Navigation Links
Smallpox outbreak: How long would it take for vaccines to protect people? Would it work?

In the event of a smallpox outbreak in the United States, how long would it take for a vaccinSLU scientist leads national studye to start protecting Americans by stimulating an immune response?

A new national study led by Saint Louis University School of Medicine will attempt to answer this question.

General routine vaccinations for smallpox were stopped in the United States in 1971, and the world was declared free of smallpox in 1980. But because of the recent concern about biowarfare and bioterrorism throughout the world, the U.S. government is making efforts to improve its ability to protect its citizens in the event of a bioterrorist attack involving the smallpox virus (Variola major virus).

This study at Saint Louis University will look at the ability of an investigational vaccine made by Bavarian Nordic to stimulate the immune system against smallpox.

"Vaccines prevent disease by giving the body a jump-start at recognizing the infecting virus or bacteria," said Sharon Frey, M.D., the principal investigator for the study at Saint Louis University. "After successful vaccination, the body experiences a quicker fighting response to the infection, which lessens or completely avoids the symptoms of illness."

Unlike some other diseases, getting vaccinated following exposure to smallpox could provide protective effects. For example, for the flu vaccine to work, people need to get vaccinated before being exposed to influenza. The currently licensed smallpox vaccine, however, provides benefits post-exposure, and may be useful in further preventing the spread of the disease.

"If there were a release of the smallpox virus, we would vaccinate people immediately after the release," Frey said. "We'd move in and vaccinate people to prevent the spread."

Frey said this research compares the ability of a new investigational smallpox vaccine called IMVAMUNE® to produce a strong immune response against smallpox d isease with another vaccine called Dryvax®, the currently licensed vaccine. The new vaccine will be given either alone or in combination with Dryvax.

"Another purpose of the study is to see how quickly people can be protected against smallpox after a release of smallpox into the environment," Frey said.

Dryvax® vaccine is the original Food and Drug Administration (FDA) licensed vaccine that was used to protect humans against smallpox disease. In this study, the Dryvax® vaccine is being used as a research vaccine because its use in this study is different than the FDA approved current recommended use of this licensed vaccine.

The Dryvax® vaccine is made from a live virus called vaccinia. The only people who presently receive this vaccine are people who work with viruses associated the risk of similar "pox" diseases; these are called by names like vaccinia, orthopox and monkeypox virus. (This group includes some government employees, some emergency workers military personnel and researchers).


'"/>

Source:Saint Louis University


Related biology news :

1. $5.1 billion would save 6 million children
2. President Bushs cut to AIDS prevention in Africa would be devastating
3. Ethical guidelines suggested for research that would put human stem cells in primates
4. Proposal would allow wild animals to roam North America
5. Cookbook recipes would cure disease with nontoxic DNA delivery systems
6. New discovery: If it werent for this enzyme, decomposing pesticide would take millennia
7. Some people would give life or limb not to be fat
8. Designer babies - what would you do for a healthy baby?
9. Live vaccines more effective against horse herpes virus
10. Designing vaccines by computer
11. Improving the potential of cancer vaccines
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Any expert in stem ... compromised these disciplines for more than half a century. Despite their essential roles ... It is widely known that molecular tags developed for this purpose also tag other, ...
(Date:8/15/2017)... ... August 15, 2017 , ... Coffea arabica accounts ... and abiotic factors. During this educational webinar, participants will learn about the importance ... gain a better understanding of how genomics is important for coffee breeding improvement. ...
(Date:8/14/2017)... Oregon (PRWEB) , ... August 14, 2017 , ... ... that provide essential device-to-computer interconnect using USB or PCI Express, announced the release ... , SYZYGY is intended to satisfy the need for a compact, low cost, ...
(Date:8/11/2017)... Antonio, Texas (PRWEB) , ... August 11, 2017 , ... ... a rebranding campaign this month that will incorporate important key elements including a new ... thank the community that has supported them, Bill Miller has partnered with the South ...
Breaking Biology Technology: