Navigation Links
Smoking damages key regulatory enzyme in the lung

Study in Journal of Nuclear Medicine uses PET, radiotracer to track enzyme in smokers, nonsmokersRESTON, Va.-- Smoking appears to reduce a key enzyme in the lungs, possibly contributing to some of smoking's deleterious health effects, according to a study published in the September issue of the Journal of Nuclear Medicine. The study, which used a radiotracer to track the enzyme, also shows that smokers had a lower concentration of the tracer in the bloodstream than nonsmokers did, leading to speculation that smokers and nonsmokers may respond differently to a variety of substances administered by inhalation or intravenously, including therapeutic, anesthetic and addictive drugs.

"The effects of smoking on human health are enormous; yet, little is known about the pharmacologic effects of smoking on the human body apart from the effects of nicotine," noted Joanna S. Fowler, Ph.D., program director of the Brookhaven Center for Translational Neuroimaging in Upton, N.Y. Researchers from Brookhaven National Laboratory, the National Institute on Drug Abuse and the State University of New York at Stony Brook used positron emission tomography (PET) scanning and a tracer chemical that binds to a specific form of the enzyme monoamine oxidase (MAO A) to track MAO A levels in both smokers and nonsmokers. With whole-body PET imaging, researchers could measure the concentration and movement of the radiotracer and MAO A, a subtype of the enzyme crucial to mood regulation and one that breaks down chemical compounds that elevate blood pressure, said the Society of Nuclear Medicine member.

In the study, "Comparison of Monoamine Oxidase A in Peripheral Organs in Nonsmokers and Smokers," researchers traced the MAO A subtype in nine smokers and nine nonsmokers, discovering that MAO A was fairly well "intact" in all of the peripheral organs except in smokers' lungs, said Fowler. Smokers had MAO A levels that were 50 percent lower than in nonsmokers, she said, noting that a
'"/>

Source:Society of Nuclear Medicine


Page: 1 2 3

Related biology news :

1. Smoking changes brain chemistry
2. Smoking ban dramatically reduces air pollution in Irish pubs
3. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
4. White blood cell waste disposal system plays critical regulatory role
5. Researchers rein in regulatory RNAs
6. OneWorld Health drug receives Orphan designation from U.S. and European regulatory agencies
7. New technique helps identify multiple DNA regulatory sites
8. Master regulatory gene found that guides fate of blood-producing stem cells
9. Key brain regulatory gene shows evolution in humans
10. New methods offer insight into regulatory DNA
11. Novel regulatory mechanism identified for key tumor suppressor p53
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Smoking damages key regulatory enzyme the lung

(Date:6/24/2015)... June 24, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced that Sharp has selected its ... authentication for its latest flagship smartphone device, the ... 200 million shipments of its fingerprint ID sensor ... strength, scalability and leadership in the biometrics market ...
(Date:6/23/2015)...   MedNet Solutions , an innovative SaaS-based ... of clinical research, is pleased to announce that ... company,s intuitive, flexible and affordable cloud-based eClinical technology ... Award by the American Business Awards (SM) ... The American Business Awards are considered the nation,s ...
(Date:6/23/2015)... , June 23, 2015  Crossmatch™, ... and authentication solutions, today announced enhanced functionality of ... authentication solution.  The enhancements build on the ... the DigitalPersona Altus platform and provide expanded ... In today,s environment of increasing ...
Breaking Biology News(10 mins):Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... a major food source for much of the world, rice is ... safe from disease has become, in part, the task of a ... Kansas State University. The researchers are looking at two bacterial ... which is caused by a bacterium called Xanthomonas oryzae pathovar ...
... Engineers at Oregon State University have made a major ... run a cooling system a technology that can improve ... will appear in automobiles, homes and industry. This heat-actuated ... the U.S. Army, could ultimately be applied to automobiles, factories ...
... herders are facing the challenges of adapting to climate ... for herds to find food and navigate. To help ... them with satellite-based snow maps. "Snow is of ... whether reindeer are able to access the pastures that ...
Cached Biology News:Researchers examine bacterial rice diseases, search for genetic solutions 2Breakthrough made in energy efficiency, use of waste heat 2Breakthrough made in energy efficiency, use of waste heat 3Satellite snow maps help reindeer herders adapt to a changing Arctic 2
(Date:6/30/2015)... , June 30, 2015  The Dr. Samadi Prostate ... is now offering a full suite of new genetic testing ... a biopsy, for diagnosing prostate cancer. ... of genetic tests for assessing the risk and optimizing the ... "We,re very excited to now offer these revolutionary genetic ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... launched “Cannavoices,” an unprecedented digital video and broadcast initiative. Produced by filmmakers, the ... dynamic collection of legal medical cannabis stories ever assembled. , Cannavoices profiles ...
(Date:6/29/2015)... , ... June 29, 2015 , ... ... B2. Under the terms of the agreement, MediVet will acquire the rights to ... (UCMSCs). MB-007 is currently in pre-clinical development as a potential next-generation treatment for ...
(Date:6/29/2015)... 29, 2015  AACC, a global scientific and ... laboratory medicine, is pleased to announce that the ... , has increased to 7.9 in the 2014 ... Clinical Chemistry in the top 3% ... influence of the research it publishes on laboratory ...
Breaking Biology Technology:New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5Cannavoices Launches a Legal Medical Cannabis Documentary Initiative 2Cannavoices Launches a Legal Medical Cannabis Documentary Initiative 3MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3
... , , BOTHELL, Wash., Aug. 7 ... reported financial results for the three and six months ended June ... Morra, SCOLR Pharma,s President and CEO, said, "We continue to advance ... release ibuprofen. These potential partners have been committing resources to due ...
... EXTON, Pa., Aug. 7 Kensey Nash Corporation ... the distribution rights, along with the trademark, inventory and ... product line. Under the terms of the agreement, the ... existing OsseoFit distribution agreement. Pursuant to the agreement, following ...
... , CORAL GABLES, Fla., Aug. 7 Catalyst Pharmaceutical Partners, Inc. ... and six months ended June 30, 2009. , , ... For the quarter ended June 30, 2009, the Company reported a net loss ... loss of $2,377,440, or $0.19 per basic and diluted share for the same ...
Cached Biology Technology:SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 2SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 3SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 4SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 5SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 6SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 7SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 8Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 2Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 3Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 2Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 4Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 5Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 6Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 7
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Edited by I.H. Pawlowitzki, J.H. Edwards and E.A. Thompson (1997) • This volume covers: Linkage in dominant recessive and oligogenic disease, Model free (non-parametric) methods, Tools for gene ...
Biology Products: