGD. Comparing the genome of this organism to other 13 available genomes of CGD pathogens may provide clues to virulence properties that they share in common," according to the article.


'"/>

Source:University of Wisconsin-Madison


Related biology news :

1. First technology to remove prions that cause vCJD from blood launched
2. Research into how prions act in the brain could hold the key to defeating diseases
3. Brittle prions are more infectious
4. Dysentery uses sword and shield to cause infection
5. Scientists detect probable genetic cause of some Parkinsons disease cases
6. BRCA1 causes ovarian cancer through indirect, biochemical route
7. Scientists decipher genome of fungus that can cause life-threatening infections
8. Researchers discover molecule that causes secondary stroke
9. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
10. NASA study finds snow melt causes large ocean plant blooms
11. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
Breaking Biology News(10 mins):
(Date:6/22/2016)... Research and Markets has announced the addition of the ... The global biomarkers market has ... The market is expected to grow at a five-year compound annual ... $50.6 billion in 2015 to $96.6 billion in 2020. ... to 2020) are discussed. As well, new products approved in 2013 ...
(Date:6/22/2016)... 2016   StockNewsNow.com , The Official MicroCap News ... Nader Pourhassan , President & CEO of CytoDyn ... clinical development and potential commercialization of humanized monoclonal antibodies ... to the company,s website (see here: www.CytoDyn.com ). ... th , 2016, at the LD Micro Invitational in ...
(Date:6/22/2016)... --  ViaCyte, Inc. , a privately-held regenerative medicine company ... for the treatment of diabetes in clinical-stage development, today ... 2016, the Global Stem Cell Event, is taking place ... Francisco.    ... Focus Session: Tools for Basic and Applied Stem Cell ...
(Date:6/22/2016)... ... June 22, 2016 , ... ... spotlight on immigrant achievements and contributions to North Texas and the nation, recently ... from the immigrant community to the civic and economic vitality of North Texas. ...
Breaking Biology Technology: