Navigation Links
'Smart' nanoprobes light up disease

Researchers from Rice University's Center for Biological and Environmental Nanotechnology (CBEN) have developed a "smart" beacon hundreds of times smaller than a human cell that is programmed to light up only when activated by specific proteases. Altered expression of particular proteases is a common hallmark of cancer, atherosclerosis, and many other diseases.

In the September issue of the journal Biochemical and Biophysical Research Communications, lead authors Jennifer West, the Isabel C. Cameron Professor of Bioengineering and director of CBEN's biological research program, and Rebekah Drezek, the Stanley C. Moore Assistant Professor of Bioengineering and assistant professor of electrical and computer engineering, describe development of a new nanoprobe for visualization of proteolytic activity in vivo.

"The idea is to develop a 'smart' nanostructure that is dark in its original state but lights up very brightly in the presence of enzymatic activity associated with a particular disease process," said West. "Other groups have used targeted nanostructures including quantum dots for molecular imaging, but they have never been able to adequately solve the problem of clearly distinguishing between the 'cancer is here' signal and the background light which arises from nanostructures not specifically bound to their molecular targets."

Rice's technology solves this longstanding problem by using emissive nanoparticles called quantum dots that give off light in the near-infrared (NIR), a rare portion of the spectrum that has no background component in biomedical imaging. Near-infrared light also passes harmlessly through skin, muscle and cartilage, so the new probes could alert doctors to tumors and other diseases sites deep in the body without the need for a biopsy or invasive surgery.

The probe's design makes use of a technique called "quenching" that involves tethering a gold nanoparticle to the quantum dot to inhibit luminescence. The te
'"/>

Source:Rice University


Page: 1 2

Related biology news :

1. Smart genetic therapy helps the body to heal itself
2. UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice
3. Researchers discover way to make cells in the eye sensitive to light
4. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
5. Bacteria collection sheds light on urinary tract infections
6. Sea skate experiment sheds light on human cell transport
7. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
8. McGill researchers shed light on formation of carcinogen in food
9. Scientists discover how plants disarm the toxic effects of excessive sunlight
10. Medical molecules designed to respond to visible light that can penetrate tissue
11. Genetic defects give the immune system the green light to attack the pancreas
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Smart nanoprobes light disease

(Date:12/11/2014)... 2014  That blood pressure plays a role in human ... the medical term for high blood pressure – was first ... inflatable cuff that,s used in measuring blood pressure was invented ... new about hypertension, its triggers and its effects. In fact, ... and the best ways to treat it. For ...
(Date:12/10/2014)... YORK , Dec. 8, 2014 You,ve been ... banking account but can,t remember your password, site key or ... Who was your first grade teacher? Today, ... the app that will finally put an end ... – 1U TM . 1U leverages a user,s ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... for its School of Medicine. Funding for this $50 ... campaign that will be publicly launched next summer. ... in the former 60 series R.J. Reynolds Tobacco Company ... Construction will begin immediately with plans to be ready ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... plant geneticists and crop scientists has pioneered an economical ... boost levels of provitamin A, the precursors that are ... help to enhance the nutritional status of millions of ... is described this week in the journal Science. ...
... Genetic Alliance, an organization devoted to accelerating the translation ... healthcare, has named Genetic Testing as its official journal. Genetic ... Inc. ... Genetic Testing, says Sharon Terry, President and CEO of Genetic ...
... Australias extinct marsupial lion (Thylacoleo carnifex) would have made ... the two big hyper-carnivores ever squared off in a ... New research published in the Journal of Zoology ... type teeth to scissor through hide and flesh to ...
Cached Biology News:Team finds an economical way to boost the vitamin A content of maize 2Team finds an economical way to boost the vitamin A content of maize 3Genetic Alliance names Genetic Testing as its official journal 2Marsupial lion tops African lion in fight to death 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Once more, ... provide a larger packaged waste water treatment plant to ... Abdullah Economic City (KAEC). Two years ago Bioshaft successfully ... Gate Development, serving two residential towers with an occupancy ... over a quarter million gallons per day and was ...
(Date:12/17/2014)... 2014 Xeno Diagnostics has again ... most recent COLA inspection. Xeno has met all ... healthcare accreditation organization. Accreditation is earned only by ... day-to-day operations, demonstrate continued accuracy in the performance ... laboratory survey. , While the Laboratory ...
(Date:12/17/2014)... Diego, CA (PRWEB) December 17, 2014 ... and activation agency and member of the Huntsworth Health ... Gonzales to its executive team. In her role, Gonzales ... , “We are incredibly honored to welcome a ... Agency Chief and CEO, Gaëtan Fraikin. “She is a ...
(Date:12/17/2014)... 17, 2014  United Therapeutics Corporation (NASDAQ: ... well as changes to Martine Rothblatt , Ph.D,s ... United Therapeutics announced the promotion of ... Officer and David Zaccardelli , Pharm.D. to Executive ... these promotions, Dr. Rothblatt,s title will change from Chairman ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... everything from explosives to tainted milk, materials for use ... by a University of Houston (UH) chemist and his ... "There are many dangerous substances, pollutants and ... Advincula, a highly cited materials scientist at UH. "Our ...
... February 7, 2011 -- A low cost, nanometer-sized drug ... burns, has been developed by a group of scientists from ... in the U.S. and Japan. Diabetes is a ... the world,s population. Poor blood circulation arising from diabetes often ...
... Feb. 16, 2011 / PRNewswire/ -- Sigma-Aldrich® ... following executive leadership appointments intended to more closely ... Frank Wicks, President Research, will assume ... including those in Research Essentials, Research Specialties and ...
Cached Biology Technology:Sensors to detect explosives, monitor food being developed at UH 2Sensors to detect explosives, monitor food being developed at UH 3Sigma-Aldrich Announces Organizational Changes 2Sigma-Aldrich Announces Organizational Changes 3
... multi-purpose, high gel-strength agarose suitable for a ... conventional constant field to Pulsed Field Gel ... strength and exclusion limits, Multi ABgarose can ... running times. This in turn means reduced ...
Mouse monoclonal [1.F.1] to Yersinia pestis F1 antigen ( Abpromise for all tested applications). Antigen: Purified F1 antigen of Y. pestis vaccine strain EB....
Rabbit polyclonal to L Kynurenine ( Abpromise for all tested applications). Antigen: Synthetic peptide L Kynurenine conjugated to a protein carrier. Entrez Gene ID: 8942 Swiss Protein ID...
Rabbit polyclonal to P5 ( Abpromise for all tested applications). entrezGeneID: 10954 SwissProtID: Q14554...
Biology Products: