Navigation Links
'Smart drug' targets deadly brain cancer

A study led by Mayo Clinic researchers and conducted by the North Central Cancer Treatment Group (NCCTG) reports that a new "smart" drug treatment for an incurable form of recurrent brain cancer slowed tumor growth in more than one-third of the 65 adult patients who tried it. The same research team also developed a screening technique to help predict which patients will respond best to this treatment.

Mayo researchers will present these findings at the 2005 American Society of Clinical Oncology (ASCO) Annual Meeting in Orlando, Fla. The NCCTG study addressed the most common kind of tumor arising from brain tissue of adults, glioblastoma mutiforme. Current treatment outcomes for this type of cancer are extremely poor: median patient survival is 12 to 16 months, and recurrent disease has a dismal prognosis. The World Health Organization categorizes fast-growing glioblastoma multiforme as a grade IV cancer.

Significance of the Mayo Clinic/NCCTG Research

This discouraging prognosis may change as a result of the rational foundation for new therapies the NCCTG research provides. Study data showed that in 36 percent of patients suffering from recurrent glioblastoma multiforme, the new "smart" drug behaved as hypothesized: It found its target -- tumor cells -- and actively worked against them to slow tumor growth.

According to the study's lead investigator, Mayo Clinic medical oncologist Evanthia Galanis, M.D., "Treatment was well tolerated, and imaging responses were observed in a significant portion (36 percent) of patients with recurrent glioblastoma multiforme participating in this study -- which is a high response rate for this very resistant disease. These early results suggest that we are on to a promising new treatment strategy that could potentially help us improve treatment for patients with recurrent glioblastoma."

Achieving the 36 percent regression rate was an encouraging result -- but researchers didn't stop there. They t ook the work a step further by analyzing specific tumor properties of the patients enrolled in the study. What they found is also encouraging. Patients most likely to respond well to the drug shared a common feature -- activation of a specific tumor protein, p70s6 kinase, which is closely associated with the drug target molecule.

Knowing that this protein is a key player in the chain of events that determines drug activity could be useful in screening patients to help determine the best candidates for the drug. Says Dr. Galanis, "This could allow us to customize drug administration to the patients most likely to benefit from it, and in that way, improve care."

A Smart Drug

In their study, NCCTG researchers used an investigational drug that is not currently available for wide use. Known as CCI-779, or temsirolimus, it is a "smart" drug in the sense that it has been designed to target specific changes in the glioblastoma multiforme tumor cells that previous studies have identified as key factors in the tumor's aggressive behavior.

About Glioblastoma Multiforme

In adults, glioblastoma multiforme is the most common form of brain tumor. Because it originates in the brain, physicians refer to it as a primary tumor. This is in contrast to a tumor that develops in the brain from cancer cells that have spread from tumors elsewhere in the body. Glioblastoma multiforme accounts for more than 50 percent of the estimated 18,000 primary malignant brain tumors diagnosed each year in the United States. When first diagnosed, glioblastoma multiforme is usually treated with surgery, radiation therapy and chemotherapy -- and median survival is 12 to 16 months. For patients in whom the disease recurs, the prognosis is indeed dismal: there are no good treatment options.

The Next Step

Mayo Clinic researchers are continuing to investigate the implications of their findings. NCCTG studies now under way will test the combination of CCI- 779 with radiation therapy in patients who have newly diagnosed glioblastoma multiforme. They will also test CCI-779 in combination with other targeted therapies in patients with recurrent cases of glioblastoma multiforme.

Collaboration and Support

In addition to Dr. Galanis, Mayo Clinic research team members included Jan Buckner, M.D.; Matthew Maurer, M.S.; Brad Erickson, M.D., Ph.D.; Bernd Scheithauer, M.D.; Robert Jenkins, M.D., Ph.D.; and Karla Ballman, Ph.D. External collaborators included researchers from Johns Hopkins University and the University of Texas, San Antonio.


'"/>

Source:Mayor Clinic


Related biology news :

1. Smart nanoprobes light up disease
2. Smart genetic therapy helps the body to heal itself
3. Anti-inflammatory drugs potentially deadly side effect found to be rare
4. Chemical maps hint at drugs effects on schizophrenia
5. A bacterial genome reveals new targets to combat infectious disease
6. Study reveals candidate targets for anti-retroviral therapeutics
7. NHGRI targets 12 more organisms for genome sequencing
8. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
9. Novel targets found for the development of drugs to complement, or replace, statins
10. Vaccine targets tumors where they live
11. Study findings offer potential new targets for antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/16/2017)... , Feb. 16, 2017  Genos, a ... announced that it has received Laboratory Accreditation from ... Accreditation is presented to laboratories that meet stringent ... demonstrate scientifically rigorous processes. "Genos is ... in laboratory practices. We,re honored to be receiving ...
(Date:2/10/2017)... Research and Markets has announced ... - Scientific and Commercial Aspects" to their offering. ... Biomarkers ... with therapy for selection of treatment as well for monitoring ... of disease in modern medicine. Biochip/microarray technologies and next generation ...
(Date:2/8/2017)... YORK , Feb. 7, 2017 Report Highlights ... The ... should reach $11.4 billion by 2021, growing at a compound ... Includes - An overview of the global markets for synthetic ... 2015, estimates for 2016, and projections of compound annual growth ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... SAN DIEGO , Feb. 24, 2017  Aethlon ... the following note authored by its Chairman and CEO, ... address at the Munich Security Conference last Saturday, ... engineered virus could kill more people than nuclear weapons. ... by U.S. and U.K. intelligence agencies, that scientific terrorists ...
(Date:2/24/2017)... Staten Island, NY (PRWEB) , ... February 24, 2017 , ... ... exponential rate. Founded in late 2014, FireflySci had the goal of bringing their ... 2017, that goal continues to shape the path that FireflySci is going on as ...
(Date:2/23/2017)... NEW YORK , Feb. 23, 2017 /PRNewswire/ ... leading digital health company, and Digital Noema ... and remote patient monitoring, announce they are partnering ... DN Telehealth maximizes collaboration compatibility for ... consultations beyond a physical clinical setting to include ...
(Date:2/23/2017)... 23, 2017  MIODx announced today that it ... immunotherapy technologies from the University of California, San ... to monitor a patient for response to immune ... The second license extends the technology with a ... to have an immune-related adverse event (IRAE) from ...
Breaking Biology Technology: